Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves
Foot‐and‐mouth disease (FMD) vaccines are routinely used as effective control tools in large regions worldwide and to limit outbreaks during epidemics. Vaccine‐induced protection in cattle has been largely correlated with the FMD virus (FMDV)‐specific antibodies. Genetic control of cattle immune ada...
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
2018
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| Online Access: | https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.12130 http://hdl.handle.net/20.500.12123/2510 https://doi.org/10.1111/tbed.12130 |
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| author | Di Giacomo, Sebastián Brito, Barbara Patricia Perez, A.M. Bucafusco, Danilo Pega, Juan Franco Rodríguez, L. Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author_browse | Borca, Manuel Victor Brito, Barbara Patricia Bucafusco, Danilo Di Giacomo, Sebastián Pega, Juan Franco Perez Filgueira, Daniel Mariano Perez, A.M. Rodríguez, L. |
| author_facet | Di Giacomo, Sebastián Brito, Barbara Patricia Perez, A.M. Bucafusco, Danilo Pega, Juan Franco Rodríguez, L. Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author_sort | Di Giacomo, Sebastián |
| collection | INTA Digital |
| description | Foot‐and‐mouth disease (FMD) vaccines are routinely used as effective control tools in large regions worldwide and to limit outbreaks during epidemics. Vaccine‐induced protection in cattle has been largely correlated with the FMD virus (FMDV)‐specific antibodies. Genetic control of cattle immune adaptive responses has been demonstrated only for peptide antigens derived from FMDV structural proteins. Here, we quantify the heterogeneity in the antibody response of cattle primo‐vaccinated against FMD and study its association with the genetic background in Holstein and Jersey sires. A total of 377 FMDV‐seronegative calves (122 and 255 calves from 16 and 15 Holstein and Jersey sires, respectively) were included in the study. Samples were taken the day prior to primo‐vaccination and 45 days post‐vaccination (dpv). Animals received commercial tetravalent FMD single emulsion oil vaccines formulated with inactivated FMDV. Total FMDV‐specific antibody responses were studied against three viral strains included in the vaccine, and antibody titres were determined by liquid‐phase blocking ELISA. Three linear hierarchical mixed regression models, one for each strain, were formulated to assess the heterogeneity in the immune responses to vaccination. The dependent variables were the antibody titres induced against each FMDV strain at 45 dpv, whereas sire's ‘breed’ was included as a fixed effect, ‘sire’ was included as a random effect, and ‘farm’ was considered as a hierarchical factor to account for lack of independence of within herd measurements. A significant association was found between anti‐FMDV antibody responses and sire's breed, with lower immune responses found in the Jersey sires’ offspring compared with those from Holstein sires. No significant intrabreed variation was detected. In addition, farm management practices were similar in this study, and results of the serological assays were shown to be repeatable. It therefore seems plausible that differences in the immune response may be expected in the event of a mass vaccination campaigns. |
| format | Artículo |
| id | INTA2510 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA25102019-06-05T18:22:43Z Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves Di Giacomo, Sebastián Brito, Barbara Patricia Perez, A.M. Bucafusco, Danilo Pega, Juan Franco Rodríguez, L. Borca, Manuel Victor Perez Filgueira, Daniel Mariano Ternero Enfermedades de los Animales Fiebre Aftosa Vacunación Anticuerpos Calves Animal Diseases Foot and Mouth Disease Vaccination Antibodies Foot‐and‐mouth disease (FMD) vaccines are routinely used as effective control tools in large regions worldwide and to limit outbreaks during epidemics. Vaccine‐induced protection in cattle has been largely correlated with the FMD virus (FMDV)‐specific antibodies. Genetic control of cattle immune adaptive responses has been demonstrated only for peptide antigens derived from FMDV structural proteins. Here, we quantify the heterogeneity in the antibody response of cattle primo‐vaccinated against FMD and study its association with the genetic background in Holstein and Jersey sires. A total of 377 FMDV‐seronegative calves (122 and 255 calves from 16 and 15 Holstein and Jersey sires, respectively) were included in the study. Samples were taken the day prior to primo‐vaccination and 45 days post‐vaccination (dpv). Animals received commercial tetravalent FMD single emulsion oil vaccines formulated with inactivated FMDV. Total FMDV‐specific antibody responses were studied against three viral strains included in the vaccine, and antibody titres were determined by liquid‐phase blocking ELISA. Three linear hierarchical mixed regression models, one for each strain, were formulated to assess the heterogeneity in the immune responses to vaccination. The dependent variables were the antibody titres induced against each FMDV strain at 45 dpv, whereas sire's ‘breed’ was included as a fixed effect, ‘sire’ was included as a random effect, and ‘farm’ was considered as a hierarchical factor to account for lack of independence of within herd measurements. A significant association was found between anti‐FMDV antibody responses and sire's breed, with lower immune responses found in the Jersey sires’ offspring compared with those from Holstein sires. No significant intrabreed variation was detected. In addition, farm management practices were similar in this study, and results of the serological assays were shown to be repeatable. It therefore seems plausible that differences in the immune response may be expected in the event of a mass vaccination campaigns. Instituto de Virología Fil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Brito, Barbara Patricia. University of California Davis. School of Veterinary Medicine. Center for Animal Diseases Modeling and Surveillance. Department of Medicine and Epidemiology; Estados Unidos Fil: Perez, A.M. University of California Davis. School of Veterinary Medicine. Center for Animal Diseases Modeling and Surveillance. Department of Medicine and Epidemiology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pega, Juan Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rodríguez, L. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados Unidos Fil: Borca, Manuel Victor. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados Unidos Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2018-05-29T15:52:23Z 2018-05-29T15:52:23Z 2015-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.12130 http://hdl.handle.net/20.500.12123/2510 1865-1674 1865-1682 https://doi.org/10.1111/tbed.12130 eng info:eu-repo/semantics/restrictedAccess application/pdf Transboundary and emerging diseases 62 (3) : 280-287. (June 2015) |
| spellingShingle | Ternero Enfermedades de los Animales Fiebre Aftosa Vacunación Anticuerpos Calves Animal Diseases Foot and Mouth Disease Vaccination Antibodies Di Giacomo, Sebastián Brito, Barbara Patricia Perez, A.M. Bucafusco, Danilo Pega, Juan Franco Rodríguez, L. Borca, Manuel Victor Perez Filgueira, Daniel Mariano Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves |
| title | Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves |
| title_full | Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves |
| title_fullStr | Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves |
| title_full_unstemmed | Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves |
| title_short | Heterogeneity in the antibody response to foot‐and‐mouth disease primo‐vaccinated calves |
| title_sort | heterogeneity in the antibody response to foot and mouth disease primo vaccinated calves |
| topic | Ternero Enfermedades de los Animales Fiebre Aftosa Vacunación Anticuerpos Calves Animal Diseases Foot and Mouth Disease Vaccination Antibodies |
| url | https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.12130 http://hdl.handle.net/20.500.12123/2510 https://doi.org/10.1111/tbed.12130 |
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