Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis
Dietary uptake is estimated using residue data from food commodities and predicting the effect of food processing, such as peeling. The aim of this study was to explore the value of the analysis of duplicate portions supplemented by the analysis of urinary metabolites. Forty-three participants, cons...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2026
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/24996 https://www.sciencedirect.com/science/article/pii/S0273230025002041?via%3Dihub https://doi.org/10.1016/j.yrtph.2025.105972 |
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| author | Wieland, Nina Figueiredo, Daniel Mol, Hans González, Neus Abrantes, Nelson Aparicio, Virginia Carolina Campos, Isabel Contreras, Josefina Francisco, Alcon Glavan, Matjaž Blagus, Tanja Dolžan, Vita Harkes, Paula Nørgaard, Trine Schlünssen, Vivi Pasković, Igor Polić Pasković, Marija Graumans, Martien Ragas, Ad Russel, Frans Scheepers, Paul |
| author_browse | Abrantes, Nelson Aparicio, Virginia Carolina Blagus, Tanja Campos, Isabel Contreras, Josefina Dolžan, Vita Figueiredo, Daniel Francisco, Alcon Glavan, Matjaž González, Neus Graumans, Martien Harkes, Paula Mol, Hans Nørgaard, Trine Pasković, Igor Polić Pasković, Marija Ragas, Ad Russel, Frans Scheepers, Paul Schlünssen, Vivi Wieland, Nina |
| author_facet | Wieland, Nina Figueiredo, Daniel Mol, Hans González, Neus Abrantes, Nelson Aparicio, Virginia Carolina Campos, Isabel Contreras, Josefina Francisco, Alcon Glavan, Matjaž Blagus, Tanja Dolžan, Vita Harkes, Paula Nørgaard, Trine Schlünssen, Vivi Pasković, Igor Polić Pasković, Marija Graumans, Martien Ragas, Ad Russel, Frans Scheepers, Paul |
| author_sort | Wieland, Nina |
| collection | INTA Digital |
| description | Dietary uptake is estimated using residue data from food commodities and predicting the effect of food processing, such as peeling. The aim of this study was to explore the value of the analysis of duplicate portions supplemented by the analysis of urinary metabolites. Forty-three participants, consuming organic and nonorganic diets collected a duplicate portion of food and beverages for 24 h. Urine was collected up to 36 h to account for metabolism and prolonged excretion of metabolites. Pesticide residues were analysed in food portions and urine samples using LC-MS/MS and GC-MS/MS. Multiple pesticide residues were detected per food
portion. Out of 183 pesticides, 86 were detected in the diet. Glyphosate and AMPA were detected in 42 % and 30 % of all urine samples, respectively, while detection in the diet was low. A positive relationship between dietary intake and urinary excretion was found for 2,4-D and MCPA. No diet-urine relationship was observed for glyphosate and AMPA, indicating contribution from external routes of exposure. Hazard index (HI) indicated no exposure above the acceptable daily intake (ADI) for all participants. This study demonstrates how DPA combined with urine analysis gives insight into contribution of diet to total pesticide exposure compared to standard
monitoring. |
| format | Artículo |
| id | INTA24996 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA249962026-01-16T14:56:53Z Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis Wieland, Nina Figueiredo, Daniel Mol, Hans González, Neus Abrantes, Nelson Aparicio, Virginia Carolina Campos, Isabel Contreras, Josefina Francisco, Alcon Glavan, Matjaž Blagus, Tanja Dolžan, Vita Harkes, Paula Nørgaard, Trine Schlünssen, Vivi Pasković, Igor Polić Pasković, Marija Graumans, Martien Ragas, Ad Russel, Frans Scheepers, Paul Plaguicidas Dieta Orinación Ración Diaria Aceptable Pesticides Diet Urination Acceptable Daily Intake Dietary Pesticide Urinary Excretion Dietary Exposure Duplicate Portion Analysis Dietary uptake is estimated using residue data from food commodities and predicting the effect of food processing, such as peeling. The aim of this study was to explore the value of the analysis of duplicate portions supplemented by the analysis of urinary metabolites. Forty-three participants, consuming organic and nonorganic diets collected a duplicate portion of food and beverages for 24 h. Urine was collected up to 36 h to account for metabolism and prolonged excretion of metabolites. Pesticide residues were analysed in food portions and urine samples using LC-MS/MS and GC-MS/MS. Multiple pesticide residues were detected per food portion. Out of 183 pesticides, 86 were detected in the diet. Glyphosate and AMPA were detected in 42 % and 30 % of all urine samples, respectively, while detection in the diet was low. A positive relationship between dietary intake and urinary excretion was found for 2,4-D and MCPA. No diet-urine relationship was observed for glyphosate and AMPA, indicating contribution from external routes of exposure. Hazard index (HI) indicated no exposure above the acceptable daily intake (ADI) for all participants. This study demonstrates how DPA combined with urine analysis gives insight into contribution of diet to total pesticide exposure compared to standard monitoring. EEA Balcarce Fil: Wieland, Nina. Radboud University. Radboud Institute for Biological and Environmental Sciences (RIBES). Department of Environmental Science; Países Bajos Fil: Figueiredo, Daniel. Utrecht University. Institute for Risk Assessment Sciences (IRAS); Países Bajos Fil: Mol, Hans. Wageningen University & Research. Wageningen Food Safety Research (WFSR); Países Bajos Fil: González, Neus. Universitat Rovira i Virgili. Institut d’Investigació Sanitària Pere Virgili (IISPV). Laboratory of Toxicology and Environmental Health; España Fil: Abrantes, Nelson. University of Aveiro. Centre for Environmental and Marine Studies (CESAM). Department of Biology; Portugal Fil: Aparicio, Virginia Carolina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Campos, Isabel. University of Aveiro. Centre for Environmental and Marine Studies (CESAM). Department of Biology; Portugal Fil: Contreras, Josefina. Universidad Politécnica de Cartagena. Agricultural Engineering School; España Fil: Francisco, Alcon. Universidad Politécnica de Cartagena. Agricultural Engineering School; España Fil: Glavan, Matjaž. University of Ljubljana. Biotechnical Faculty. Agronomy Department; Eslovenia Fil: Blagus, Tanja. University of Ljubljana. Faculty of Medicine. Institute of Biochemistry and Molecular Genetics. Pharmacogenetics Laboratory; Eslovenia Fil. Dolžan, Vita. University of Ljubljana. Faculty of Medicine. Institute of Biochemistry and Molecular Genetics. Pharmacogenetics Laboratory; Eslovenia Fil: Harkes, Paula. Wageningen University & Research (WUR). Soil Physics and Land Management Group; Países Bajos Fil: Nørgaard, Trine. Aarhus University. Danish Ramazzini Centre. Department of Public Health; Dinamarca Fil: Schlünssen, Vivi. Aarhus University. Danish Ramazzini Centre. Department of Public Health; Dinamarca Fil: Pasković, Igor. Institute of Agriculture and Tourism. Department of Agriculture and Nutrition; Croacia Fil: Polić Pasković, Marija. Institute of Agriculture and Tourism. Department of Agriculture and Nutrition; Croacia Fil: Graumans, Martien. Radboud University. Radboud Institute for Biological and Environmental Sciences (RIBES). Department of Environmental Science; Países Bajos Fil: Ragas, Ad. Radboud University. Radboud Institute for Biological and Environmental Sciences (RIBES). Department of Environmental Science; Países Bajos Fil: Russel, Frans. Radboud University. Division of Pharmacology and Toxicology. Department of Pharmacy; Países Bajos Fil: Scheepers, Paul. Radboud University. Radboud Institute for Biological and Environmental Sciences (RIBES). Department of Environmental Science; Países Bajos 2026-01-16T14:52:34Z 2026-01-16T14:52:34Z 2026-01 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/24996 https://www.sciencedirect.com/science/article/pii/S0273230025002041?via%3Dihub 0273-2300 (impreso) 1096-0295 (online) https://doi.org/10.1016/j.yrtph.2025.105972 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Regulatory Toxicology and Pharmacology 164 : 105972. (January 2026) |
| spellingShingle | Plaguicidas Dieta Orinación Ración Diaria Aceptable Pesticides Diet Urination Acceptable Daily Intake Dietary Pesticide Urinary Excretion Dietary Exposure Duplicate Portion Analysis Wieland, Nina Figueiredo, Daniel Mol, Hans González, Neus Abrantes, Nelson Aparicio, Virginia Carolina Campos, Isabel Contreras, Josefina Francisco, Alcon Glavan, Matjaž Blagus, Tanja Dolžan, Vita Harkes, Paula Nørgaard, Trine Schlünssen, Vivi Pasković, Igor Polić Pasković, Marija Graumans, Martien Ragas, Ad Russel, Frans Scheepers, Paul Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis |
| title | Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis |
| title_full | Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis |
| title_fullStr | Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis |
| title_full_unstemmed | Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis |
| title_short | Relationship between dietary pesticide intake and urinary excretion: a pilot study using duplicate portion analysis |
| title_sort | relationship between dietary pesticide intake and urinary excretion a pilot study using duplicate portion analysis |
| topic | Plaguicidas Dieta Orinación Ración Diaria Aceptable Pesticides Diet Urination Acceptable Daily Intake Dietary Pesticide Urinary Excretion Dietary Exposure Duplicate Portion Analysis |
| url | http://hdl.handle.net/20.500.12123/24996 https://www.sciencedirect.com/science/article/pii/S0273230025002041?via%3Dihub https://doi.org/10.1016/j.yrtph.2025.105972 |
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