Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle
Among the viruses that encode microRNAs (miRNAs) and infect cattle, such as bovine leukemia virus (BLV), bovine foamy virus (BFV), and Bovine herpesviruses, BLV has gained attention due to the critical role that BLV-miRNAs play in inducing lymphosarcoma in infected animals. BLV is highly prevalent i...
| Autores principales: | , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/24768 https://journals.asm.org/doi/10.1128/spectrum.01755-25 https://doi.org/10.1128/spectrum.01755-25 |
| _version_ | 1855039003709931520 |
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| author | Petersen, Marcos Iván Suarez Archilla, Guillermo Perez, C.V. Gonzalez, Diego D. Trono, Karina Gabriela Mongini, Claudia Jaworski, Juan Pablo Carignano, Hugo Adrian |
| author_browse | Carignano, Hugo Adrian Gonzalez, Diego D. Jaworski, Juan Pablo Mongini, Claudia Perez, C.V. Petersen, Marcos Iván Suarez Archilla, Guillermo Trono, Karina Gabriela |
| author_facet | Petersen, Marcos Iván Suarez Archilla, Guillermo Perez, C.V. Gonzalez, Diego D. Trono, Karina Gabriela Mongini, Claudia Jaworski, Juan Pablo Carignano, Hugo Adrian |
| author_sort | Petersen, Marcos Iván |
| collection | INTA Digital |
| description | Among the viruses that encode microRNAs (miRNAs) and infect cattle, such as bovine leukemia virus (BLV), bovine foamy virus (BFV), and Bovine herpesviruses, BLV has gained attention due to the critical role that BLV-miRNAs play in inducing lymphosarcoma in infected animals. BLV is highly prevalent in the Americas and negatively affects dairy herds, primarily due to restrictions on the commercialization of dairy products from infected animals and a decrease in milk production. Co-infections involving BLV and BFV appear to be common in cattle. Considering the ability of foamy viruses to cross species barriers, preventing their presence within the food chain is essential. We identified the co-expression of seven BLV-derived miRNAs (blv-miR-B1-3p, blv-miR-B2-5p, blv-miR-B2-3p, blv-miR-B3-5p, blv-miR-B3-3p, blv-miR-B4-3p, and blv-miR-B5-5p) and three BFV-derived miRNAs (bfv-miR-BF1-5p, bfv-miR-BF1-3p, and bfv-miR-BF2-5p) in naturally BLV-infected cows. Besides, seven differentially expressed bovine miRNAs (bta-miR-375, bta-miR-133a, bta-miR-677, bta-miR-1, bta-miR-3613a, bta-miR-9-5p, and bta-miR-95) were identified between cows with high BLV proviral load and uninfected counterparts (|fold change| > 1.5 and q-value < 0.05). A comprehensive analysis of protein-protein interaction networks for genes targeted by viral and host-derived miRNAs suggests a functional convergence on key pathways related to immune response, tumorigenesis, and chromatin remodeling. Although BLV- and BFV-derived miRNAs target different genes, these targets participate in shared biological processes. This convergence might reflect a coordinated viral influence on host functions, with implications for disease progression and the increased dissemination of BFV. These findings offer new perspectives for creating diagnostic and treatment approaches to manage viral persistence and tumorigenesis in cattle. |
| format | info:ar-repo/semantics/artículo |
| id | INTA24768 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | INTA247682025-12-26T14:06:44Z Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle Petersen, Marcos Iván Suarez Archilla, Guillermo Perez, C.V. Gonzalez, Diego D. Trono, Karina Gabriela Mongini, Claudia Jaworski, Juan Pablo Carignano, Hugo Adrian Ganado Bovino Enfermedades de los Animales Virus Leucemia Bovina MicroARN Diagnóstico Cattle Animal Diseases Bovine Leukemia Virus MicroRNA Diagnosis Among the viruses that encode microRNAs (miRNAs) and infect cattle, such as bovine leukemia virus (BLV), bovine foamy virus (BFV), and Bovine herpesviruses, BLV has gained attention due to the critical role that BLV-miRNAs play in inducing lymphosarcoma in infected animals. BLV is highly prevalent in the Americas and negatively affects dairy herds, primarily due to restrictions on the commercialization of dairy products from infected animals and a decrease in milk production. Co-infections involving BLV and BFV appear to be common in cattle. Considering the ability of foamy viruses to cross species barriers, preventing their presence within the food chain is essential. We identified the co-expression of seven BLV-derived miRNAs (blv-miR-B1-3p, blv-miR-B2-5p, blv-miR-B2-3p, blv-miR-B3-5p, blv-miR-B3-3p, blv-miR-B4-3p, and blv-miR-B5-5p) and three BFV-derived miRNAs (bfv-miR-BF1-5p, bfv-miR-BF1-3p, and bfv-miR-BF2-5p) in naturally BLV-infected cows. Besides, seven differentially expressed bovine miRNAs (bta-miR-375, bta-miR-133a, bta-miR-677, bta-miR-1, bta-miR-3613a, bta-miR-9-5p, and bta-miR-95) were identified between cows with high BLV proviral load and uninfected counterparts (|fold change| > 1.5 and q-value < 0.05). A comprehensive analysis of protein-protein interaction networks for genes targeted by viral and host-derived miRNAs suggests a functional convergence on key pathways related to immune response, tumorigenesis, and chromatin remodeling. Although BLV- and BFV-derived miRNAs target different genes, these targets participate in shared biological processes. This convergence might reflect a coordinated viral influence on host functions, with implications for disease progression and the increased dissemination of BFV. These findings offer new perspectives for creating diagnostic and treatment approaches to manage viral persistence and tumorigenesis in cattle. Instituto de Virología Fil: Petersen, Marcos Iván. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Petersen, Marcos Iván. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Suarez Archilla, Guillermo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Suarez Archilla, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Perez, C.V. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Perez, C.V. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gonzalez, Diego D..Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Gonzalez, Diego D. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Trono, Karina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Mongini, Claudia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Mongini, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Jaworski, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Jaworski, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Carignano, Hugo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Carignano, Hugo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2025-12-26T13:59:53Z 2025-12-26T13:59:53Z 2025-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/24768 https://journals.asm.org/doi/10.1128/spectrum.01755-25 2165-0497 https://doi.org/10.1128/spectrum.01755-25 eng info:eu-repograntAgreement/INTA/2023-PD-L01-I113, Herramientas de estudio de la Patogenia e Inmunidad en agentes infecciosos y tóxicos que aporten a la sustentabilidad de la producción pecuaria en el marco de Una Salud info:eu-repograntAgreement/INTA/2023-PD-L06-I114, Desarrollo y aplicación de métodos diagnósticos y epidemiológicos para la producción pecuaria sustentable y agroalimentaria en humanos con foco en Una Salud info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Microbiology Spectrum 13 (10) : 1-19 (October 2025) |
| spellingShingle | Ganado Bovino Enfermedades de los Animales Virus Leucemia Bovina MicroARN Diagnóstico Cattle Animal Diseases Bovine Leukemia Virus MicroRNA Diagnosis Petersen, Marcos Iván Suarez Archilla, Guillermo Perez, C.V. Gonzalez, Diego D. Trono, Karina Gabriela Mongini, Claudia Jaworski, Juan Pablo Carignano, Hugo Adrian Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle |
| title | Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle |
| title_full | Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle |
| title_fullStr | Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle |
| title_full_unstemmed | Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle |
| title_short | Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle |
| title_sort | co expression of bovine leukemia virus and bovine foamy virus derived mirnas in naturally infected cattle |
| topic | Ganado Bovino Enfermedades de los Animales Virus Leucemia Bovina MicroARN Diagnóstico Cattle Animal Diseases Bovine Leukemia Virus MicroRNA Diagnosis |
| url | http://hdl.handle.net/20.500.12123/24768 https://journals.asm.org/doi/10.1128/spectrum.01755-25 https://doi.org/10.1128/spectrum.01755-25 |
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