Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf
Bovine brucellosis, caused by Brucella abortus, is a zoonotic disease that leads to abortions in cattle and poses a public health risk. Vaccination with live attenuated strains, including S19 and RB51, is part of control programs. Both vaccines are recommended in calves, and RB51 is used for adult c...
| Autores principales: | , , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/24503 https://www.sciencedirect.com/science/article/abs/pii/S0034528825004187 https://doi.org/10.1016/j.rvsc.2025.105944 |
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| author | Cabaña, Enzo Rejf, Paula Zbrun, Maria Virginia Marini, Maria del Rocio Ilardo, Andres Machado, Selva Garnero, Oscar Foster, Camila Nayla Novoa, María Belén |
| author_browse | Cabaña, Enzo Foster, Camila Nayla Garnero, Oscar Ilardo, Andres Machado, Selva Marini, Maria del Rocio Novoa, María Belén Rejf, Paula Zbrun, Maria Virginia |
| author_facet | Cabaña, Enzo Rejf, Paula Zbrun, Maria Virginia Marini, Maria del Rocio Ilardo, Andres Machado, Selva Garnero, Oscar Foster, Camila Nayla Novoa, María Belén |
| author_sort | Cabaña, Enzo |
| collection | INTA Digital |
| description | Bovine brucellosis, caused by Brucella abortus, is a zoonotic disease that leads to abortions in cattle and poses a public health risk. Vaccination with live attenuated strains, including S19 and RB51, is part of control programs. Both vaccines are recommended in calves, and RB51 is used for adult cattle in endemic herds due to its lack of interference with serological diagnosis. Experimental studies suggest prior S19 vaccination may protect against abortion following RB51 administration during gestation. Here, we report a case of abortion in a dairy cow, sero-negative to Brucella diagnostic assays, previously vaccinated with S19 as a calf and subsequently immunized with RB51 during the first trimester of pregnancy. The cow belongs to a herd infected with B. abortus five years ago, where a plan for eradication of brucellosis is being implemented. The abortion occurred at seven months of gestation, five months after RB51 immunization. Necropsy and histopathology of the fetus revealed systemic lesions consistent with brucellosis. Brucella was isolated from fetal lung and abomasal fluid, and PCR confirmed the isolate as RB51. Serological tests performed on the cow were negative, highlighting the diagnostic limitations in RB51-vaccinated animals. This case represents the first documented abortion caused by RB51 in a cow previously immunized with S19. These findings support the recommendation to avoid RB51 vaccination in pregnant cows to prevent abortion and potential zoonotic transmission. |
| format | info:ar-repo/semantics/artículo |
| id | INTA24503 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA245032025-11-07T11:59:13Z Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf Cabaña, Enzo Rejf, Paula Zbrun, Maria Virginia Marini, Maria del Rocio Ilardo, Andres Machado, Selva Garnero, Oscar Foster, Camila Nayla Novoa, María Belén Ganado de Leche Vacas Lecheras Enfermedades de los Animales Brucelosis Vacunación Aborto Dairy Cattle Dairy Cows Animal Diseases Brucellosis Brucella abortus Vaccination Abortion Bovine brucellosis, caused by Brucella abortus, is a zoonotic disease that leads to abortions in cattle and poses a public health risk. Vaccination with live attenuated strains, including S19 and RB51, is part of control programs. Both vaccines are recommended in calves, and RB51 is used for adult cattle in endemic herds due to its lack of interference with serological diagnosis. Experimental studies suggest prior S19 vaccination may protect against abortion following RB51 administration during gestation. Here, we report a case of abortion in a dairy cow, sero-negative to Brucella diagnostic assays, previously vaccinated with S19 as a calf and subsequently immunized with RB51 during the first trimester of pregnancy. The cow belongs to a herd infected with B. abortus five years ago, where a plan for eradication of brucellosis is being implemented. The abortion occurred at seven months of gestation, five months after RB51 immunization. Necropsy and histopathology of the fetus revealed systemic lesions consistent with brucellosis. Brucella was isolated from fetal lung and abomasal fluid, and PCR confirmed the isolate as RB51. Serological tests performed on the cow were negative, highlighting the diagnostic limitations in RB51-vaccinated animals. This case represents the first documented abortion caused by RB51 in a cow previously immunized with S19. These findings support the recommendation to avoid RB51 vaccination in pregnant cows to prevent abortion and potential zoonotic transmission. EEA Rafaela Fil: Cabaña, Enzo. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Rejf, Paula. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Zbrun, Maria Virginia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Zbrun, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Marini, Maria del Rocio. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Ilardo, Andres. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Machado, Selva. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Garnero, Oscar. Veterinario de Actividad Privada, Santa Fé; Argentina Fil: Foster, Camila Nayla. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Foster, Camila Nayla. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Novoa, María Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Novoa, María Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina 2025-11-07T11:55:14Z 2025-11-07T11:55:14Z 2025-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/24503 https://www.sciencedirect.com/science/article/abs/pii/S0034528825004187 0034-5288 1532-2661 https://doi.org/10.1016/j.rvsc.2025.105944 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Research in Veterinary Science 197 : 105944. (December 2025) |
| spellingShingle | Ganado de Leche Vacas Lecheras Enfermedades de los Animales Brucelosis Vacunación Aborto Dairy Cattle Dairy Cows Animal Diseases Brucellosis Brucella abortus Vaccination Abortion Cabaña, Enzo Rejf, Paula Zbrun, Maria Virginia Marini, Maria del Rocio Ilardo, Andres Machado, Selva Garnero, Oscar Foster, Camila Nayla Novoa, María Belén Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf |
| title | Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf |
| title_full | Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf |
| title_fullStr | Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf |
| title_full_unstemmed | Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf |
| title_short | Abortion associated with Brucella abortus strain RB51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf |
| title_sort | abortion associated with brucella abortus strain rb51 vaccination during gestation in a dairy cow immunized with strain 19 as a calf |
| topic | Ganado de Leche Vacas Lecheras Enfermedades de los Animales Brucelosis Vacunación Aborto Dairy Cattle Dairy Cows Animal Diseases Brucellosis Brucella abortus Vaccination Abortion |
| url | http://hdl.handle.net/20.500.12123/24503 https://www.sciencedirect.com/science/article/abs/pii/S0034528825004187 https://doi.org/10.1016/j.rvsc.2025.105944 |
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