Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination
Phytotherapy represents a promising field for developing new therapeutic strategies, either by acting as antiparasitic agents themselves or by enhancing the efficacy of synthetic drugs. The present study evaluated the in vivo pharmacokinetic and pharmacodynamic interactions following the administrat...
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| Format: | Artículo |
| Language: | Inglés |
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Multidisciplinary Digital Publishing Institute, MDPI
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/24402 https://www.mdpi.com/2076-2615/15/17/2539 https://doi.org/10.3390/ani15172539 |
| _version_ | 1855487318945693696 |
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| author | Miró, María Victoria Ichinose, Paula Lloberas, María Mercedes Moriones, Lucila Lanusse, Carlos Virkel, Guillermo Lifschitz, Adrián |
| author_browse | Ichinose, Paula Lanusse, Carlos Lifschitz, Adrián Lloberas, María Mercedes Miró, María Victoria Moriones, Lucila Virkel, Guillermo |
| author_facet | Miró, María Victoria Ichinose, Paula Lloberas, María Mercedes Moriones, Lucila Lanusse, Carlos Virkel, Guillermo Lifschitz, Adrián |
| author_sort | Miró, María Victoria |
| collection | INTA Digital |
| description | Phytotherapy represents a promising field for developing new therapeutic strategies, either by acting as antiparasitic agents themselves or by enhancing the efficacy of synthetic drugs. The present study evaluated the in vivo pharmacokinetic and pharmacodynamic interactions following the administration of doramectin, either alone or in combination with cinnamaldehyde and pink grapefruit essential oil (CNM–PGF). Additionally, ex vivo P-glycoprotein-mediated interactions were assessed at the intestinal level. Higher efficacy against Haemonchus contortus was observed with the combined treatment of doramectin plus phytochemicals or loperamide. Although phytochemicals and loperamide reduced the ex vivo efflux of rhodamine 123, no pharmacokinetic interactions were detected in vivo. The enhanced efficacy is most likely attributable to localized drug–drug interactions and increased drug availability at the parasite interface. Based on the results obtained, the best treatment would be the combination of DRM with phytochemicals such as CNM–PGF and loperamide. However, a pharmaceutical formulation that allows sustained in vivo interaction between these compounds is needed. |
| format | Artículo |
| id | INTA24402 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Multidisciplinary Digital Publishing Institute, MDPI |
| publisherStr | Multidisciplinary Digital Publishing Institute, MDPI |
| record_format | dspace |
| spelling | INTA244022025-10-31T10:56:25Z Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination Miró, María Victoria Ichinose, Paula Lloberas, María Mercedes Moriones, Lucila Lanusse, Carlos Virkel, Guillermo Lifschitz, Adrián Oveja Nematodos Medicamento Veterinario Farmacología Compuestos Orgánicos Resistencia a los Antihelmínticos Glicoproteínas Ewes Nematodes Trypanocidal Drugs Pharmacology Organic Compounds Resistance to Anthelmintics Glycoproteins Phytotherapy represents a promising field for developing new therapeutic strategies, either by acting as antiparasitic agents themselves or by enhancing the efficacy of synthetic drugs. The present study evaluated the in vivo pharmacokinetic and pharmacodynamic interactions following the administration of doramectin, either alone or in combination with cinnamaldehyde and pink grapefruit essential oil (CNM–PGF). Additionally, ex vivo P-glycoprotein-mediated interactions were assessed at the intestinal level. Higher efficacy against Haemonchus contortus was observed with the combined treatment of doramectin plus phytochemicals or loperamide. Although phytochemicals and loperamide reduced the ex vivo efflux of rhodamine 123, no pharmacokinetic interactions were detected in vivo. The enhanced efficacy is most likely attributable to localized drug–drug interactions and increased drug availability at the parasite interface. Based on the results obtained, the best treatment would be the combination of DRM with phytochemicals such as CNM–PGF and loperamide. However, a pharmaceutical formulation that allows sustained in vivo interaction between these compounds is needed. EEA Balcarce Fil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Ichinose, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Lloberas, Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Lanusse, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina Fil. Virkel, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Lifschitz, Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Comisión de Investigaciones Científicas de la Provincia de Buenos Aires; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina 2025-10-31T10:53:20Z 2025-10-31T10:53:20Z 2025-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/24402 https://www.mdpi.com/2076-2615/15/17/2539 2076-2615 https://doi.org/10.3390/ani15172539 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Multidisciplinary Digital Publishing Institute, MDPI Animals 15 (17) : 2539 (August 2025) |
| spellingShingle | Oveja Nematodos Medicamento Veterinario Farmacología Compuestos Orgánicos Resistencia a los Antihelmínticos Glicoproteínas Ewes Nematodes Trypanocidal Drugs Pharmacology Organic Compounds Resistance to Anthelmintics Glycoproteins Miró, María Victoria Ichinose, Paula Lloberas, María Mercedes Moriones, Lucila Lanusse, Carlos Virkel, Guillermo Lifschitz, Adrián Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination |
| title | Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination |
| title_full | Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination |
| title_fullStr | Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination |
| title_full_unstemmed | Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination |
| title_short | Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination |
| title_sort | phytochemical mediated modulation of doramectin pharmacology in sheep exploring the cinnamaldehyde pink grapefruit combination |
| topic | Oveja Nematodos Medicamento Veterinario Farmacología Compuestos Orgánicos Resistencia a los Antihelmínticos Glicoproteínas Ewes Nematodes Trypanocidal Drugs Pharmacology Organic Compounds Resistance to Anthelmintics Glycoproteins |
| url | http://hdl.handle.net/20.500.12123/24402 https://www.mdpi.com/2076-2615/15/17/2539 https://doi.org/10.3390/ani15172539 |
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