Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2
Bovine leukemia virus (BLV), an oncogenic retrovirus of the genus Deltaretrovirus, causes enzootic bovine leukosis (EBL), the most prevalent neoplastic disease in cattle and a major source of economic loss. While BLV prevalence has been studied in commercial breeds, data on native Latin American cat...
| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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MDPI
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/24212 https://www.mdpi.com/2076-0817/14/10/1005 https://doi.org/10.3390/pathogens14101005 |
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| author | Giovambattista, Guillermo Bao, Aronggaowa Marcuzzi, Olivia Loza Vega, Ariel Jhonny Pereira Rico, Juan A. Ortega Masague, Maria Florencia Castro Rojas, Liz Aurora Martinez, Ruben Dario Reinosa, Odalys Uffo Aida, Yoko |
| author_browse | Aida, Yoko Bao, Aronggaowa Castro Rojas, Liz Aurora Giovambattista, Guillermo Loza Vega, Ariel Jhonny Marcuzzi, Olivia Martinez, Ruben Dario Ortega Masague, Maria Florencia Pereira Rico, Juan A. Reinosa, Odalys Uffo |
| author_facet | Giovambattista, Guillermo Bao, Aronggaowa Marcuzzi, Olivia Loza Vega, Ariel Jhonny Pereira Rico, Juan A. Ortega Masague, Maria Florencia Castro Rojas, Liz Aurora Martinez, Ruben Dario Reinosa, Odalys Uffo Aida, Yoko |
| author_sort | Giovambattista, Guillermo |
| collection | INTA Digital |
| description | Bovine leukemia virus (BLV), an oncogenic retrovirus of the genus Deltaretrovirus, causes enzootic bovine leukosis (EBL), the most prevalent neoplastic disease in cattle and a major source of economic loss. While BLV prevalence has been studied in commercial breeds, data on native Latin American cattle remain limited. This study assessed BLV infection and proviral load in 244 animals from six native breeds: Argentine Creole (CrAr), Patagonian Argentine Creole (CrArPat), Pampa Chaqueño Creole (CrPaCh), Bolivian Creole from Cochabamba (CrCoch), Saavedreño Creole (CrSaa), and Siboney (Sib), sampled across Argentina, Bolivia, Paraguay, and Cuba. BLV-CoCoMo-qPCR-2 assay detected BLV provirus in 76 animals (31.1%), with a mean load of 9923 copies per 105 cells (range: 1–79,740). Infection rates varied significantly by breed (9.8% in CrAr to 83.8% in CrPaCh) and country (15.6% in Argentina to 83.8% in Paraguay) (p = 9.999 × 10−5). Among positives, 57.9% exhibited low proviral load (≤1000 copies), and 13.2% showed moderate levels (1001–9999), suggesting potential resistance to EBL progression. This is the first comprehensive report of BLV proviral load in Creole cattle across Latin America, offering novel epidemiological insights and highlighting the importance of native breeds in BLV surveillance. |
| format | Artículo |
| id | INTA24212 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA242122025-10-20T11:16:21Z Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 Giovambattista, Guillermo Bao, Aronggaowa Marcuzzi, Olivia Loza Vega, Ariel Jhonny Pereira Rico, Juan A. Ortega Masague, Maria Florencia Castro Rojas, Liz Aurora Martinez, Ruben Dario Reinosa, Odalys Uffo Aida, Yoko Virus Leucemia Bovina Ganado Bovino Enfermedades de los Animales Epidemiología Bolivia (Estado Plurinacional de) Bovine Leukemia Virus Cattle Animal Diseases Epidemiology PCR Argentina Bolivia (Plurinational State of) Paraguay Cuba Bovine leukemia virus (BLV), an oncogenic retrovirus of the genus Deltaretrovirus, causes enzootic bovine leukosis (EBL), the most prevalent neoplastic disease in cattle and a major source of economic loss. While BLV prevalence has been studied in commercial breeds, data on native Latin American cattle remain limited. This study assessed BLV infection and proviral load in 244 animals from six native breeds: Argentine Creole (CrAr), Patagonian Argentine Creole (CrArPat), Pampa Chaqueño Creole (CrPaCh), Bolivian Creole from Cochabamba (CrCoch), Saavedreño Creole (CrSaa), and Siboney (Sib), sampled across Argentina, Bolivia, Paraguay, and Cuba. BLV-CoCoMo-qPCR-2 assay detected BLV provirus in 76 animals (31.1%), with a mean load of 9923 copies per 105 cells (range: 1–79,740). Infection rates varied significantly by breed (9.8% in CrAr to 83.8% in CrPaCh) and country (15.6% in Argentina to 83.8% in Paraguay) (p = 9.999 × 10−5). Among positives, 57.9% exhibited low proviral load (≤1000 copies), and 13.2% showed moderate levels (1001–9999), suggesting potential resistance to EBL progression. This is the first comprehensive report of BLV proviral load in Creole cattle across Latin America, offering novel epidemiological insights and highlighting the importance of native breeds in BLV surveillance. EEA Famaillá Fil: Giovambattista, Guillermo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria "Ing. Fernando N. Dulout”; Argentina Fil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Giovambattista, Guillermo. The University of Tokyo. Graduate School of Agricultural and Life Sciences. Laboratory of Global Infectious Diseases Control Science; Japón Fil: Bao, Aronggaowa. The University of Tokyo. Graduate School of Agricultural and Life Sciences. Laboratory of Global Infectious Diseases Control Science; Japón Fil: Marcuzzi, Olivia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Marcuzzi, Olivia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Loza Vega, Ariel Jhonny. Universidad Autónoma Gabriel René Moreno. Facultad de Ciencias Veterinarias; Bolivia Fil: Pereira Rico, Juan A. Universidad Autónoma Gabriel René Moreno. Facultad de Ciencias Veterinarias; Bolivia Fil: Ortega Masague, Maria Florencia. Estación Experimental Agropecuaria Famaillá. Agencia De Extensión Rural Lules; Argentina Fil: Castro Rojas, Liz Aurora. Universidad Nacional de Asunción. Facultad de Ciencias Veterinarias; Paraguay Fil: Martinez, Ruben Dario. Universidad Nacional de Lomas de Zamora. Facultad de Ciencias Agrarias; Argentina Fil: Reinosa, Odalys Uffo. Centro Nacional de Sanidad Agropecuaria (CENSA); Cuba Fil: Aida, Yoko. The University of Tokyo. Graduate School of Agricultural and Life Sciences. Laboratory of Global Infectious Diseases Control Science; Japón 2025-10-20T11:14:19Z 2025-10-20T11:14:19Z 2025-10 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/24212 https://www.mdpi.com/2076-0817/14/10/1005 2076-0817 https://doi.org/10.3390/pathogens14101005 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Pathogens 14 (10) : 1005. (October 2025) |
| spellingShingle | Virus Leucemia Bovina Ganado Bovino Enfermedades de los Animales Epidemiología Bolivia (Estado Plurinacional de) Bovine Leukemia Virus Cattle Animal Diseases Epidemiology PCR Argentina Bolivia (Plurinational State of) Paraguay Cuba Giovambattista, Guillermo Bao, Aronggaowa Marcuzzi, Olivia Loza Vega, Ariel Jhonny Pereira Rico, Juan A. Ortega Masague, Maria Florencia Castro Rojas, Liz Aurora Martinez, Ruben Dario Reinosa, Odalys Uffo Aida, Yoko Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 |
| title | Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 |
| title_full | Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 |
| title_fullStr | Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 |
| title_full_unstemmed | Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 |
| title_short | Detection of Bovine Leukemia Virus in Argentine, Bolivian, Paraguayan and Cuban Native Cattle Using a Quantitative Real-Time PCR Assay-BLV-CoCoMo-qPCR-2 |
| title_sort | detection of bovine leukemia virus in argentine bolivian paraguayan and cuban native cattle using a quantitative real time pcr assay blv cocomo qpcr 2 |
| topic | Virus Leucemia Bovina Ganado Bovino Enfermedades de los Animales Epidemiología Bolivia (Estado Plurinacional de) Bovine Leukemia Virus Cattle Animal Diseases Epidemiology PCR Argentina Bolivia (Plurinational State of) Paraguay Cuba |
| url | http://hdl.handle.net/20.500.12123/24212 https://www.mdpi.com/2076-0817/14/10/1005 https://doi.org/10.3390/pathogens14101005 |
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