Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts

Llama breeding is an important source of economic income for Andean communities, thus ensuring llama biodiversity is fundamental to making breeding decisions that promote sustainable production. Despite this, there is limited information on the genetic diversity of llama populations in Argentina. Mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Anello, Melina, Muzzio, Marina, Silbestro, Miriam B., Daverio, María Silvana, Unzaga, Romina Ines, Romero, Sandra Raquel, Rigalt, Francisco Antonio, Vidal Rioja, Lidia, Di Rocco, Florencia
Formato: info:ar-repo/semantics/artículo
Lenguaje:Español
Publicado: Wiley 2025
Materias:
Acceso en línea:http://hdl.handle.net/20.500.12123/24177
https://onlinelibrary.wiley.com/doi/10.1111/age.70053
https://doi.org/10.1111/age.70053
_version_ 1855038892346966016
author Anello, Melina
Muzzio, Marina
Silbestro, Miriam B.
Daverio, María Silvana
Unzaga, Romina Ines
Romero, Sandra Raquel
Rigalt, Francisco Antonio
Vidal Rioja, Lidia
Di Rocco, Florencia
author_browse Anello, Melina
Daverio, María Silvana
Di Rocco, Florencia
Muzzio, Marina
Rigalt, Francisco Antonio
Romero, Sandra Raquel
Silbestro, Miriam B.
Unzaga, Romina Ines
Vidal Rioja, Lidia
author_facet Anello, Melina
Muzzio, Marina
Silbestro, Miriam B.
Daverio, María Silvana
Unzaga, Romina Ines
Romero, Sandra Raquel
Rigalt, Francisco Antonio
Vidal Rioja, Lidia
Di Rocco, Florencia
author_sort Anello, Melina
collection INTA Digital
description Llama breeding is an important source of economic income for Andean communities, thus ensuring llama biodiversity is fundamental to making breeding decisions that promote sustainable production. Despite this, there is limited information on the genetic diversity of llama populations in Argentina. Moreover, some llama herds in the northwest region of the country exhibit low reproductive efficiency and a high incidence of congenital abnormalities. In this study, we used genotyping by sequencing, a genome-wide approach, to estimate the genetic diversity of Argentine llama populations, assess their conservation status and inbreeding levels, and discuss the impacts on breeding. Overall, our results indicate that current llama populations in the northwest present moderate to high genetic diversity, although a recent reduction in population size was detected for two of them. Population structure was subtle, although three clusters, with some substructure, were recognized. The inbreeding coefficient values were similar for all populations showing moderate to high inbreeding levels. There was a predominance of short homozygous segments, which is indicative of ancient consanguinity. However, recent autozygosity events were evidenced in some llamas with congenital disorders. Thus, we investigated the chromosomal region to find potential candidate genes for such traits. The genes MYO15A and USH1G are proposed as candidates for pigmentation-associated deafness, although further research is needed. This study establishes an initial step towards understanding the genetic diversity of Argentine llamas, highlighting the necessity of reducing current inbreeding levels and implementing continuous monitoring to improve breeding decisions and support a sustainable production system for the species.
format info:ar-repo/semantics/artículo
id INTA24177
institution Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina)
language Español
publishDate 2025
publishDateRange 2025
publishDateSort 2025
publisher Wiley
publisherStr Wiley
record_format dspace
spelling INTA241772025-10-15T14:20:07Z Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts Anello, Melina Muzzio, Marina Silbestro, Miriam B. Daverio, María Silvana Unzaga, Romina Ines Romero, Sandra Raquel Rigalt, Francisco Antonio Vidal Rioja, Lidia Di Rocco, Florencia Genotyping Genotyping-by-Sequencing Breeding Congenital Abnormalities Llamas Genotipado Genotipado Mediante Secuenciación Mejora Anomalía Congénita Llama Genome-wide Analysis South American camelids Sustainable Breeding Análisis de Todo el Genoma Camélido Sudamericano Cría Sostenible Llama breeding is an important source of economic income for Andean communities, thus ensuring llama biodiversity is fundamental to making breeding decisions that promote sustainable production. Despite this, there is limited information on the genetic diversity of llama populations in Argentina. Moreover, some llama herds in the northwest region of the country exhibit low reproductive efficiency and a high incidence of congenital abnormalities. In this study, we used genotyping by sequencing, a genome-wide approach, to estimate the genetic diversity of Argentine llama populations, assess their conservation status and inbreeding levels, and discuss the impacts on breeding. Overall, our results indicate that current llama populations in the northwest present moderate to high genetic diversity, although a recent reduction in population size was detected for two of them. Population structure was subtle, although three clusters, with some substructure, were recognized. The inbreeding coefficient values were similar for all populations showing moderate to high inbreeding levels. There was a predominance of short homozygous segments, which is indicative of ancient consanguinity. However, recent autozygosity events were evidenced in some llamas with congenital disorders. Thus, we investigated the chromosomal region to find potential candidate genes for such traits. The genes MYO15A and USH1G are proposed as candidates for pigmentation-associated deafness, although further research is needed. This study establishes an initial step towards understanding the genetic diversity of Argentine llamas, highlighting the necessity of reducing current inbreeding levels and implementing continuous monitoring to improve breeding decisions and support a sustainable production system for the species. EEA Catamarca Fil: Anello, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Anello, Melina. Universidad Nacional de la Plata (UNLP). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Anello, Melina. Comisión de Investigaciones Científicas (CIC). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Anello, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA). Grupo de Investigaciones en Ecología y Fisiología de Fauna Silvestre (GIEFAS); Argentina Fil: Anello, Melina. Universidad Nacional del Comahue (UNCo). Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA). Grupo de Investigaciones en Ecología y Fisiología de Fauna Silvestre (GIEFAS); Argentina Fil: Muzzio, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Muzzio, Marina. Universidad Nacional de la Plata (UNLP). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Muzzio, Marina. Comisión de Investigaciones Científicas (CIC). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Muzzio, Marina. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Naturales y Museo; Argentina Fil: Silbestro, Miriam B. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Silbestro, Miriam B. Universidad Nacional de la Plata (UNLP). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Silbestro, Miriam B. Comisión de Investigaciones Científicas (CIC). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Daverio, María Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Daverio, María Silvana. Universidad Nacional de la Plata (UNLP). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Daverio, María Silvana. Comisión de Investigaciones Científicas (CIC). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Daverio, Maria Silvana. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas; Argentina Fil: Unzaga, Romina Ines. Poder Judicial de Catamarca. Laboratorio Satélite Forense; Argentina Fil: Romero, Sandra Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación y Desarrollo Tecnológico para la Agricultura Familiar Región NOA; Argentina Fil: Rigalt, Francisco Antonio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Catamarca; Argentina Fil: Vidal Rioja, Lidia. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Vidal Rioja, Lidia. Universidad Nacional de la Plata (UNLP). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Vidal Rioja, Lidia. Comisión de Investigaciones Científicas (CIC). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Di Rocco, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Di Rocco, Florencia. Universidad Nacional de la Plata (UNLP). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina Fil: Di Rocco, Florencia. Comisión de Investigaciones Científicas (CIC). Instituto Multidisciplinario de Biología Celular (IMBICE). Laboratorio de Genética Molecular; Argentina 2025-10-15T14:10:26Z 2025-10-15T14:10:26Z 2025-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/24177 https://onlinelibrary.wiley.com/doi/10.1111/age.70053 1365-2052 0268-9146 https://doi.org/10.1111/age.70053 spa info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Wiley Animal Genetics : 56 (5) : e70053
spellingShingle Genotyping
Genotyping-by-Sequencing
Breeding
Congenital Abnormalities
Llamas
Genotipado
Genotipado Mediante Secuenciación
Mejora
Anomalía Congénita
Llama
Genome-wide Analysis
South American camelids
Sustainable Breeding
Análisis de Todo el Genoma
Camélido Sudamericano
Cría Sostenible
Anello, Melina
Muzzio, Marina
Silbestro, Miriam B.
Daverio, María Silvana
Unzaga, Romina Ines
Romero, Sandra Raquel
Rigalt, Francisco Antonio
Vidal Rioja, Lidia
Di Rocco, Florencia
Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts
title Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts
title_full Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts
title_fullStr Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts
title_full_unstemmed Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts
title_short Genotyping by sequencing-based genetic insights into Argentine llama populations and breeding impacts
title_sort genotyping by sequencing based genetic insights into argentine llama populations and breeding impacts
topic Genotyping
Genotyping-by-Sequencing
Breeding
Congenital Abnormalities
Llamas
Genotipado
Genotipado Mediante Secuenciación
Mejora
Anomalía Congénita
Llama
Genome-wide Analysis
South American camelids
Sustainable Breeding
Análisis de Todo el Genoma
Camélido Sudamericano
Cría Sostenible
url http://hdl.handle.net/20.500.12123/24177
https://onlinelibrary.wiley.com/doi/10.1111/age.70053
https://doi.org/10.1111/age.70053
work_keys_str_mv AT anellomelina genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT muzziomarina genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT silbestromiriamb genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT daveriomariasilvana genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT unzagarominaines genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT romerosandraraquel genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT rigaltfranciscoantonio genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT vidalriojalidia genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts
AT diroccoflorencia genotypingbysequencingbasedgeneticinsightsintoargentinellamapopulationsandbreedingimpacts