Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants
Solanum glaucophyllum is a toxic calcinogenic plant endemic to Central Argentina and is widely recognized as the primary cause of enzootic calcinosis in ruminants. Although the systemic calcification induced by this plant is well documented, its potential impact on reproductive performance remains u...
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
Springer
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/23573 https://link.springer.com/article/10.1007/s11259-025-10857-y https://doi.org/10.1007/s11259-025-10857-y |
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| author | Garcia, Juan Agustin Rodriguez, Alejandro Scioli, Maria Valeria Azaldegui, Ignacio Tiberio, Agustin Pachiani, Martina Vilatuña Lita, Elvis Sosa, Emiliano Canton, German Jose |
| author_browse | Azaldegui, Ignacio Canton, German Jose Garcia, Juan Agustin Pachiani, Martina Rodriguez, Alejandro Scioli, Maria Valeria Sosa, Emiliano Tiberio, Agustin Vilatuña Lita, Elvis |
| author_facet | Garcia, Juan Agustin Rodriguez, Alejandro Scioli, Maria Valeria Azaldegui, Ignacio Tiberio, Agustin Pachiani, Martina Vilatuña Lita, Elvis Sosa, Emiliano Canton, German Jose |
| author_sort | Garcia, Juan Agustin |
| collection | INTA Digital |
| description | Solanum glaucophyllum is a toxic calcinogenic plant endemic to Central Argentina and is widely recognized as the primary cause of enzootic calcinosis in ruminants. Although the systemic calcification induced by this plant is well documented, its potential impact on reproductive performance remains underexplored. The present study reports the first evidence of calcinosis affecting the female reproductive organs of ruminants. Reproductive tissues-including the uterus, ovary, and oviduct-were obtained from a non-pregnant 4-year-old Texel ewe and a 6-year-old Hereford cow that exhibited gross signs of systemic calcification following S. glaucophyllum ingestion. Histopathological examination revealed extensive granular basophilic calcium deposits within the tunica media and/or intima of blood vessels in these organs, accompanied by varying degrees of non-mineralized hyperplasia. The deposits were confirmed as calcium by Von Kossa staining. These findings suggest that vascular calcification in reproductive tissues may reduce blood flow, thereby impairing the delivery of hormones essential for follicular growth, ovulation, fertilization, and embryo implantation. Given that subclinical calcinosis may compromise reproductive efficiency, this phenomenon could have significant economic repercussions for the livestock industry. Further investigations are warranted to quantitatively assess the degree of calcification, vascular perfusion, and additional reproductive parameters to elucidate the impact of S. glaucophyllum-induced calcinosis on fertility. |
| format | Artículo |
| id | INTA23573 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | INTA235732025-08-27T10:15:05Z Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants Garcia, Juan Agustin Rodriguez, Alejandro Scioli, Maria Valeria Azaldegui, Ignacio Tiberio, Agustin Pachiani, Martina Vilatuña Lita, Elvis Sosa, Emiliano Canton, German Jose Plantas Tóxicas Rumiante Calcificación Patológica Aparato Reproductor Enfermedades de los Animales América del Sur Poisonous Plants Ruminants Calcinosis Reproductive System Animal Diseases South America Solanum glaucophyllum Solanum glaucophyllum is a toxic calcinogenic plant endemic to Central Argentina and is widely recognized as the primary cause of enzootic calcinosis in ruminants. Although the systemic calcification induced by this plant is well documented, its potential impact on reproductive performance remains underexplored. The present study reports the first evidence of calcinosis affecting the female reproductive organs of ruminants. Reproductive tissues-including the uterus, ovary, and oviduct-were obtained from a non-pregnant 4-year-old Texel ewe and a 6-year-old Hereford cow that exhibited gross signs of systemic calcification following S. glaucophyllum ingestion. Histopathological examination revealed extensive granular basophilic calcium deposits within the tunica media and/or intima of blood vessels in these organs, accompanied by varying degrees of non-mineralized hyperplasia. The deposits were confirmed as calcium by Von Kossa staining. These findings suggest that vascular calcification in reproductive tissues may reduce blood flow, thereby impairing the delivery of hormones essential for follicular growth, ovulation, fertilization, and embryo implantation. Given that subclinical calcinosis may compromise reproductive efficiency, this phenomenon could have significant economic repercussions for the livestock industry. Further investigations are warranted to quantitatively assess the degree of calcification, vascular perfusion, and additional reproductive parameters to elucidate the impact of S. glaucophyllum-induced calcinosis on fertility. EEA Balcarce Fil: García, Juan Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Rodríguez, Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Cuenca del Salado; Argentina Fil: Scioli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Azaldegui, Ignacio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Tiberio, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Cuenca del Salado; Argentina Fil: Pachiani, Martina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Vilatuña, Elvis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Sosa, Emiliano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina 2025-08-27T10:02:56Z 2025-08-27T10:02:56Z 2025-08-22 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/23573 https://link.springer.com/article/10.1007/s11259-025-10857-y 1573-7446 (online) 0165-7380 (print) https://doi.org/10.1007/s11259-025-10857-y eng info:eu-repograntAgreement/INTA/2023-PD-L01-I113, Herramientas de estudio de la Patogenia e Inmunidad en agentes infecciosos y tóxicos que aporten a la sustentabilidad de la producción pecuaria en el marco de Una Salud info:eu-repograntAgreement/INTA/2019-RIST-E5-I111-001, Laboratorios de Diagnóstico Veterinario info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Springer Veterinary Research Communications 49 : 284 (August 2025) |
| spellingShingle | Plantas Tóxicas Rumiante Calcificación Patológica Aparato Reproductor Enfermedades de los Animales América del Sur Poisonous Plants Ruminants Calcinosis Reproductive System Animal Diseases South America Solanum glaucophyllum Garcia, Juan Agustin Rodriguez, Alejandro Scioli, Maria Valeria Azaldegui, Ignacio Tiberio, Agustin Pachiani, Martina Vilatuña Lita, Elvis Sosa, Emiliano Canton, German Jose Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants |
| title | Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants |
| title_full | Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants |
| title_fullStr | Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants |
| title_full_unstemmed | Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants |
| title_short | Potential reproductive impairment due to Solanum glaucophyllum-induced calcinosis in female ruminants |
| title_sort | potential reproductive impairment due to solanum glaucophyllum induced calcinosis in female ruminants |
| topic | Plantas Tóxicas Rumiante Calcificación Patológica Aparato Reproductor Enfermedades de los Animales América del Sur Poisonous Plants Ruminants Calcinosis Reproductive System Animal Diseases South America Solanum glaucophyllum |
| url | http://hdl.handle.net/20.500.12123/23573 https://link.springer.com/article/10.1007/s11259-025-10857-y https://doi.org/10.1007/s11259-025-10857-y |
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