TunR2, a novel mode-of-action tunicamycin-type antibiotic : Pharmacokinetics in C57BL/6 mouse and Holstein cattle

We have investigated the pharmacokinetics of TunR2, a modified tunicamycin-type antibiotic, in mice and cattle. TunR2 has previously been shown to be effective in a mycobacterial disease model using zebrafish, with a minimal activation of the eukaryotic unfolded protein response (upr) and a reductio...

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Autores principales:	Colombatti Olivieri, Maria Alejandra, Cassmann, Eric D., Jackson, Michael A., Price, Neil P. J., Bannantine, John P.
Formato:	Artículo
Lenguaje:	Inglés
Publicado:	Public Library of Science 2025
Materias:	Antibiotics Pharmacokinetics Mycobacterium Infectious Diseases Antimicrobials Mice Antibióticos Farmacocinética Enfermedades Infecciosas Antimicrobianos Ratón Holstein Cattle Ganado Holstein
Acceso en línea:	http://hdl.handle.net/20.500.12123/23447 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0327932 https://doi.org/10.1371/journal.pone.0327932