Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America
The conservation of animal genetic resources refers to measures taken to prevent the loss of genetic diversity in livestock populations, including the protection of breeds from extinction. Creole cattle populations have suffered a drastic reduction in recent decades owing to absorbent crosses or rep...
| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2025
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/23166 https://onlinelibrary.wiley.com/doi/10.1111/age.13435 https://doi.org/10.1111/age.13435 |
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| author | Marcuzzi, Olivia Calcaterra, Francisco Loza Vega, Ariel Jhonny Ortega Masague, Maria Florencia Armstrong, Eileen Pereira Rico, Juan A. Jara Tellechea, Eugenio Salvador Olivera, L. Hernán Peral Garcia, Pilar Giovambattista, Guillermo |
| author_browse | Armstrong, Eileen Calcaterra, Francisco Giovambattista, Guillermo Jara Tellechea, Eugenio Salvador Loza Vega, Ariel Jhonny Marcuzzi, Olivia Olivera, L. Hernán Ortega Masague, Maria Florencia Peral Garcia, Pilar Pereira Rico, Juan A. |
| author_facet | Marcuzzi, Olivia Calcaterra, Francisco Loza Vega, Ariel Jhonny Ortega Masague, Maria Florencia Armstrong, Eileen Pereira Rico, Juan A. Jara Tellechea, Eugenio Salvador Olivera, L. Hernán Peral Garcia, Pilar Giovambattista, Guillermo |
| author_sort | Marcuzzi, Olivia |
| collection | INTA Digital |
| description | The conservation of animal genetic resources refers to measures taken to prevent the loss of genetic diversity in livestock populations, including the protection of breeds from extinction. Creole cattle populations have suffered a drastic reduction in recent decades owing to absorbent crosses or replacement with commercial breeds of European or Indian origin. Genetic characterization can serve as a source of information for conservation strategies to maintain genetic variation. The objective of this work was to evaluate the levels of inbreeding and kinship through the use of genomic information. A total of 903 DNAs from 13 cattle populations from Argentina, Bolivia and Uruguay were genotyped using an SNP panel of 48 K. Also, a dataset of 76 K SNPs from Peruvian Creole was included. Two inbreeding indices (FROH and Fhat2) and kinship relationships were calculated. In addition, effective population size (Ne), linkage disequilibrium, population composition and phylogenetic relationships were estimated. In Creole cattle, FROH ranged from 0.14 to 0.03, and Fhat2 was close to zero. The inferred Ne trends exhibited a decline toward the present for all populations, whereas Creole cattle presented a lower magnitude of Ne than foreign breeds. Cluster analysis clearly differentiated the taurine and Zebu components (K2) and showed that Bolivian Creole cattle presented Zebu gene introgression. Despite the population reduction, Creole populations did not present extreme values of consanguinity and kinship and maintain high levels of genetic diversity. The information obtained in this work may be useful for planning conservation programmes for these valuable local animal genetic resources. |
| format | Artículo |
| id | INTA23166 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA231662025-07-25T11:59:42Z Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America Marcuzzi, Olivia Calcaterra, Francisco Loza Vega, Ariel Jhonny Ortega Masague, Maria Florencia Armstrong, Eileen Pereira Rico, Juan A. Jara Tellechea, Eugenio Salvador Olivera, L. Hernán Peral Garcia, Pilar Giovambattista, Guillermo Ganado Bovino Característica Genómica Endogamia Variación Genética América del Sur Cattle Genomic Features Inbreeding Genetic Variation South America Genetic Resources Conservation Conservación de Recursos Genéticos Ganado Criollo Creole Cattle The conservation of animal genetic resources refers to measures taken to prevent the loss of genetic diversity in livestock populations, including the protection of breeds from extinction. Creole cattle populations have suffered a drastic reduction in recent decades owing to absorbent crosses or replacement with commercial breeds of European or Indian origin. Genetic characterization can serve as a source of information for conservation strategies to maintain genetic variation. The objective of this work was to evaluate the levels of inbreeding and kinship through the use of genomic information. A total of 903 DNAs from 13 cattle populations from Argentina, Bolivia and Uruguay were genotyped using an SNP panel of 48 K. Also, a dataset of 76 K SNPs from Peruvian Creole was included. Two inbreeding indices (FROH and Fhat2) and kinship relationships were calculated. In addition, effective population size (Ne), linkage disequilibrium, population composition and phylogenetic relationships were estimated. In Creole cattle, FROH ranged from 0.14 to 0.03, and Fhat2 was close to zero. The inferred Ne trends exhibited a decline toward the present for all populations, whereas Creole cattle presented a lower magnitude of Ne than foreign breeds. Cluster analysis clearly differentiated the taurine and Zebu components (K2) and showed that Bolivian Creole cattle presented Zebu gene introgression. Despite the population reduction, Creole populations did not present extreme values of consanguinity and kinship and maintain high levels of genetic diversity. The information obtained in this work may be useful for planning conservation programmes for these valuable local animal genetic resources. Instituto de Investigación Animal del Chaco Semiárido Fil: Marcuzzi, Olivia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Marcuzzi, Olivia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Calcaterra, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Calcaterra, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Loza Vega, Ariel Jhonny. Universidad Autónoma Gabriel René Moreno. Facultad de Ciencias Veterinarias; Bolivia Fil: Ortega Masague, Maria Florencia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido; Argentina Fil: Armstrong, Eileen. Universidad de la República. Facultad de Veterinaria. Unidad Académica Genética y Mejora Animal. Departamento de Producción Animal; Uruguay Fil: Pereira Rico, Juan A. Universidad Autónoma Gabriel René Moreno. Facultad de Ciencias Veterinarias; Bolivia Fil: Jara Tellechea, Eugenio Salvador. Universidad de la República. Facultad de Veterinaria. Unidad Académica Genética y Mejora Animal. Departamento de Producción Animal; Uruguay Fil: Olivera, L. Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Olivera, L. Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Peral Garcia, Pilar. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina Fil: Giovambattista, Guillermo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria "Ing. Fernando N. Dulout”; Argentina Fil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Genética Veterinaria ‘Ing. Fernando N. Dulout’; Argentina 2025-07-25T11:55:55Z 2025-07-25T11:55:55Z 2024-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/23166 https://onlinelibrary.wiley.com/doi/10.1111/age.13435 0268-9146 1365-2052 https://doi.org/10.1111/age.13435 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Wiley Animal Genetics 55 (4) : 527-539. (August 2024) |
| spellingShingle | Ganado Bovino Característica Genómica Endogamia Variación Genética América del Sur Cattle Genomic Features Inbreeding Genetic Variation South America Genetic Resources Conservation Conservación de Recursos Genéticos Ganado Criollo Creole Cattle Marcuzzi, Olivia Calcaterra, Francisco Loza Vega, Ariel Jhonny Ortega Masague, Maria Florencia Armstrong, Eileen Pereira Rico, Juan A. Jara Tellechea, Eugenio Salvador Olivera, L. Hernán Peral Garcia, Pilar Giovambattista, Guillermo Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America |
| title | Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America |
| title_full | Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America |
| title_fullStr | Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America |
| title_full_unstemmed | Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America |
| title_short | Genomic analysis of inbreeding level, kinship and breed relationships in Creole cattle from South America |
| title_sort | genomic analysis of inbreeding level kinship and breed relationships in creole cattle from south america |
| topic | Ganado Bovino Característica Genómica Endogamia Variación Genética América del Sur Cattle Genomic Features Inbreeding Genetic Variation South America Genetic Resources Conservation Conservación de Recursos Genéticos Ganado Criollo Creole Cattle |
| url | http://hdl.handle.net/20.500.12123/23166 https://onlinelibrary.wiley.com/doi/10.1111/age.13435 https://doi.org/10.1111/age.13435 |
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