B cell and antibody responses in bovine tuberculosis
The development of vaccines and effective diagnostic methods for bovine tuberculosis requires an understanding of the immune response against its causative agent, Mycobacterium bovis. Although this disease is primarily investigated and diagnosed through the assessment of cell-mediated immunity, the...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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MDPI
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/23112 https://www.mdpi.com/2073-4468/13/4/84 https://doi.org/10.3390/antib13040084 |
| _version_ | 1855487068807888896 |
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| author | Klepp, Laura Ines Blanco, Federico Carlos Bigi, María Mercedes Vazquez, Cristina Lourdes Garcia, Elizabeth Andrea Sabio Y Garcia, Julia Veronica Bigi, Fabiana |
| author_browse | Bigi, Fabiana Bigi, María Mercedes Blanco, Federico Carlos Garcia, Elizabeth Andrea Klepp, Laura Ines Sabio Y Garcia, Julia Veronica Vazquez, Cristina Lourdes |
| author_facet | Klepp, Laura Ines Blanco, Federico Carlos Bigi, María Mercedes Vazquez, Cristina Lourdes Garcia, Elizabeth Andrea Sabio Y Garcia, Julia Veronica Bigi, Fabiana |
| author_sort | Klepp, Laura Ines |
| collection | INTA Digital |
| description | The development of vaccines and effective diagnostic methods for bovine tuberculosis requires an understanding of the immune response against its causative agent, Mycobacterium bovis. Although this disease is primarily investigated and diagnosed through the assessment of cell-mediated immunity, the role of B cells and antibodies in bovine tuberculosis has been relatively undervalued and understudied. Current evidence indicates that circulating M. bovis-specific antibodies are not effective in controlling the disease. However, local humoral immune responses may contribute to either defence or pathology. Recent studies in animal models and cattle vaccine trials suggest a potential beneficial role of B cells in tuberculosis control. This review discusses the role of B cells and antibodies in bovine tuberculosis and explores antibody-based diagnostics for the disease, including traditional techniques, such as different ELISA, new platforms based on multiple antigens and point-of-care technologies. The high specificity and sensitivity values achieved by numerous antibody-based tests support their use as complementary tests for the diagnosis of bovine tuberculosis, especially for identifying infected animals that may be missed by the official tests. |
| format | Artículo |
| id | INTA23112 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA231122025-07-23T10:39:14Z B cell and antibody responses in bovine tuberculosis Klepp, Laura Ines Blanco, Federico Carlos Bigi, María Mercedes Vazquez, Cristina Lourdes Garcia, Elizabeth Andrea Sabio Y Garcia, Julia Veronica Bigi, Fabiana Bovine Tuberculosis Antibodies Ganado Bovino Immune Response Tuberculosis Bovina Mycobacterium bovis Anticuerpos Cattle Respuesta Inmunológica The development of vaccines and effective diagnostic methods for bovine tuberculosis requires an understanding of the immune response against its causative agent, Mycobacterium bovis. Although this disease is primarily investigated and diagnosed through the assessment of cell-mediated immunity, the role of B cells and antibodies in bovine tuberculosis has been relatively undervalued and understudied. Current evidence indicates that circulating M. bovis-specific antibodies are not effective in controlling the disease. However, local humoral immune responses may contribute to either defence or pathology. Recent studies in animal models and cattle vaccine trials suggest a potential beneficial role of B cells in tuberculosis control. This review discusses the role of B cells and antibodies in bovine tuberculosis and explores antibody-based diagnostics for the disease, including traditional techniques, such as different ELISA, new platforms based on multiple antigens and point-of-care technologies. The high specificity and sensitivity values achieved by numerous antibody-based tests support their use as complementary tests for the diagnosis of bovine tuberculosis, especially for identifying infected animals that may be missed by the official tests. Instituto de Biotecnología Fil: Klepp, Laura Ines. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Klepp, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bigi, María Mercedes. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones Biomédicas; Argentina Fil: Bigi, María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vazquez, Cristina Lourdes. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Vazquez, Cristina Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Garcia, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Sabio Y Garcia, Julia Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Sabio Y Garcia, Julia Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Bigi, Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2025-07-23T10:22:52Z 2025-07-23T10:22:52Z 2024-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/23112 https://www.mdpi.com/2073-4468/13/4/84 2073-4468 https://doi.org/10.3390/antib13040084 eng info:eu-repograntAgreement/INTA/2023-PD-L06-I116, Implementación de tecnologías y nuevas estrategias preventivas y terapéuticas para el desarrollo sustentable y eficiente de la producción animal en el marco de Una Salud info:eu-repograntAgreement/INTA/2023-PD-L06-I114, Desarrollo y aplicación de métodos diagnósticos y epidemiológicos para la producción pecuaria sustentable y agroalimentaria en humanos con foco en Una Salud info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Antibodies 13 (4) : 84 (December 2024) |
| spellingShingle | Bovine Tuberculosis Antibodies Ganado Bovino Immune Response Tuberculosis Bovina Mycobacterium bovis Anticuerpos Cattle Respuesta Inmunológica Klepp, Laura Ines Blanco, Federico Carlos Bigi, María Mercedes Vazquez, Cristina Lourdes Garcia, Elizabeth Andrea Sabio Y Garcia, Julia Veronica Bigi, Fabiana B cell and antibody responses in bovine tuberculosis |
| title | B cell and antibody responses in bovine tuberculosis |
| title_full | B cell and antibody responses in bovine tuberculosis |
| title_fullStr | B cell and antibody responses in bovine tuberculosis |
| title_full_unstemmed | B cell and antibody responses in bovine tuberculosis |
| title_short | B cell and antibody responses in bovine tuberculosis |
| title_sort | b cell and antibody responses in bovine tuberculosis |
| topic | Bovine Tuberculosis Antibodies Ganado Bovino Immune Response Tuberculosis Bovina Mycobacterium bovis Anticuerpos Cattle Respuesta Inmunológica |
| url | http://hdl.handle.net/20.500.12123/23112 https://www.mdpi.com/2073-4468/13/4/84 https://doi.org/10.3390/antib13040084 |
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