An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
Poster
| Main Authors: | , , , , |
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| Format: | info:ar-repo/semantics/documento de conferencia |
| Language: | Inglés |
| Published: |
Universidad Nacional del Centro de la Provincia de Buenos Aires
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/23026 |
| _version_ | 1855038683322777600 |
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| author | Rossi, Ursula Amaranta Maurizio, Estefanía Caffaro, María Eugenia Poli, Mario Andres Rossetti, Carlos Alberto |
| author_browse | Caffaro, María Eugenia Maurizio, Estefanía Poli, Mario Andres Rossetti, Carlos Alberto Rossi, Ursula Amaranta |
| author_facet | Rossi, Ursula Amaranta Maurizio, Estefanía Caffaro, María Eugenia Poli, Mario Andres Rossetti, Carlos Alberto |
| author_sort | Rossi, Ursula Amaranta |
| collection | INTA Digital |
| description | Poster |
| format | info:ar-repo/semantics/documento de conferencia |
| id | INTA23026 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Universidad Nacional del Centro de la Provincia de Buenos Aires |
| publisherStr | Universidad Nacional del Centro de la Provincia de Buenos Aires |
| record_format | dspace |
| spelling | INTA230262025-07-15T13:12:10Z An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection Rossi, Ursula Amaranta Maurizio, Estefanía Caffaro, María Eugenia Poli, Mario Andres Rossetti, Carlos Alberto Brucella melitensis Macrófago Caprinae Caprinos Interferona Citoquina Respuesta Inmunológica Organismo patógeno Macrophages Goats Interferons Cytokines Immune Response Pathogens Poster Brucella melitensis is the etiological agent of brucellosis in goats and the main cause of human brucellosis. Interferons (IFNs) are important cytokines in the immune responses to intracellular pathogens and tumor cells. Although IFNβ is classically associated with antiviral responses, growing evidence shows that IFNβ is also involved in the cellular response to bacterial infections. IRF3 is a member of the interferon regulatory transcription factor family that plays a critical role in both the early and late phases of the IFNα/β gene induction. In general, it is considered that IRF3 acts as a suppressor of pro-inflammatory genes and an enhancer of anti inflammatory genes. For example, IRF3 can be directly recruited to the IL12B promoter suppressing its expression. It was reported that B. abortus induces IFNβ expression in an IRF3-dependent manner, and that mice lacking the IFNα/β receptor are more resistant to Brucella infection. Instituto de Patobiología Fil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Rossi, Ursula Amaranta. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina Fil: Maurizio, Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Maurizio, Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina Fil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; Argentina Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; Argentina Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Rossetti, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina 2025-07-15T12:54:51Z 2025-07-15T12:54:51Z 2023-08 info:ar-repo/semantics/documento de conferencia info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/23026 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Universidad Nacional del Centro de la Provincia de Buenos Aires II Congreso de Microbiología Veterinaria, Facultad de Ciencias Veterinarias, Universidad del Centro de la Provincia de Buenos Aires, 9 al 12 de agosto 2023 |
| spellingShingle | Brucella melitensis Macrófago Caprinae Caprinos Interferona Citoquina Respuesta Inmunológica Organismo patógeno Macrophages Goats Interferons Cytokines Immune Response Pathogens Rossi, Ursula Amaranta Maurizio, Estefanía Caffaro, María Eugenia Poli, Mario Andres Rossetti, Carlos Alberto An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection |
| title | An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection |
| title_full | An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection |
| title_fullStr | An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection |
| title_full_unstemmed | An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection |
| title_short | An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection |
| title_sort | insertion in the caprine irf3 gene affects macrophage response to b melitensis infection |
| topic | Brucella melitensis Macrófago Caprinae Caprinos Interferona Citoquina Respuesta Inmunológica Organismo patógeno Macrophages Goats Interferons Cytokines Immune Response Pathogens |
| url | http://hdl.handle.net/20.500.12123/23026 |
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