Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
Fowl typhoid (FT) caused by Salmonella Gallinarum (SG) is a poultry disease distributed worldwide that has been eradicated in commercial production of many developed countries but still persists in many developing countries. Vaccination is one of the main strategies to reduce mortality, clinical sig...
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| Format: | Artículo |
| Language: | Inglés |
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American Association of Avian Pathologists
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/22998 https://bioone.org/journals/avian-diseases/volume-68/issue-3/aviandiseases-D-24-00024/Combination-of-Live-and-Inactivated-Salmonella-Vaccines-to-Protect-Against/10.1637/aviandiseases-D-24-00024.short https://doi.org/10.1637/aviandiseases-D-24-00024 |
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| author | Joaquim, Patricia Estefania Balbiani, Facundo Socas, Maria Laura Morales, Hernando Casey, Marcos Rubio, Jesus Chacana, Pablo |
| author_browse | Balbiani, Facundo Casey, Marcos Chacana, Pablo Joaquim, Patricia Estefania Morales, Hernando Rubio, Jesus Socas, Maria Laura |
| author_facet | Joaquim, Patricia Estefania Balbiani, Facundo Socas, Maria Laura Morales, Hernando Casey, Marcos Rubio, Jesus Chacana, Pablo |
| author_sort | Joaquim, Patricia Estefania |
| collection | INTA Digital |
| description | Fowl typhoid (FT) caused by Salmonella Gallinarum (SG) is a poultry disease distributed worldwide that has been eradicated in commercial production of many developed countries but still persists in many developing countries. Vaccination is one of the main strategies to reduce mortality, clinical signs, and vertical or horizontal transmission. The aim of this work was to assess the protection against FT conferred by vaccines based on Salmonella Enteritidis (SE), SG, or a combination. Five experimental groups of birds, vaccinated with different live or inactivated SG and SE vaccines were included in the trial: 1) two doses of a SG-SE bivalent inactivated vaccine; 2) four doses of the live attenuated SE vaccine; 3) three doses of the live attenuated SE vaccine and two doses of the SG-SE bivalent inactivated vaccine; 4) two doses of the live attenuated SG9R vaccine; and 5) unvaccinated birds. At 28 wk of age, all hens were challenged with a virulent strain of SG, and mortality was recorded during the subsequent 15 days. The results showed that the plan that included only the inactivated vaccine did not show significant protection (P = 1), while the plan based on the administration of the attenuated strain of SE significantly reduced mortality in the group of birds (P = 0.0309). However, the highest levels of protection were obtained in the group of hens immunized with the combination of the inactivated vaccine and the live attenuated SE strain (P < 0.0001), which was statistically similar to the homologous protection conferred by the SG 9R strain, a vaccine used in many countries to control FT. These results demonstrate that the combination of existing vaccines together with strict biosecurity measures on farms may help improve the control of the pathogen in countries where FT in an emerging or reemerging disease. |
| format | Artículo |
| id | INTA22998 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | American Association of Avian Pathologists |
| publisherStr | American Association of Avian Pathologists |
| record_format | dspace |
| spelling | INTA229982025-07-11T14:59:55Z Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens Joaquim, Patricia Estefania Balbiani, Facundo Socas, Maria Laura Morales, Hernando Casey, Marcos Rubio, Jesus Chacana, Pablo Salmonella gallinarum Tifosis Aviar Vacuna Gallina Ponedora Protección Fowl Typhoid Vaccines Layer Chickens Protection Fowl typhoid (FT) caused by Salmonella Gallinarum (SG) is a poultry disease distributed worldwide that has been eradicated in commercial production of many developed countries but still persists in many developing countries. Vaccination is one of the main strategies to reduce mortality, clinical signs, and vertical or horizontal transmission. The aim of this work was to assess the protection against FT conferred by vaccines based on Salmonella Enteritidis (SE), SG, or a combination. Five experimental groups of birds, vaccinated with different live or inactivated SG and SE vaccines were included in the trial: 1) two doses of a SG-SE bivalent inactivated vaccine; 2) four doses of the live attenuated SE vaccine; 3) three doses of the live attenuated SE vaccine and two doses of the SG-SE bivalent inactivated vaccine; 4) two doses of the live attenuated SG9R vaccine; and 5) unvaccinated birds. At 28 wk of age, all hens were challenged with a virulent strain of SG, and mortality was recorded during the subsequent 15 days. The results showed that the plan that included only the inactivated vaccine did not show significant protection (P = 1), while the plan based on the administration of the attenuated strain of SE significantly reduced mortality in the group of birds (P = 0.0309). However, the highest levels of protection were obtained in the group of hens immunized with the combination of the inactivated vaccine and the live attenuated SE strain (P < 0.0001), which was statistically similar to the homologous protection conferred by the SG 9R strain, a vaccine used in many countries to control FT. These results demonstrate that the combination of existing vaccines together with strict biosecurity measures on farms may help improve the control of the pathogen in countries where FT in an emerging or reemerging disease. Instituto de Patobiología Fil: Joaquim, Patricia Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Joaquim, Patricia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Balbiani, Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Balbiani, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Socas, Maria Laura. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Socas, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Morales, Hernando. CALIER; España Fil: Casey, Marcos. CALIER; España Fil: Rubio, Jesus. CALIER; España Fil: Chacana, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Chacana, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2025-07-11T14:47:48Z 2025-07-11T14:47:48Z 2024-09 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/20.500.12123/22998 https://bioone.org/journals/avian-diseases/volume-68/issue-3/aviandiseases-D-24-00024/Combination-of-Live-and-Inactivated-Salmonella-Vaccines-to-Protect-Against/10.1637/aviandiseases-D-24-00024.short 0005-2086 1938-4351 https://doi.org/10.1637/aviandiseases-D-24-00024 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf American Association of Avian Pathologists Avian Diseases 68 (3) : 259-262 (September 2024) |
| spellingShingle | Salmonella gallinarum Tifosis Aviar Vacuna Gallina Ponedora Protección Fowl Typhoid Vaccines Layer Chickens Protection Joaquim, Patricia Estefania Balbiani, Facundo Socas, Maria Laura Morales, Hernando Casey, Marcos Rubio, Jesus Chacana, Pablo Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens |
| title | Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens |
| title_full | Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens |
| title_fullStr | Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens |
| title_full_unstemmed | Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens |
| title_short | Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens |
| title_sort | combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens |
| topic | Salmonella gallinarum Tifosis Aviar Vacuna Gallina Ponedora Protección Fowl Typhoid Vaccines Layer Chickens Protection |
| url | http://hdl.handle.net/20.500.12123/22998 https://bioone.org/journals/avian-diseases/volume-68/issue-3/aviandiseases-D-24-00024/Combination-of-Live-and-Inactivated-Salmonella-Vaccines-to-Protect-Against/10.1637/aviandiseases-D-24-00024.short https://doi.org/10.1637/aviandiseases-D-24-00024 |
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