Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues
Huanglongbing (HLB), caused mainly by Candidatus Liberibacter asiaticus (CLas), is a devastating disease threatening citrus production worldwide, leading to leaf mottling, fruit deformation, and significant yield losses. This study generated a comprehensive co-expression network analysis using RNA-s...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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MDPI
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/22675 https://www.mdpi.com/2223-7747/14/12/1792 https://doi.org/10.3390/plants14121792 |
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| author | Machado, Rodrigo Moschen, Sebastian Nicolas Conti, Gabriela Gonzalez, Sergio Alberto Rivarola, Maximo Lisandro Gomez, Claudio Andres Hopp, Horacio Esteban Fernandez, Paula Del Carmen |
| author_browse | Conti, Gabriela Fernandez, Paula Del Carmen Gomez, Claudio Andres Gonzalez, Sergio Alberto Hopp, Horacio Esteban Machado, Rodrigo Moschen, Sebastian Nicolas Rivarola, Maximo Lisandro |
| author_facet | Machado, Rodrigo Moschen, Sebastian Nicolas Conti, Gabriela Gonzalez, Sergio Alberto Rivarola, Maximo Lisandro Gomez, Claudio Andres Hopp, Horacio Esteban Fernandez, Paula Del Carmen |
| author_sort | Machado, Rodrigo |
| collection | INTA Digital |
| description | Huanglongbing (HLB), caused mainly by Candidatus Liberibacter asiaticus (CLas), is a devastating disease threatening citrus production worldwide, leading to leaf mottling, fruit deformation, and significant yield losses. This study generated a comprehensive co-expression network analysis using RNA-seq data from 17 public datasets. Weighted gene co-expression network analysis (WGCNA) was applied to identify gene modules associated with citrus species, tissue types, and days post-infection (DPIs). These modules revealed significant enrichment in biological pathways related to stress responses, metabolic reprograming, ribosomal protein synthesis, chloroplast and plastid function, cellular architecture, and intracellular transport. The results offer a molecular framework for understanding HLB pathogenesis and host response. By elucidating module-specific functions and their correlation with species- and tissue-specific responses, this study provides a robust foundation for identifying key genetic targets. These insights facilitate breeding programs focused on developing HLB-tolerant citrus cultivars, contributing to the long-term sustainability and resilience of global citrus production. |
| format | info:ar-repo/semantics/artículo |
| id | INTA22675 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA226752025-06-13T13:16:38Z Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues Machado, Rodrigo Moschen, Sebastian Nicolas Conti, Gabriela Gonzalez, Sergio Alberto Rivarola, Maximo Lisandro Gomez, Claudio Andres Hopp, Horacio Esteban Fernandez, Paula Del Carmen Citrus Plant Diseases Huanglongbing Genetics Disease Tolerance Enfermedades de las Plantas Huanglongbing de los Cítricos Genética Tolerancia a Enfermedades HLB Candidatus Liberibacter Huanglongbing (HLB), caused mainly by Candidatus Liberibacter asiaticus (CLas), is a devastating disease threatening citrus production worldwide, leading to leaf mottling, fruit deformation, and significant yield losses. This study generated a comprehensive co-expression network analysis using RNA-seq data from 17 public datasets. Weighted gene co-expression network analysis (WGCNA) was applied to identify gene modules associated with citrus species, tissue types, and days post-infection (DPIs). These modules revealed significant enrichment in biological pathways related to stress responses, metabolic reprograming, ribosomal protein synthesis, chloroplast and plastid function, cellular architecture, and intracellular transport. The results offer a molecular framework for understanding HLB pathogenesis and host response. By elucidating module-specific functions and their correlation with species- and tissue-specific responses, this study provides a robust foundation for identifying key genetic targets. These insights facilitate breeding programs focused on developing HLB-tolerant citrus cultivars, contributing to the long-term sustainability and resilience of global citrus production. EEA Concordia Fil: Machado, Rodrigo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concordia; Argentina. Fil: Moschen, Sebastian Nicolas. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Moschen, Sebastian Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Conti, Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Conti, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gonzalez, Sergio Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Rivarola, Maximo Lisandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Rivarola, Maximo Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gomez, Claudio Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concordia; Argentina Fil: Hopp, Horacio Esteban. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Fernandez, Paula Del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Fernandez, Paula Del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2025-06-13T11:22:15Z 2025-06-13T11:22:15Z 2025-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/22675 https://www.mdpi.com/2223-7747/14/12/1792 2223-7747 https://doi.org/10.3390/plants14121792 eng info:eu-repograntAgreement/INTA/2019-PD-E4-I101-001, Prospección, Prevención y Control de Lobesia botrana, Drosophila suzukii, HLB y Carpocapsa info:eu-repograntAgreement/INTA/2023-PD-L01-I106, Plagas y enfermedades emergentes, cuarentenarias y limitantes en cultivos frutícolas: estrategias para mejorar su prevención, detección precoz y control info:eu-repograntAgreement/INTA/2023-PE-L01-I051, Fortalecimiento y modernización de la cadena citrícola nacional con enfoque en la sostenibilidad en un marco de cambio climático info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Plants 14 (12) : 1792. (June 2025) |
| spellingShingle | Citrus Plant Diseases Huanglongbing Genetics Disease Tolerance Enfermedades de las Plantas Huanglongbing de los Cítricos Genética Tolerancia a Enfermedades HLB Candidatus Liberibacter Machado, Rodrigo Moschen, Sebastian Nicolas Conti, Gabriela Gonzalez, Sergio Alberto Rivarola, Maximo Lisandro Gomez, Claudio Andres Hopp, Horacio Esteban Fernandez, Paula Del Carmen Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues |
| title | Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues |
| title_full | Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues |
| title_fullStr | Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues |
| title_full_unstemmed | Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues |
| title_short | Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues |
| title_sort | exploring the genetic networks of hlb tolerance in citrus insights across species and tissues |
| topic | Citrus Plant Diseases Huanglongbing Genetics Disease Tolerance Enfermedades de las Plantas Huanglongbing de los Cítricos Genética Tolerancia a Enfermedades HLB Candidatus Liberibacter |
| url | http://hdl.handle.net/20.500.12123/22675 https://www.mdpi.com/2223-7747/14/12/1792 https://doi.org/10.3390/plants14121792 |
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