Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina
Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy...
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
Sage Publishing
2025
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/22577 https://journals.sagepub.com/doi/10.1177/10406387251336265 https://doi.org/10.1177/10406387251336265 |
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| author | Avellaneda Cáceres, Agustín Lee, Stephen T. Ruiz, Alvaro Francisco Sandoval, Gabriela Virginia Colque Caro, Luis Adrián Cook, Daniel Aguirre Castro, Laura Sabrina Uzal, Francisco A. Micheloud, Juan Francisco |
| author_browse | Aguirre Castro, Laura Sabrina Avellaneda Cáceres, Agustín Colque Caro, Luis Adrián Cook, Daniel Lee, Stephen T. Micheloud, Juan Francisco Ruiz, Alvaro Francisco Sandoval, Gabriela Virginia Uzal, Francisco A. |
| author_facet | Avellaneda Cáceres, Agustín Lee, Stephen T. Ruiz, Alvaro Francisco Sandoval, Gabriela Virginia Colque Caro, Luis Adrián Cook, Daniel Aguirre Castro, Laura Sabrina Uzal, Francisco A. Micheloud, Juan Francisco |
| author_sort | Avellaneda Cáceres, Agustín |
| collection | INTA Digital |
| description | Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future. |
| format | Artículo |
| id | INTA22577 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Sage Publishing |
| publisherStr | Sage Publishing |
| record_format | dspace |
| spelling | INTA225772025-06-09T11:45:59Z Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina Avellaneda Cáceres, Agustín Lee, Stephen T. Ruiz, Alvaro Francisco Sandoval, Gabriela Virginia Colque Caro, Luis Adrián Cook, Daniel Aguirre Castro, Laura Sabrina Uzal, Francisco A. Micheloud, Juan Francisco Panicum maximum Ganado Bovino Oxalatos Enfermedades Renales Plantas Tóxicas Argentina Cattle Oxalates Kidney Diseases Poisonous Plants Megathyrsus maximus Pasto Guinea Guinea Grass Nephropathy Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future. Instituto de Investigación Animal del Chaco Semiárido Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Avellaneda-Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina Fil: Avellaneda Cáceres, Agustín. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Cátedra Elementos de Reproducción y Sanidad Animal; Argentina Fil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos Fil: Lee, Stephen T. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos Fil: Ruiz, A.F. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina Fil: Sandoval, Gabriela V. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Sandoval, Gabriela V. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido; Argentina Fil: Sandoval, Gabriela V. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina Fil: Cook, Daniel. United States Departament of Agriculture. Poisonous Plant Research Laboratory; Estados Unidos Fil: Aguirre, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aguirre, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina Fil: Aguirre, Laura Sabrina. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina Fil: Uzal, Francisco A. University of California–Davis. California Animal Health and Food Safety Laboratory System; Estados Unidos Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal Chaco Semiárido; Argentina Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina 2025-06-09T11:40:20Z 2025-06-09T11:40:20Z 2025-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/22577 https://journals.sagepub.com/doi/10.1177/10406387251336265 1040-6387 1943-4936 https://doi.org/10.1177/10406387251336265 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Sage Publishing Journal of Veterinary Diagnostic Investigation : 1-4 (First published online May 19, 2025) |
| spellingShingle | Panicum maximum Ganado Bovino Oxalatos Enfermedades Renales Plantas Tóxicas Argentina Cattle Oxalates Kidney Diseases Poisonous Plants Megathyrsus maximus Pasto Guinea Guinea Grass Nephropathy Avellaneda Cáceres, Agustín Lee, Stephen T. Ruiz, Alvaro Francisco Sandoval, Gabriela Virginia Colque Caro, Luis Adrián Cook, Daniel Aguirre Castro, Laura Sabrina Uzal, Francisco A. Micheloud, Juan Francisco Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina |
| title | Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina |
| title_full | Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina |
| title_fullStr | Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina |
| title_full_unstemmed | Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina |
| title_short | Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina |
| title_sort | oxalate nephropathy in cattle associated with the consumption of megathyrsus maximus in argentina |
| topic | Panicum maximum Ganado Bovino Oxalatos Enfermedades Renales Plantas Tóxicas Argentina Cattle Oxalates Kidney Diseases Poisonous Plants Megathyrsus maximus Pasto Guinea Guinea Grass Nephropathy |
| url | http://hdl.handle.net/20.500.12123/22577 https://journals.sagepub.com/doi/10.1177/10406387251336265 https://doi.org/10.1177/10406387251336265 |
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