Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation
Pyrrolizidine alkaloidosis occurs sporadically in cattle in South America, associated with the consumption of several Senecio species including S. brasiliensis, S. grisebachii, S. madagascariensis, S. oxyphyllus and S. selloi. Although S. pampeanus has been potentially reported as hepatotoxic, there...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Springer
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/22449 https://link.springer.com/article/10.1007/s11259-025-10768-y https://doi.org/10.1007/s11259-025-10768-y |
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| author | Ovelar, María Florencia Garcia, Juan Agustin Cook, Daniel Gardner, Dale Stegelmeier, Bryan Diez De Ulzurrum, Patricia Tettamanti, Agustina Balbuena, Delfina Vilatuña Lita, Elvis Poo, Juan Ignacio Scioli, Maria Valeria Canton, German Jose |
| author_browse | Balbuena, Delfina Canton, German Jose Cook, Daniel Diez De Ulzurrum, Patricia Garcia, Juan Agustin Gardner, Dale Ovelar, María Florencia Poo, Juan Ignacio Scioli, Maria Valeria Stegelmeier, Bryan Tettamanti, Agustina Vilatuña Lita, Elvis |
| author_facet | Ovelar, María Florencia Garcia, Juan Agustin Cook, Daniel Gardner, Dale Stegelmeier, Bryan Diez De Ulzurrum, Patricia Tettamanti, Agustina Balbuena, Delfina Vilatuña Lita, Elvis Poo, Juan Ignacio Scioli, Maria Valeria Canton, German Jose |
| author_sort | Ovelar, María Florencia |
| collection | INTA Digital |
| description | Pyrrolizidine alkaloidosis occurs sporadically in cattle in South America, associated with the consumption of several Senecio species including S. brasiliensis, S. grisebachii, S. madagascariensis, S. oxyphyllus and S. selloi. Although S. pampeanus has been potentially reported as hepatotoxic, there is no scientific evidence of outbreaks associated with its consumption. This report describes a case of chronic hepatotoxicity in a beef heifer in Buenos Aires province in Argentina, grazing native grasslands heavily infested with S. pampeanus. Clinical and pathological findings were consistent with pyrrolizidine alkaloidosis, including hepatic fibrosis, marked hyperplasia of the bile ducts and the presence of abundant hepatomegalocytes. Furthermore, four unsaturated pyrrolizidine alkaloids (PAs) were identified in S. pampeanus including florosenine, doronine, otosenine and desacetyldoronine. Some clinical and histological details are suggestive of a chronic, low-dose pyrrolizidine alkaloidosis probably associated with the low concentration of toxic principles found in S. pampeanus. Further studies are needed to know PAs variation in S. pampeanus and its potential dissemination throughout the region, implying an important risk for livestock. |
| format | Artículo |
| id | INTA22449 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | INTA224492025-05-27T09:54:46Z Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation Ovelar, María Florencia Garcia, Juan Agustin Cook, Daniel Gardner, Dale Stegelmeier, Bryan Diez De Ulzurrum, Patricia Tettamanti, Agustina Balbuena, Delfina Vilatuña Lita, Elvis Poo, Juan Ignacio Scioli, Maria Valeria Canton, German Jose Ganado Bovino Alcaloide de Pirrolizidina Toxicología Plantas Tóxicas Cattle Senecio Pyrrolizidine Alkaloids Toxicology Poisonous Plants Pyrrolizidine alkaloidosis occurs sporadically in cattle in South America, associated with the consumption of several Senecio species including S. brasiliensis, S. grisebachii, S. madagascariensis, S. oxyphyllus and S. selloi. Although S. pampeanus has been potentially reported as hepatotoxic, there is no scientific evidence of outbreaks associated with its consumption. This report describes a case of chronic hepatotoxicity in a beef heifer in Buenos Aires province in Argentina, grazing native grasslands heavily infested with S. pampeanus. Clinical and pathological findings were consistent with pyrrolizidine alkaloidosis, including hepatic fibrosis, marked hyperplasia of the bile ducts and the presence of abundant hepatomegalocytes. Furthermore, four unsaturated pyrrolizidine alkaloids (PAs) were identified in S. pampeanus including florosenine, doronine, otosenine and desacetyldoronine. Some clinical and histological details are suggestive of a chronic, low-dose pyrrolizidine alkaloidosis probably associated with the low concentration of toxic principles found in S. pampeanus. Further studies are needed to know PAs variation in S. pampeanus and its potential dissemination throughout the region, implying an important risk for livestock. EEA Balcarce Fil: Ovelar, María Florencia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: García, Juan Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Cook, Daniel. Department of Agriculture, Poisonous Plant Research Laboratory; Estados Unidos Fil: Gardner, Dale. Department of Agriculture, Poisonous Plant Research Laboratory; Estados Unidos Fil: Stegelmeier, Bryan. Department of Agriculture, Poisonous Plant Research Laboratory; Estados Unidos Fil: Diez de Ulzurrun, Patricia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina Fil: Tettamanti, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Balbuena, Delfina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Vilatuña Lita, Elvis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Poo, Juan Ignacio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Scioli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina 2025-05-27T09:46:14Z 2025-05-27T09:46:14Z 2025-05-20 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/22449 https://link.springer.com/article/10.1007/s11259-025-10768-y 1573-7446 (Online) 0165-7380 (Print) https://doi.org/10.1007/s11259-025-10768-y eng info:eu-repograntAgreement/INTA/2019-RIST-E5-I111-001, Laboratorios de Diagnóstico Veterinario info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Springer Veterinary Research Communications 49 : 205. (May 2025) |
| spellingShingle | Ganado Bovino Alcaloide de Pirrolizidina Toxicología Plantas Tóxicas Cattle Senecio Pyrrolizidine Alkaloids Toxicology Poisonous Plants Ovelar, María Florencia Garcia, Juan Agustin Cook, Daniel Gardner, Dale Stegelmeier, Bryan Diez De Ulzurrum, Patricia Tettamanti, Agustina Balbuena, Delfina Vilatuña Lita, Elvis Poo, Juan Ignacio Scioli, Maria Valeria Canton, German Jose Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation |
| title | Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation |
| title_full | Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation |
| title_fullStr | Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation |
| title_full_unstemmed | Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation |
| title_short | Senecio pampeanus poisoning in beef cattle: case report and toxicological evaluation |
| title_sort | senecio pampeanus poisoning in beef cattle case report and toxicological evaluation |
| topic | Ganado Bovino Alcaloide de Pirrolizidina Toxicología Plantas Tóxicas Cattle Senecio Pyrrolizidine Alkaloids Toxicology Poisonous Plants |
| url | http://hdl.handle.net/20.500.12123/22449 https://link.springer.com/article/10.1007/s11259-025-10768-y https://doi.org/10.1007/s11259-025-10768-y |
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