Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells

Bovine campylobacteriosis is a distributed worldwide disease caused by Campylobacter fetus. It is a sexual transmitted disease that affects reproductive health in cattle. The objective of this study was to use bovine oviduct primary cell cultures as a pathogenicity model to study the virulence of Ca...

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Autores principales: Cagnoli, Claudia Inés, Chiapparrone, María Laura, Acuña, Francisco, Cacciato, Claudio Santiago, Rodríguez, Marcelo Gastón, Aller Atucha, Juan Florencio, Catena, María del Carmen
Formato: info:ar-repo/semantics/artículo
Lenguaje:Inglés
Publicado: Elsevier 2025
Materias:
Acceso en línea:http://hdl.handle.net/20.500.12123/22116
https://www.sciencedirect.com/science/article/abs/pii/S0882401025001548
https://doi.org/10.1016/j.micpath.2025.107429
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author Cagnoli, Claudia Inés
Chiapparrone, María Laura
Acuña, Francisco
Cacciato, Claudio Santiago
Rodríguez, Marcelo Gastón
Aller Atucha, Juan Florencio
Catena, María del Carmen
author_browse Acuña, Francisco
Aller Atucha, Juan Florencio
Cacciato, Claudio Santiago
Cagnoli, Claudia Inés
Catena, María del Carmen
Chiapparrone, María Laura
Rodríguez, Marcelo Gastón
author_facet Cagnoli, Claudia Inés
Chiapparrone, María Laura
Acuña, Francisco
Cacciato, Claudio Santiago
Rodríguez, Marcelo Gastón
Aller Atucha, Juan Florencio
Catena, María del Carmen
author_sort Cagnoli, Claudia Inés
collection INTA Digital
description Bovine campylobacteriosis is a distributed worldwide disease caused by Campylobacter fetus. It is a sexual transmitted disease that affects reproductive health in cattle. The objective of this study was to use bovine oviduct primary cell cultures as a pathogenicity model to study the virulence of Campylobacter fetus fetus and Campylobacter fetus venerealis. Both subspecies showed the ability to adhere to, invade and cause cytopathogenic effect in oviductal cells. Transmission electron microscopy revealed significant ultrastructural damage, including cytoplasmic vacuolization, nuclear condensation and mitochondrial alterations. These mitochondrial changes, such enlargement and fragmentation, suggest potential impacts on cell viability and host cellular metabolism. This study is the first to investigate the pathogenicity of both subspecies in primary bovine oviductal epithelial cells. These findings demonstrate the virulence mechanism of C. fetus in the reproductive tract, providing insights into oviductal pathogenicity and potential impacts on bovine fertility.
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publishDate 2025
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spelling INTA221162025-04-30T10:58:31Z Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells Cagnoli, Claudia Inés Chiapparrone, María Laura Acuña, Francisco Cacciato, Claudio Santiago Rodríguez, Marcelo Gastón Aller Atucha, Juan Florencio Catena, María del Carmen Ganado Bovino Enfermedades de los Animales Campilobacteriosis Cattle Campylobacter fetus Animal Diseases Campylobacteriosis Animal Reproduction Reproducción Animal Bovine campylobacteriosis is a distributed worldwide disease caused by Campylobacter fetus. It is a sexual transmitted disease that affects reproductive health in cattle. The objective of this study was to use bovine oviduct primary cell cultures as a pathogenicity model to study the virulence of Campylobacter fetus fetus and Campylobacter fetus venerealis. Both subspecies showed the ability to adhere to, invade and cause cytopathogenic effect in oviductal cells. Transmission electron microscopy revealed significant ultrastructural damage, including cytoplasmic vacuolization, nuclear condensation and mitochondrial alterations. These mitochondrial changes, such enlargement and fragmentation, suggest potential impacts on cell viability and host cellular metabolism. This study is the first to investigate the pathogenicity of both subspecies in primary bovine oviductal epithelial cells. These findings demonstrate the virulence mechanism of C. fetus in the reproductive tract, providing insights into oviductal pathogenicity and potential impacts on bovine fertility. EEA Balcarce Fil: Cagnoli, Claudia Inés. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Cagnoli, Claudia Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Cagnoli, Claudia Inés. Provincia de Buenos Aires. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Chiapparrone, María Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Chiapparrone, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Chiapparrone, María Laura. Provincia de Buenos Aires. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada; Argentina Fil: Cacciato, Claudio Santiago. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Cacciato, Claudio Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Cacciato, Claudio Santiago. Provincia de Buenos Aires. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Rodríguez, Marcelo Gastón. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Bioestadística; Argentina Fil: Aller Atucha, Juan Florencio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Catena, María del Carmen. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Catena, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina Fil: Catena, María del Carmen. Provincia de Buenos Aires. Comisión de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Microbiología Clínica y Experimental; Argentina 2025-04-30T10:54:49Z 2025-04-30T10:54:49Z 2025-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/22116 https://www.sciencedirect.com/science/article/abs/pii/S0882401025001548 0882-4010 1096-1208 https://doi.org/10.1016/j.micpath.2025.107429 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Microbial Pathogenesis 202 : 107429. (May 2025)
spellingShingle Ganado Bovino
Enfermedades de los Animales
Campilobacteriosis
Cattle
Campylobacter fetus
Animal Diseases
Campylobacteriosis
Animal Reproduction
Reproducción Animal
Cagnoli, Claudia Inés
Chiapparrone, María Laura
Acuña, Francisco
Cacciato, Claudio Santiago
Rodríguez, Marcelo Gastón
Aller Atucha, Juan Florencio
Catena, María del Carmen
Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells
title Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells
title_full Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells
title_fullStr Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells
title_full_unstemmed Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells
title_short Characterization of Campylobacter fetus adherence, invasiveness, and ultrastructural damage on bovine oviductal cells
title_sort characterization of campylobacter fetus adherence invasiveness and ultrastructural damage on bovine oviductal cells
topic Ganado Bovino
Enfermedades de los Animales
Campilobacteriosis
Cattle
Campylobacter fetus
Animal Diseases
Campylobacteriosis
Animal Reproduction
Reproducción Animal
url http://hdl.handle.net/20.500.12123/22116
https://www.sciencedirect.com/science/article/abs/pii/S0882401025001548
https://doi.org/10.1016/j.micpath.2025.107429
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