Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization
Bovine tuberculosis is a chronic disease caused by Mycobacterium bovis which rarely causes a neurologic clinical presentation. Tuberculous meningitis is a common clinical finding in young calves in dairy herds where tuberculosis is endemic, associated with the early consumption of milk from infected...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Springer
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/22088 https://link.springer.com/article/10.1007/s11259-025-10696-x https://doi.org/10.1007/s11259-025-10696-x |
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| author | Canton, German Jose Marron, Yolanda Fiorentino, María Andrea Morrell, Eleonora Lidia Garcia, Juan Agustin Marfil, María Urtizbiria, Facundo Nahuel Morsella, Claudia Graciela Cirone, Karina Mariela Scioli, Maria Valeria Zumarraga, Martin Jose Paolicchi, Fernando |
| author_browse | Canton, German Jose Cirone, Karina Mariela Fiorentino, María Andrea Garcia, Juan Agustin Marfil, María Marron, Yolanda Morrell, Eleonora Lidia Morsella, Claudia Graciela Paolicchi, Fernando Scioli, Maria Valeria Urtizbiria, Facundo Nahuel Zumarraga, Martin Jose |
| author_facet | Canton, German Jose Marron, Yolanda Fiorentino, María Andrea Morrell, Eleonora Lidia Garcia, Juan Agustin Marfil, María Urtizbiria, Facundo Nahuel Morsella, Claudia Graciela Cirone, Karina Mariela Scioli, Maria Valeria Zumarraga, Martin Jose Paolicchi, Fernando |
| author_sort | Canton, German Jose |
| collection | INTA Digital |
| description | Bovine tuberculosis is a chronic disease caused by Mycobacterium bovis which rarely causes a neurologic clinical presentation. Tuberculous meningitis is a common clinical finding in young calves in dairy herds where tuberculosis is endemic, associated with the early consumption of milk from infected cows. We report two simultaneous cases of vestibular syndrome, including loss of balance, circling, tilted head, and strabismus in 12- and 16-month-old Holstein heifers on a dairy farm in Tandil, Buenos Aires province, Argentina, with low tuberculosis prevalence (< 1.0%). Several widespread granulomatous lesions including large intracranial granulomas, characterized by a fibrous capsule containing pale yellow granular caseous material, with were observed during postmortem examination of both heifers. Microscopically, granulomas were characterized by the presence of a central caseous necrosis with mineralization, surrounded by an abundant macrophages, lymphocytes, and plasma cells infiltrate, with the presence of multiple Langhans-type giant cells, epithelioid macrophages, and connective tissue proliferation in the outer circumference. Mycobacterium bovis was isolated from different granulomas and associated lymph nodes and was typed by spoligotyping. This uncommon clinical presentation of bovine tuberculosis should be considered by veterinary practitioners, particularly in dairy herds where tuberculosis is endemic. |
| format | info:ar-repo/semantics/artículo |
| id | INTA22088 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | INTA220882025-04-29T10:38:32Z Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization Canton, German Jose Marron, Yolanda Fiorentino, María Andrea Morrell, Eleonora Lidia Garcia, Juan Agustin Marfil, María Urtizbiria, Facundo Nahuel Morsella, Claudia Graciela Cirone, Karina Mariela Scioli, Maria Valeria Zumarraga, Martin Jose Paolicchi, Fernando Novilla Mycobacterium bovis Tuberculosis Bovina Enfermedades de los Animales Ganado de Leche Heifers Bovine Tuberculosis Dairy Cattle Animal Diseases Bovine tuberculosis is a chronic disease caused by Mycobacterium bovis which rarely causes a neurologic clinical presentation. Tuberculous meningitis is a common clinical finding in young calves in dairy herds where tuberculosis is endemic, associated with the early consumption of milk from infected cows. We report two simultaneous cases of vestibular syndrome, including loss of balance, circling, tilted head, and strabismus in 12- and 16-month-old Holstein heifers on a dairy farm in Tandil, Buenos Aires province, Argentina, with low tuberculosis prevalence (< 1.0%). Several widespread granulomatous lesions including large intracranial granulomas, characterized by a fibrous capsule containing pale yellow granular caseous material, with were observed during postmortem examination of both heifers. Microscopically, granulomas were characterized by the presence of a central caseous necrosis with mineralization, surrounded by an abundant macrophages, lymphocytes, and plasma cells infiltrate, with the presence of multiple Langhans-type giant cells, epithelioid macrophages, and connective tissue proliferation in the outer circumference. Mycobacterium bovis was isolated from different granulomas and associated lymph nodes and was typed by spoligotyping. This uncommon clinical presentation of bovine tuberculosis should be considered by veterinary practitioners, particularly in dairy herds where tuberculosis is endemic. EEA Balcarce Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Marron, Yolanda. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Fiorentino, María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Morrell, Eleonora. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: García, Juan Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Marfil, María. Michigan State University. College of Veterinary Medicine; Estados Unidos Fil: Urtizbiria, Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Morsella, Claudia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Cirone, Karina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Scioli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Zumárraga, Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Paolicchi, Fernando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina 2025-04-29T10:25:30Z 2025-04-29T10:25:30Z 2025-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/22088 https://link.springer.com/article/10.1007/s11259-025-10696-x 1573-7446 (Online) 0165-7380 (Print) https://doi.org/10.1007/s11259-025-10696-x eng info:eu-repograntAgreement/INTA/2019-RIST-E5-I111-001, Laboratorios de Diagnóstico Veterinario info:eu-repograntAgreement/INTA/2019-PD-E5-I103-001, Desarrollo de tecnologías diagnósticas y estudios epidemiológicos para el control de enfermedades que afectan la producción animal y la salud pública info:eu-repograntAgreement/INTA/2023-PD-L06-I114, Desarrollo y aplicación de métodos diagnósticos y epidemiológicos para la producción pecuaria sustentable y agroalimentaria en humanos con foco en Una Salud info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Springer Veterinary Research Communications 49 : 124 (03 March 2025) |
| spellingShingle | Novilla Mycobacterium bovis Tuberculosis Bovina Enfermedades de los Animales Ganado de Leche Heifers Bovine Tuberculosis Dairy Cattle Animal Diseases Canton, German Jose Marron, Yolanda Fiorentino, María Andrea Morrell, Eleonora Lidia Garcia, Juan Agustin Marfil, María Urtizbiria, Facundo Nahuel Morsella, Claudia Graciela Cirone, Karina Mariela Scioli, Maria Valeria Zumarraga, Martin Jose Paolicchi, Fernando Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization |
| title | Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization |
| title_full | Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization |
| title_fullStr | Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization |
| title_full_unstemmed | Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization |
| title_short | Vestibular syndrome in dairy heifers associated with Mycobacterium bovis: two case reports and strain characterization |
| title_sort | vestibular syndrome in dairy heifers associated with mycobacterium bovis two case reports and strain characterization |
| topic | Novilla Mycobacterium bovis Tuberculosis Bovina Enfermedades de los Animales Ganado de Leche Heifers Bovine Tuberculosis Dairy Cattle Animal Diseases |
| url | http://hdl.handle.net/20.500.12123/22088 https://link.springer.com/article/10.1007/s11259-025-10696-x https://doi.org/10.1007/s11259-025-10696-x |
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