Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis
Rotavirus alphagastroenteritidis is the major causative agent of acute gastroenteritis in both children under the age of 5 and young mammals and birds globally. RVAs are non-enveloped viruses with a genome comprising 11 double-stranded RNA segments. In 2008, the Rotavirus Classification Working Grou...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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MDPI
2025
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| Online Access: | http://hdl.handle.net/20.500.12123/21512 https://www.mdpi.com/1999-4915/17/2/211 https://doi.org/10.3390/v17020211 |
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| author | Díaz Alarcón, Ricardo Gabriel Salvatierra, Karina Gómez Quintero, Emiliano Liotta, Domingo Javier Parreño, Gladys Viviana Miño, Samuel |
| author_browse | Díaz Alarcón, Ricardo Gabriel Gómez Quintero, Emiliano Liotta, Domingo Javier Miño, Samuel Parreño, Gladys Viviana Salvatierra, Karina |
| author_facet | Díaz Alarcón, Ricardo Gabriel Salvatierra, Karina Gómez Quintero, Emiliano Liotta, Domingo Javier Parreño, Gladys Viviana Miño, Samuel |
| author_sort | Díaz Alarcón, Ricardo Gabriel |
| collection | INTA Digital |
| description | Rotavirus alphagastroenteritidis is the major causative agent of acute gastroenteritis in both children under the age of 5 and young mammals and birds globally. RVAs are non-enveloped viruses with a genome comprising 11 double-stranded RNA segments. In 2008, the Rotavirus Classification Working Group pioneered a comprehensive and complete RVA genome classification system, establishing a specific threshold, which measures the genetic distances between homologous genes. The aim of this study was to perform an updated systematic analysis of the genetic variability across all RVA genes. Our investigation involved assessing the established cutoff values for each RVA genome segment and determining the need for any updates. To achieve this objective, multiple sequence alignments were constructed for all 11 genes and one for each genotype with discrepancies. Also, pairwise distances along with their cutoff values were evaluated. The analyses provided insights into the current relevance of cutoff values, which remain applicable for the majority of genotypes. In conclusion, this study fortifies the current classification system by highlighting its robustness and accurate genotyping of Rotavirus alphagastroenteritidis. |
| format | info:ar-repo/semantics/artículo |
| id | INTA21512 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA215122025-02-28T13:20:29Z Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis Díaz Alarcón, Ricardo Gabriel Salvatierra, Karina Gómez Quintero, Emiliano Liotta, Domingo Javier Parreño, Gladys Viviana Miño, Samuel Phylogeny Genomes Rotavirus Gastroenteritis Genetic Variation Filogenia Genoma Variación Genética Rotavirus alphagastroenteritidis Rotavirus alphagastroenteritidis is the major causative agent of acute gastroenteritis in both children under the age of 5 and young mammals and birds globally. RVAs are non-enveloped viruses with a genome comprising 11 double-stranded RNA segments. In 2008, the Rotavirus Classification Working Group pioneered a comprehensive and complete RVA genome classification system, establishing a specific threshold, which measures the genetic distances between homologous genes. The aim of this study was to perform an updated systematic analysis of the genetic variability across all RVA genes. Our investigation involved assessing the established cutoff values for each RVA genome segment and determining the need for any updates. To achieve this objective, multiple sequence alignments were constructed for all 11 genes and one for each genotype with discrepancies. Also, pairwise distances along with their cutoff values were evaluated. The analyses provided insights into the current relevance of cutoff values, which remain applicable for the majority of genotypes. In conclusion, this study fortifies the current classification system by highlighting its robustness and accurate genotyping of Rotavirus alphagastroenteritidis. Instituto de Virología Fil: Díaz Alarcón, Ricardo G. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina Fil: Díaz Alarcón, Ricardo G. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Salvatierra, Karina. Universidad Nacional de Misiones. Laboratorio “MADAR”; Argentina Fil: Gómez Quintero, Emiliano. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina Fil: Liotta, Domingo Javier. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina Fil: Liotta, Domingo Javier. Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) “Dr. Carlos Malbrán”. Instituto Nacional de Medicina Tropical; Argentina Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). INCUINTA. Instituto de Virologia e Innovaciones Tecnologicas (IVIT); Argentina Fil: Miño, Samuel. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina Fil: Miño, Samuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Cerro Azul; Argentina 2025-02-28T13:05:37Z 2025-02-28T13:05:37Z 2025-02 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/21512 https://www.mdpi.com/1999-4915/17/2/211 1999-4915 https://doi.org/10.3390/v17020211 eng info:eu-repograntAgreement/INTA/2023-PE-L01-I044, Enfermedades subtropicales con impacto sobre la producción, salud pública y sustentabilidad en la ganadería del norte de Argentina info:eu-repograntAgreement/INTA/2019-RIST-E5-I111-001, Laboratorios de Diagnóstico Veterinario info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 17 (2) : 211 (February 2025) |
| spellingShingle | Phylogeny Genomes Rotavirus Gastroenteritis Genetic Variation Filogenia Genoma Variación Genética Rotavirus alphagastroenteritidis Díaz Alarcón, Ricardo Gabriel Salvatierra, Karina Gómez Quintero, Emiliano Liotta, Domingo Javier Parreño, Gladys Viviana Miño, Samuel Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis |
| title | Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis |
| title_full | Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis |
| title_fullStr | Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis |
| title_full_unstemmed | Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis |
| title_short | Complete genome classification system of rotavirus alphagastroenteritidis : An updated analysis |
| title_sort | complete genome classification system of rotavirus alphagastroenteritidis an updated analysis |
| topic | Phylogeny Genomes Rotavirus Gastroenteritis Genetic Variation Filogenia Genoma Variación Genética Rotavirus alphagastroenteritidis |
| url | http://hdl.handle.net/20.500.12123/21512 https://www.mdpi.com/1999-4915/17/2/211 https://doi.org/10.3390/v17020211 |
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