Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin
The aim of this work was to analyse the spatiotemporal heterogeneity of Rhipicephalus microplus (Canestrini, 1888) (Acari: Ixodidae) resistance to chemical acaricides at intra-farm level under different environmental (favourable and unfavourable areas for tick development) and management (different...
| Autores principales: | , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Royal Entomological Society
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/21059 https://resjournals.onlinelibrary.wiley.com/doi/10.1111/mve.12783 https://doi.org/10.1111/mve.12783 |
| _version_ | 1855038336406650880 |
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| author | Morel, Nicolas Torrents, Jorgelina Sarli, Macarena Rossner, Maria Victoria Lifschitz, Adrian Luis Nava, Santiago |
| author_browse | Lifschitz, Adrian Luis Morel, Nicolas Nava, Santiago Rossner, Maria Victoria Sarli, Macarena Torrents, Jorgelina |
| author_facet | Morel, Nicolas Torrents, Jorgelina Sarli, Macarena Rossner, Maria Victoria Lifschitz, Adrian Luis Nava, Santiago |
| author_sort | Morel, Nicolas |
| collection | INTA Digital |
| description | The aim of this work was to analyse the spatiotemporal heterogeneity of Rhipicephalus microplus (Canestrini, 1888) (Acari: Ixodidae) resistance to chemical acaricides at intra-farm level under different environmental (favourable and unfavourable areas for tick development) and management (different schemes of acaricides applications) conditions using ivermectin as a model. The in vitro larval immersion test (LIT) was used to determine quantitatively the levels of resistance to ivermectin in the different populations and subpopulations of R. microplus analysed. In the first case study, differences in resistance levels among tick samples within the same paddock across time and among tick samples from different paddocks were recorded. These results stress the importance of taking successive samples so that they represent the spatial and temporal variabilities in the levels of resistance that can occur within the same farm. In a second case study, the evolution of resistance in R. microplus subpopulations subjected to strategic and threshold control methods based on the application of three annual treatments with alternation of chemical groups was compared. No changes in resistance/susceptibility status were observed in both tick subpopulations. These results show that the application of a particular drug once a year within a scheme of alternation with other chemical groups could be an appropriate strategy to delay the development of resistance. Data of the third case study showed that environmental constraints is not only a key modulator of R. microplus abundance but could also affect the evolution of resistance in the tick populations. The decreasing trend of LC50 values in the tick subpopulation not exposed to chemical treatments but also in that subpopulation exposed to three annual chemical treatments under unfavourable environmental conditions allow us to hypothesise that environmental constraints can modify the levels of resistance in a tick population because it can constitute a stronger selection factor than the treatments themselves. |
| format | info:ar-repo/semantics/artículo |
| id | INTA21059 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Royal Entomological Society |
| publisherStr | Royal Entomological Society |
| record_format | dspace |
| spelling | INTA210592025-02-13T16:14:41Z Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin Morel, Nicolas Torrents, Jorgelina Sarli, Macarena Rossner, Maria Victoria Lifschitz, Adrian Luis Nava, Santiago Ganado Bovino Control de Enfermedades Resistencia a Productos Químicos Garrapatas Cattle Disease Control Resistance to Chemicals Ticks The aim of this work was to analyse the spatiotemporal heterogeneity of Rhipicephalus microplus (Canestrini, 1888) (Acari: Ixodidae) resistance to chemical acaricides at intra-farm level under different environmental (favourable and unfavourable areas for tick development) and management (different schemes of acaricides applications) conditions using ivermectin as a model. The in vitro larval immersion test (LIT) was used to determine quantitatively the levels of resistance to ivermectin in the different populations and subpopulations of R. microplus analysed. In the first case study, differences in resistance levels among tick samples within the same paddock across time and among tick samples from different paddocks were recorded. These results stress the importance of taking successive samples so that they represent the spatial and temporal variabilities in the levels of resistance that can occur within the same farm. In a second case study, the evolution of resistance in R. microplus subpopulations subjected to strategic and threshold control methods based on the application of three annual treatments with alternation of chemical groups was compared. No changes in resistance/susceptibility status were observed in both tick subpopulations. These results show that the application of a particular drug once a year within a scheme of alternation with other chemical groups could be an appropriate strategy to delay the development of resistance. Data of the third case study showed that environmental constraints is not only a key modulator of R. microplus abundance but could also affect the evolution of resistance in the tick populations. The decreasing trend of LC50 values in the tick subpopulation not exposed to chemical treatments but also in that subpopulation exposed to three annual chemical treatments under unfavourable environmental conditions allow us to hypothesise that environmental constraints can modify the levels of resistance in a tick population because it can constitute a stronger selection factor than the treatments themselves. Instituto Nacional de Tecnología Agropecuaria (INTA), Asociación Cooperadora INTA Rafaela y Secretaría de Innovación, Ciencia y Tecnología (Proyectos de Redes Federales de Alto Impacto: REDGARR 100390265) EEA Rafaela Fil: Morel, Nicolas. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina Fil: Morel, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina Fil: Torrents, Jorgelina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina Fil: Torrents, Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina Fil: Torrents, Jorgelina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina Fil: Sarli, Macarena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina Fil: Sarli, Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina Fil: Rossner, Maria Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; Argentina Fil: Lifschitz, Adrian. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA). Facultad de Ciencias Veterinarias; Argentina Fil: Lifschitz, Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Lifschitz, Adrian. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA). Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina Fil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigación de la Cadena Láctea (IdICaL); Argentina 2025-01-24T12:43:51Z 2025-01-24T12:43:51Z 2024-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/21059 https://resjournals.onlinelibrary.wiley.com/doi/10.1111/mve.12783 1365-2915 (online) 0269-283X (print) https://doi.org/10.1111/mve.12783 eng info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Royal Entomological Society Medical and Veterinary Entomology : 1-10 (2024) |
| spellingShingle | Ganado Bovino Control de Enfermedades Resistencia a Productos Químicos Garrapatas Cattle Disease Control Resistance to Chemicals Ticks Morel, Nicolas Torrents, Jorgelina Sarli, Macarena Rossner, Maria Victoria Lifschitz, Adrian Luis Nava, Santiago Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin |
| title | Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin |
| title_full | Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin |
| title_fullStr | Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin |
| title_full_unstemmed | Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin |
| title_short | Spatiotemporal heterogeneity of Rhipicephalus microplus resistance to chemical acaricides at intra-farm level: A case study using ivermectin |
| title_sort | spatiotemporal heterogeneity of rhipicephalus microplus resistance to chemical acaricides at intra farm level a case study using ivermectin |
| topic | Ganado Bovino Control de Enfermedades Resistencia a Productos Químicos Garrapatas Cattle Disease Control Resistance to Chemicals Ticks |
| url | http://hdl.handle.net/20.500.12123/21059 https://resjournals.onlinelibrary.wiley.com/doi/10.1111/mve.12783 https://doi.org/10.1111/mve.12783 |
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