Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina)...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Nature Publishing Group
2024
|
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/20462 https://www.nature.com/articles/s41467-024-53766-5 https://doi.org/10.1038/s41467-024-53766-5 |
| _version_ | 1855486576411279360 |
|---|---|
| author | Uhart, Marcela M. Vanstreels, Ralph E. T. Nelson, Martha I. Olivera, Valeria Soledad Campagna, Julieta Zavattieri, Victoria Lemey, Philippe Campagna, Claudio Falabella, Valeria Rimondi, Agustina |
| author_browse | Campagna, Claudio Campagna, Julieta Falabella, Valeria Lemey, Philippe Nelson, Martha I. Olivera, Valeria Soledad Rimondi, Agustina Uhart, Marcela M. Vanstreels, Ralph E. T. Zavattieri, Victoria |
| author_facet | Uhart, Marcela M. Vanstreels, Ralph E. T. Nelson, Martha I. Olivera, Valeria Soledad Campagna, Julieta Zavattieri, Victoria Lemey, Philippe Campagna, Claudio Falabella, Valeria Rimondi, Agustina |
| author_sort | Uhart, Marcela M. |
| collection | INTA Digital |
| description | H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on H5N1 viruses in concurrently dead terns. Our genomic analysis shows that viruses from pinnipeds and terns in Argentina form a distinct clade with marine mammal viruses from Peru, Chile, Brazil and Uruguay. Additionally, these marine mammal clade viruses share an identical set of mammalian adaptation mutations which were also present in tern viruses. Our combined ecological and phylogenetic data support mammal-to-mammal transmission and occasional mammal-to-bird spillover and suggest multinational transmission of H5N1 viruses in mammals. We reflect that H5N1 viruses becoming more evolutionary flexible and adapting to mammals in new ways could have global consequences for wildlife, humans, and/or livestock. |
| format | Artículo |
| id | INTA20462 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Nature Publishing Group |
| publisherStr | Nature Publishing Group |
| record_format | dspace |
| spelling | INTA204622024-12-04T11:53:07Z Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission Uhart, Marcela M. Vanstreels, Ralph E. T. Nelson, Martha I. Olivera, Valeria Soledad Campagna, Julieta Zavattieri, Victoria Lemey, Philippe Campagna, Claudio Falabella, Valeria Rimondi, Agustina Influenzavirus Marine Mammals Pathogenicity Disease Outbreaks Mirounga leonina Mamífero Marino Patogenicidad Brote de Enfermedad Argentina Elephant Seals Elefante Marino H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on H5N1 viruses in concurrently dead terns. Our genomic analysis shows that viruses from pinnipeds and terns in Argentina form a distinct clade with marine mammal viruses from Peru, Chile, Brazil and Uruguay. Additionally, these marine mammal clade viruses share an identical set of mammalian adaptation mutations which were also present in tern viruses. Our combined ecological and phylogenetic data support mammal-to-mammal transmission and occasional mammal-to-bird spillover and suggest multinational transmission of H5N1 viruses in mammals. We reflect that H5N1 viruses becoming more evolutionary flexible and adapting to mammals in new ways could have global consequences for wildlife, humans, and/or livestock. Instituto de Virología Fil: Uhart, Marcela M. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados Unidos Fil: Uhart, Marcela M. Southern RightWhale Health Monitoring Program; Argentina Fil: Vanstreels, Ralph E. T. University of California Davis. School of Veterinary Medicine. Karen C. Drayer Wildlife Health Center; Estados Unidos Fil: Nelson, Martha I. National Institutes of Health. National Library of Medicine. National Center for Biotechnology Information; Estados Unidos Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Olivera, Valeria Soledad. Consejo Nacional de Investigaciones Científcas y Técnicas; Argentina Fil: Campagna, Julieta. Wildlife Conservation Society. Argentina Program; Argentina Fil: Zavattieri, Victoria. Wildlife Conservation Society. Argentina Program; Argentina Fil: Lemey, Philippe. Laboratory for Clinical and Epidemiological Virology. Rega Institute. Department of Microbiology, Immunology and Transplantation; Bélgica Fil: Campagna, Claudio. Wildlife Conservation Society. Argentina Program; Argentina Fil: Falabella, Valeria. Wildlife Conservation Society. Argentina Program; Argentina Fil: Rimondi, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Rimondi, Agustina. Consejo Nacional de Investigaciones Científcas y Técnicas; Argentina Fil: Rimondi, Agustina. Robert Koch Institute-Alexander von Humboldt fellowship; Alemania 2024-12-04T11:45:07Z 2024-12-04T11:45:07Z 2024-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/20462 https://www.nature.com/articles/s41467-024-53766-5 2041-1723 https://doi.org/10.1038/s41467-024-53766-5 eng info:eu-repograntAgreement/INTA/2023-PD-L06-I114, Desarrollo y aplicación de métodos diagnósticos y epidemiológicos para la producción pecuaria sustentable y agroalimentaria en humanos con foco en Una Salud info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Nature Publishing Group Nature Communications 15 : 9516 (Noviember 2024) |
| spellingShingle | Influenzavirus Marine Mammals Pathogenicity Disease Outbreaks Mirounga leonina Mamífero Marino Patogenicidad Brote de Enfermedad Argentina Elephant Seals Elefante Marino Uhart, Marcela M. Vanstreels, Ralph E. T. Nelson, Martha I. Olivera, Valeria Soledad Campagna, Julieta Zavattieri, Victoria Lemey, Philippe Campagna, Claudio Falabella, Valeria Rimondi, Agustina Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission |
| title | Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission |
| title_full | Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission |
| title_fullStr | Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission |
| title_full_unstemmed | Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission |
| title_short | Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission |
| title_sort | epidemiological data of an influenza a h5n1 outbreak in elephant seals in argentina indicates mammal to mammal transmission |
| topic | Influenzavirus Marine Mammals Pathogenicity Disease Outbreaks Mirounga leonina Mamífero Marino Patogenicidad Brote de Enfermedad Argentina Elephant Seals Elefante Marino |
| url | http://hdl.handle.net/20.500.12123/20462 https://www.nature.com/articles/s41467-024-53766-5 https://doi.org/10.1038/s41467-024-53766-5 |
| work_keys_str_mv | AT uhartmarcelam epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT vanstreelsralphet epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT nelsonmarthai epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT oliveravaleriasoledad epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT campagnajulieta epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT zavattierivictoria epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT lemeyphilippe epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT campagnaclaudio epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT falabellavaleria epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission AT rimondiagustina epidemiologicaldataofaninfluenzaah5n1outbreakinelephantsealsinargentinaindicatesmammaltomammaltransmission |