Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle
The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vacc...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2024
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/20461 https://www.mdpi.com/1999-4915/16/11/1732 https://doi.org/10.3390/v16111732 |
| _version_ | 1855486576221487104 |
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| author | Miraglia, Maria Cruz Barrios-Benito, Melanie Galdo Novo, Sabrina Bucafusco, Danilo Taffarel, Ana Capozzo, Alejandra Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author_browse | Barrios-Benito, Melanie Borca, Manuel Victor Bucafusco, Danilo Capozzo, Alejandra Galdo Novo, Sabrina Miraglia, Maria Cruz Perez Filgueira, Daniel Mariano Taffarel, Ana |
| author_facet | Miraglia, Maria Cruz Barrios-Benito, Melanie Galdo Novo, Sabrina Bucafusco, Danilo Taffarel, Ana Capozzo, Alejandra Borca, Manuel Victor Perez Filgueira, Daniel Mariano |
| author_sort | Miraglia, Maria Cruz |
| collection | INTA Digital |
| description | The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Naïve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern.
Keywords: foot-and-mouth disease; cattle; heterologous protection |
| format | Artículo |
| id | INTA20461 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA204612024-12-04T11:41:25Z Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle Miraglia, Maria Cruz Barrios-Benito, Melanie Galdo Novo, Sabrina Bucafusco, Danilo Taffarel, Ana Capozzo, Alejandra Borca, Manuel Victor Perez Filgueira, Daniel Mariano Foot-and-mouth Disease Cattle Immunization Neutralization Serotypes Fiebre Aftosa Ganado Bovino Inmunización Neutralización Serotipos The high antigenic variability of the foot-and-mouth disease virus (FMDV) represents a challenge for developing prophylactic strategies, stressing the need for research into vaccines offering broad protection against a range of virus strains. Here, the heterotypic cross-reaction using different vaccine schemes against serotype O strains was studied, evaluating the impact of revaccination, antigen dose, and incorporation of additional FMDV serotypes. Naïve cattle were immunized with seven distinct FMDV vaccines, receiving three doses of the same formulation at 0, 28, and 56 days post-primary vaccination (dpv). Serum samples were collected up to 70 dpv and tested by a virus-neutralizing test against serotype O strains from a South American lineage and two strains representative of two Asian lineages. Our results showed that vaccines containing the ME-SA topotype O1/Campos strain developed cross-neutralizing responses against the two Asian viruses after the first vaccination. In contrast, significant heterotypic neutralizing antibody titers against the homologous topotype strain were only found after the second vaccination, indicating that the phylogenic relationship may differ from the antigenic profiles for these two viruses. The amount of the O1/Campos strain and the revaccination were essential factors for neutralization against the homologous- and heterologous-type O FMDV viruses. The strain composition of the vaccine was only relevant for cross-neutralization against one of the Asian strains, suggesting potential intra-serotypic divergences for this pattern. Keywords: foot-and-mouth disease; cattle; heterologous protection Instituto de Virología Fil: Miraglia, Maria Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Miraglia, Maria Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Barrios-Benito, Melanie. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina Fil: Galdo Novo, Sabrina. Servicio Nacional de Sanidad y Calidad Agroalimentaria (SENASA); Argentina Fil: Bucafusco, Danilo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Virología; Argentina Fil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bucafusco, Danilo. Universidad de Buenos Aires. Instituto de Investigaciones en Producción Animal; Argentina Fil: Taffarel, Ana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Taffarel, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capozzo, Alejandra. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); Argentina Fil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Borca, Manuel Victor. USDA. Agricultural Research Service. Plum Island Animal Disease Center; Estados Unidos Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Perez Filgueira, Daniel Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2024-12-04T11:35:20Z 2024-12-04T11:35:20Z 2024-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/20461 https://www.mdpi.com/1999-4915/16/11/1732 1999-4915 https://doi.org/10.3390/v16111732 eng info:eu-repograntAgreement/INTA/2023-PD-L01-I113, Herramientas de estudio de la Patogenia e Inmunidad en agentes infecciosos y tóxicos que aporten a la sustentabilidad de la producción pecuaria en el marco de Una Salud info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 16 (11) : 1732 (November 2024) |
| spellingShingle | Foot-and-mouth Disease Cattle Immunization Neutralization Serotypes Fiebre Aftosa Ganado Bovino Inmunización Neutralización Serotipos Miraglia, Maria Cruz Barrios-Benito, Melanie Galdo Novo, Sabrina Bucafusco, Danilo Taffarel, Ana Capozzo, Alejandra Borca, Manuel Victor Perez Filgueira, Daniel Mariano Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle |
| title | Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle |
| title_full | Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle |
| title_fullStr | Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle |
| title_full_unstemmed | Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle |
| title_short | Impact of different foot and mouth disease vaccine schemes in cross-neutralization against heterologous serotype O strains in cattle |
| title_sort | impact of different foot and mouth disease vaccine schemes in cross neutralization against heterologous serotype o strains in cattle |
| topic | Foot-and-mouth Disease Cattle Immunization Neutralization Serotypes Fiebre Aftosa Ganado Bovino Inmunización Neutralización Serotipos |
| url | http://hdl.handle.net/20.500.12123/20461 https://www.mdpi.com/1999-4915/16/11/1732 https://doi.org/10.3390/v16111732 |
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