Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina
Western equine encephalitis virus (WEEV) is a mosquito-borne arbovirus (genus Alphavirus, family Togaviridae) that has re-emerged in South America in late 2023, causing severe disease in both horses and humans after a nearly 40-year intermission period. We here describe the virological, serological,...
| Autores principales: | , , , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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MDPI
2024
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/20308 https://www.mdpi.com/1999-4915/16/10/1594 https://doi.org/10.3390/v16101594 |
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| author | Vissani, Maria Aldana Alamos, Florencia Tordoya, Maria Silvia Minatel, Leonardo Schammas, Juan Manuel Dus Santos, Maria Jose Trono, Karina Gabriela Barrandeguy, Maria Edith Balasuriya, Udeni B.R. Carossino, Mariano |
| author_browse | Alamos, Florencia Balasuriya, Udeni B.R. Barrandeguy, Maria Edith Carossino, Mariano Dus Santos, Maria Jose Minatel, Leonardo Schammas, Juan Manuel Tordoya, Maria Silvia Trono, Karina Gabriela Vissani, Maria Aldana |
| author_facet | Vissani, Maria Aldana Alamos, Florencia Tordoya, Maria Silvia Minatel, Leonardo Schammas, Juan Manuel Dus Santos, Maria Jose Trono, Karina Gabriela Barrandeguy, Maria Edith Balasuriya, Udeni B.R. Carossino, Mariano |
| author_sort | Vissani, Maria Aldana |
| collection | INTA Digital |
| description | Western equine encephalitis virus (WEEV) is a mosquito-borne arbovirus (genus Alphavirus, family Togaviridae) that has re-emerged in South America in late 2023, causing severe disease in both horses and humans after a nearly 40-year intermission period. We here describe the virological, serological, pathological, and molecular features of WEEV infection in horses during the 2023–2024 outbreak in Argentina. WEEV-infected horses developed neurological signs with mild to severe encephalitis associated with minimal to abundant WEEV-infected cells, as demonstrated by WEEV-specific in situ hybridization. The distribution of viral RNA was multifocal, with predominance within neuronal bodies, neuronal processes, and glial cells in the medulla oblongata and thalamic regions. Phylogenetic analysis of partial nsP4 sequences from three viral isolates obtained from three different provinces of Argentina support grouping with other temporally current WEEV strains from Uruguay and Brazil under a recently proposed novel lineage. |
| format | info:ar-repo/semantics/artículo |
| id | INTA20308 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA203082024-11-15T14:51:06Z Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina Vissani, Maria Aldana Alamos, Florencia Tordoya, Maria Silvia Minatel, Leonardo Schammas, Juan Manuel Dus Santos, Maria Jose Trono, Karina Gabriela Barrandeguy, Maria Edith Balasuriya, Udeni B.R. Carossino, Mariano Western Equine Encephalomyelitis Encephalitis Horses Hybridization Nervous System Diseases Encefalomielitis Equina del Oeste Encefalitis Caballos Hibridación Trastornos del Sistema Nervioso Argentina In Situ Hybridization Outbreak Hibridación in Situ Brote Western equine encephalitis virus (WEEV) is a mosquito-borne arbovirus (genus Alphavirus, family Togaviridae) that has re-emerged in South America in late 2023, causing severe disease in both horses and humans after a nearly 40-year intermission period. We here describe the virological, serological, pathological, and molecular features of WEEV infection in horses during the 2023–2024 outbreak in Argentina. WEEV-infected horses developed neurological signs with mild to severe encephalitis associated with minimal to abundant WEEV-infected cells, as demonstrated by WEEV-specific in situ hybridization. The distribution of viral RNA was multifocal, with predominance within neuronal bodies, neuronal processes, and glial cells in the medulla oblongata and thalamic regions. Phylogenetic analysis of partial nsP4 sequences from three viral isolates obtained from three different provinces of Argentina support grouping with other temporally current WEEV strains from Uruguay and Brazil under a recently proposed novel lineage. Instituto de Virología Fil: Vissani, Maria Aldana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Vissani, Maria Aldana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Vissani, Maria Aldana. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinarias. Escuela de Veterinaria; Argentina Fil: Alamos, Florencia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Tordoya, Maria Silvia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Minatel, Leonardo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Dus Santos, María José. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Barrandeguy, Maria Edith. Instituto Nacional de Investigación Agropecuaria (INIA). Estación Experimental La Estanzuela. Plataforma de Investigación en Salud Animal; Uruguay Fil: Balasuriya, Udeni B. R. Louisiana State University. School of Veterinary Medicine. Department of Pathobiological Sciences; Estados Unidos Fil: Balasuriya, Udeni B. R. Louisiana State University. School of Veterinary Medicine. Louisiana Animal Disease Diagnostic Laboratory; Estados Unidos Fil: Carossino, Mariano. Louisiana State University. School of Veterinary Medicine. Department of Pathobiological Sciences; Estados Unidos Fil: Carossino, Mariano. Louisiana State University. School of Veterinary Medicine. Louisiana Animal Disease Diagnostic Laboratory; Estados Unidos 2024-11-15T14:44:02Z 2024-11-15T14:44:02Z 2024-10 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/20308 https://www.mdpi.com/1999-4915/16/10/1594 1999-4915 https://doi.org/10.3390/v16101594 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 16 (10) : 1594 (October 2024) |
| spellingShingle | Western Equine Encephalomyelitis Encephalitis Horses Hybridization Nervous System Diseases Encefalomielitis Equina del Oeste Encefalitis Caballos Hibridación Trastornos del Sistema Nervioso Argentina In Situ Hybridization Outbreak Hibridación in Situ Brote Vissani, Maria Aldana Alamos, Florencia Tordoya, Maria Silvia Minatel, Leonardo Schammas, Juan Manuel Dus Santos, Maria Jose Trono, Karina Gabriela Barrandeguy, Maria Edith Balasuriya, Udeni B.R. Carossino, Mariano Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina |
| title | Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina |
| title_full | Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina |
| title_fullStr | Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina |
| title_full_unstemmed | Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina |
| title_short | Outbreak of Western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40-year intermission period in Argentina |
| title_sort | outbreak of western equine encephalitis virus infection associated with neurological disease in horses following a nearly 40 year intermission period in argentina |
| topic | Western Equine Encephalomyelitis Encephalitis Horses Hybridization Nervous System Diseases Encefalomielitis Equina del Oeste Encefalitis Caballos Hibridación Trastornos del Sistema Nervioso Argentina In Situ Hybridization Outbreak Hibridación in Situ Brote |
| url | http://hdl.handle.net/20.500.12123/20308 https://www.mdpi.com/1999-4915/16/10/1594 https://doi.org/10.3390/v16101594 |
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