Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology
Historically, botanical preparations have been used to improve human health. Their active ingredients are influenced by multiple factors such as intraspecies variations, environmental conditions, collection time and methods, and the part of the plant used. To ensure the efficiency and safety of thes...
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| Format: | Artículo |
| Language: | Inglés |
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MDPI
2024
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| Online Access: | http://hdl.handle.net/20.500.12123/20297 https://www.mdpi.com/2223-7747/13/21/3062 https://doi.org/10.3390/plants13213062 |
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| author | Pascual, Lourdes Inés Luna, Lorena Celina Gonzalez, Roxana Elizabeth Ortiz, Javier Esteban Gomez Gomez, Luciano Donadel, Osvaldo Juan Hapon, María Belén Feresin, Gabriela Egly Gamarra Luques, Carlos Diego |
| author_browse | Donadel, Osvaldo Juan Feresin, Gabriela Egly Gamarra Luques, Carlos Diego Gomez Gomez, Luciano Gonzalez, Roxana Elizabeth Hapon, María Belén Luna, Lorena Celina Ortiz, Javier Esteban Pascual, Lourdes Inés |
| author_facet | Pascual, Lourdes Inés Luna, Lorena Celina Gonzalez, Roxana Elizabeth Ortiz, Javier Esteban Gomez Gomez, Luciano Donadel, Osvaldo Juan Hapon, María Belén Feresin, Gabriela Egly Gamarra Luques, Carlos Diego |
| author_sort | Pascual, Lourdes Inés |
| collection | INTA Digital |
| description | Historically, botanical preparations have been used to improve human health. Their active ingredients are influenced by multiple factors such as intraspecies variations, environmental conditions, collection time and methods, and the part of the plant used. To ensure the efficiency and safety of these herbal drugs, qualitative and quantitative analyses are required. A Tessaria absinthioides decoction (DETa) was reported as having hypocholesterolemic, anti-inflammatory, cytotoxic, antitumor, and antioxidative properties. This work aimed to analyze DETa by correlating its chemical composition with cytotoxic and antioxidative properties, with the aim of promoting research on it as an anticancer agent. DETa collections (2017, 2018, 2019, and 2022) were analyzed by UHPLC-DAD, UHPLC-DAD-FLD, and UPLC-MS/MS; cytotoxicity was assessed on the MCF-7 breast cancer cell line; antioxidative capacity was evaluated by the DPPH and FRAP methods; and correlation analysis was used to determine biological and chemical markers. The results provide evidence that biological activities were consistent across the collections. Among the quantified compounds, apigenin, naringin, gallocatechin gallate, ginnalin A, myricetin, epicatechin, OH-tyrosol, quercetin, and chlorogenic, tessaric, p-coumaric, vanillic, caffeic, caftaric, ellagic, and rosmarinic acids correlated as bioactive and chemical markers. Moreover, tessaric acid could be established as a species marker. Altogether, these findings add relevant information to DETa properties, encouraging further exploration of its potential application as an anticancer botanical. |
| format | Artículo |
| id | INTA20297 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA202972024-11-15T12:40:34Z Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology Pascual, Lourdes Inés Luna, Lorena Celina Gonzalez, Roxana Elizabeth Ortiz, Javier Esteban Gomez Gomez, Luciano Donadel, Osvaldo Juan Hapon, María Belén Feresin, Gabriela Egly Gamarra Luques, Carlos Diego Propiedades Medicinales Composición Quimica Polifenoles Oncología Medicinal Properties Chemical Composition Polyphenols Oncology Tessaria absinthioides Historically, botanical preparations have been used to improve human health. Their active ingredients are influenced by multiple factors such as intraspecies variations, environmental conditions, collection time and methods, and the part of the plant used. To ensure the efficiency and safety of these herbal drugs, qualitative and quantitative analyses are required. A Tessaria absinthioides decoction (DETa) was reported as having hypocholesterolemic, anti-inflammatory, cytotoxic, antitumor, and antioxidative properties. This work aimed to analyze DETa by correlating its chemical composition with cytotoxic and antioxidative properties, with the aim of promoting research on it as an anticancer agent. DETa collections (2017, 2018, 2019, and 2022) were analyzed by UHPLC-DAD, UHPLC-DAD-FLD, and UPLC-MS/MS; cytotoxicity was assessed on the MCF-7 breast cancer cell line; antioxidative capacity was evaluated by the DPPH and FRAP methods; and correlation analysis was used to determine biological and chemical markers. The results provide evidence that biological activities were consistent across the collections. Among the quantified compounds, apigenin, naringin, gallocatechin gallate, ginnalin A, myricetin, epicatechin, OH-tyrosol, quercetin, and chlorogenic, tessaric, p-coumaric, vanillic, caffeic, caftaric, ellagic, and rosmarinic acids correlated as bioactive and chemical markers. Moreover, tessaric acid could be established as a species marker. Altogether, these findings add relevant information to DETa properties, encouraging further exploration of its potential application as an anticancer botanical. EEA La Consulta Fil: Pascual, Lourdes Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Pascual, Lourdes Inés. Universidad Nacional de Cuyo. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Pascual, Lourdes Inés. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina Fil: Luna, Lorena Celina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Fil: Luna, Lorena Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: González, Roxana Elizabeth. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Fil: González, Roxana Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Consulta; Argentina Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina Fil: Ortiz, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Gomez Gomez, Luciano. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina Fil: Donadel, Osvaldo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química; Argentina Fil: Donadel, Osvaldo Juan. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina Fil: Hapon, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Hapon, María Belén. Universidad Nacional de Cuyo. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Hapon, María Belén. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Gamarra Luques, Carlos Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Gamarra Luques, Carlos Diego. Universidad Nacional de Cuyo. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Gamarra Luques, Carlos Diego. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina 2024-11-15T12:38:30Z 2024-11-15T12:38:30Z 2024-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/20297 https://www.mdpi.com/2223-7747/13/21/3062 2223-7747 https://doi.org/10.3390/plants13213062 eng info:eu-repograntAgreement/INTA/2019-PD-E7-I152-001, Alimentos nutracéuticos, funcionales o para regímenes especiales info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Plants 13 (21) : 3062. (November 2024) |
| spellingShingle | Propiedades Medicinales Composición Quimica Polifenoles Oncología Medicinal Properties Chemical Composition Polyphenols Oncology Tessaria absinthioides Pascual, Lourdes Inés Luna, Lorena Celina Gonzalez, Roxana Elizabeth Ortiz, Javier Esteban Gomez Gomez, Luciano Donadel, Osvaldo Juan Hapon, María Belén Feresin, Gabriela Egly Gamarra Luques, Carlos Diego Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology |
| title | Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology |
| title_full | Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology |
| title_fullStr | Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology |
| title_full_unstemmed | Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology |
| title_short | Correlation Analysis Among the Chemical Composition and Cytotoxic and Antioxidative Activities of a Tessaria absinthioides Decoction for Endorsing Its Potential Application in Oncology |
| title_sort | correlation analysis among the chemical composition and cytotoxic and antioxidative activities of a tessaria absinthioides decoction for endorsing its potential application in oncology |
| topic | Propiedades Medicinales Composición Quimica Polifenoles Oncología Medicinal Properties Chemical Composition Polyphenols Oncology Tessaria absinthioides |
| url | http://hdl.handle.net/20.500.12123/20297 https://www.mdpi.com/2223-7747/13/21/3062 https://doi.org/10.3390/plants13213062 |
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