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The complete genome of equid herpesvirus‑1 (EHV‑1) feld isolates from Argentina reveals an interspecifc recombinant strain

The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present study analyzed the genome of two isolates obtained from aborted fetuses in Ar...

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Main Authors: Tau, Rocio Lucia, Marandino, Ana Eugenia, Panzera, Yanina, Alamos, Florencia, Vissani, Maria Aldana, Romera, Sonia Alejandra, Perez, Ruben, Maidana, Silvina Soledad
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: Springer 2024
Subjects:
Horses
Herpesviridae
Recombination
Equine Herpesvirus 1
Genomes
Caballos
Recombinación
Herpesvirus Equino 1
Argentina
Genoma
Online Access:http://hdl.handle.net/20.500.12123/20290
https://link.springer.com/article/10.1007/s11262-024-02093-4
https://doi.org/10.1007/s11262-024-02093-4
Summary:The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present study analyzed the genome of two isolates obtained from aborted fetuses in Argentina, E/745/99 and E/1297/07. The E745/99 genome shares 98.2% sequence identity with Ab4, a reference EHV-1 strain. The E/1297/07 genome shares 99.8% identity with NY03, a recombinant strain containing part of ORF64 and part of the intergenic region from Equid alphaherpesvirus-4 (EHV-4). The E/1297/07 genome has the same breakpoints as other United States and Japanese recombinants, including NY03. The recombinant regions have varying numbers of tandem repeat sequences and different minor parental sequences (EHV-4), suggesting distinct origins of the recombinant events. These are the first complete genomes of EHV-1 from Argentina and South America available in the Databases.

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