Apicomplexan profilins in vaccine development applied to bovine neosporosis
Neospora caninum, an intracellular protozoan parasite from the phylum Apicomplexa, is the etiologic agent of neosporosis, a disease considered as a major cause of reproductive loss in cattle and neuromuscular disease in dogs. Bovine neosporosis has a great economic impact in both meat and dairy indu...
| Autores principales: | , |
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| Formato: | info:eu-repo/semantics/article |
| Lenguaje: | Inglés |
| Publicado: |
2018
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/2001 https://www.sciencedirect.com/science/article/pii/S0014489417301443 https://doi.org/10.1016/j.exppara.2017.10.009 |
| _version_ | 1855034887907573760 |
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| author | Mansilla, Florencia Celeste Capozzo, Alejandra |
| author_browse | Capozzo, Alejandra Mansilla, Florencia Celeste |
| author_facet | Mansilla, Florencia Celeste Capozzo, Alejandra |
| author_sort | Mansilla, Florencia Celeste |
| collection | INTA Digital |
| description | Neospora caninum, an intracellular protozoan parasite from the phylum Apicomplexa, is the etiologic agent of neosporosis, a disease considered as a major cause of reproductive loss in cattle and neuromuscular disease in dogs. Bovine neosporosis has a great economic impact in both meat and dairy industries, related to abortion, premature culling and reduced milk yields. Although many efforts have been made to restrain bovine neosporosis, there are still no efficacious control methods. Many vaccine-development studies focused in the apicomplexan proteins involved in the adhesion and invasion of the host cell.
Among these proteins, profilins have recently emerged as potential vaccine antigens or even adjuvant candidates for several diseases caused by apicomplexan parasites. Profilins bind Toll-like receptors 11 and 12 initiating MyD88 signaling, that triggers IL-12 and IFN-g production, which may promote protection against infection. Here we summarized the state-of-the-art of novel vaccine development based on apicomplexan profilins applied as antigens or adjuvants, and delved into recent advances on N. caninum vaccines using profilin in the mouse model and in cattle. |
| format | info:eu-repo/semantics/article |
| id | INTA2001 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| record_format | dspace |
| spelling | INTA20012018-03-09T16:39:41Z Apicomplexan profilins in vaccine development applied to bovine neosporosis Mansilla, Florencia Celeste Capozzo, Alejandra Enfermedades de los Animales Vacunación Ganado Bovino Neospora Caninum Sporozoa Animal Diseases Vaccination Cattle Apicomplexa Neospora caninum, an intracellular protozoan parasite from the phylum Apicomplexa, is the etiologic agent of neosporosis, a disease considered as a major cause of reproductive loss in cattle and neuromuscular disease in dogs. Bovine neosporosis has a great economic impact in both meat and dairy industries, related to abortion, premature culling and reduced milk yields. Although many efforts have been made to restrain bovine neosporosis, there are still no efficacious control methods. Many vaccine-development studies focused in the apicomplexan proteins involved in the adhesion and invasion of the host cell. Among these proteins, profilins have recently emerged as potential vaccine antigens or even adjuvant candidates for several diseases caused by apicomplexan parasites. Profilins bind Toll-like receptors 11 and 12 initiating MyD88 signaling, that triggers IL-12 and IFN-g production, which may promote protection against infection. Here we summarized the state-of-the-art of novel vaccine development based on apicomplexan profilins applied as antigens or adjuvants, and delved into recent advances on N. caninum vaccines using profilin in the mouse model and in cattle. Inst.de Virología Fil: Mansilla, Florencia Celeste. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2018-03-09T12:20:08Z 2018-03-09T12:20:08Z 2017-12 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/2001 https://www.sciencedirect.com/science/article/pii/S0014489417301443 0014-4894 (Print) 1090-2449 (Online) https://doi.org/10.1016/j.exppara.2017.10.009 eng info:eu-repo/semantics/restrictedAccess application/pdf Experimental Parasitology 183 : 64-68 (December 2017) |
| spellingShingle | Enfermedades de los Animales Vacunación Ganado Bovino Neospora Caninum Sporozoa Animal Diseases Vaccination Cattle Apicomplexa Mansilla, Florencia Celeste Capozzo, Alejandra Apicomplexan profilins in vaccine development applied to bovine neosporosis |
| title | Apicomplexan profilins in vaccine development applied to bovine neosporosis |
| title_full | Apicomplexan profilins in vaccine development applied to bovine neosporosis |
| title_fullStr | Apicomplexan profilins in vaccine development applied to bovine neosporosis |
| title_full_unstemmed | Apicomplexan profilins in vaccine development applied to bovine neosporosis |
| title_short | Apicomplexan profilins in vaccine development applied to bovine neosporosis |
| title_sort | apicomplexan profilins in vaccine development applied to bovine neosporosis |
| topic | Enfermedades de los Animales Vacunación Ganado Bovino Neospora Caninum Sporozoa Animal Diseases Vaccination Cattle Apicomplexa |
| url | http://hdl.handle.net/20.500.12123/2001 https://www.sciencedirect.com/science/article/pii/S0014489417301443 https://doi.org/10.1016/j.exppara.2017.10.009 |
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