Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability

In modern agriculture, inoculants, consisting of various bacteria and fungi, are essential for promoting crop growth and sustainability while reducing reliance on agrochemicals. Despite their benefits, there have been no recent significant advances in enhancing their efficacy. Notably, Bradyrhizobiu...

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Autores principales: Serantes, Maria Laura, Stritzler, Margarita, Brambilla, Silvina Maricel, Soto, Gabriela Cynthia, Ayub, Nicolás Daniel
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2024
Materias:
Acceso en línea:http://hdl.handle.net/20.500.12123/19060
https://link.springer.com/article/10.1007/s11240-024-02764-y
https://doi.org/10.1007/s11240-024-02764-y
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author Serantes, Maria Laura
Stritzler, Margarita
Brambilla, Silvina Maricel
Soto, Gabriela Cynthia
Ayub, Nicolás Daniel
author_browse Ayub, Nicolás Daniel
Brambilla, Silvina Maricel
Serantes, Maria Laura
Soto, Gabriela Cynthia
Stritzler, Margarita
author_facet Serantes, Maria Laura
Stritzler, Margarita
Brambilla, Silvina Maricel
Soto, Gabriela Cynthia
Ayub, Nicolás Daniel
author_sort Serantes, Maria Laura
collection INTA Digital
description In modern agriculture, inoculants, consisting of various bacteria and fungi, are essential for promoting crop growth and sustainability while reducing reliance on agrochemicals. Despite their benefits, there have been no recent significant advances in enhancing their efficacy. Notably, Bradyrhizobium japonicum E109 and Bradyrhizobium japonicum SEMIA 5079, the most globally utilized, were isolated decades ago, underscoring the need for genetic enhancement. Recently, efforts have focused on selecting spontaneous mutations in genes associated with denitrification and oxidative stress. While this technology has shown promise in reducing nitrous oxide emissions and enhancing root colonization, selecting mutants remains costly and challenging without clear phenotypic markers. The CRISPR/Cas9 system offers a potential solution, although validation is limited to model strains such as Sinorhizobium meliloti 1021. Using the CRISPR/Cas9 system and three sgRNAs, we have edited the genes 16S, napA and glxA from strains E109 and SEMIA5079, generating mutants with streptomycin tolerance, reduced nitrate reductase activity, and increased catalase activity, respectively. Finally, we discuss how the CRISPR/Cas9 system can contribute to bridging the gap between crop and inoculant improvement, and its possible role in producing a new generation of climate-smart inoculants.
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institution Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina)
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spelling INTA190602024-08-22T10:28:42Z Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability Serantes, Maria Laura Stritzler, Margarita Brambilla, Silvina Maricel Soto, Gabriela Cynthia Ayub, Nicolás Daniel Inoculation Rhizobiaceae Bacteria Soybeans Gene Editing CRISPR Inoculación Soja Edición de Genes Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Interespaciadas Inoculants Inoculantes In modern agriculture, inoculants, consisting of various bacteria and fungi, are essential for promoting crop growth and sustainability while reducing reliance on agrochemicals. Despite their benefits, there have been no recent significant advances in enhancing their efficacy. Notably, Bradyrhizobium japonicum E109 and Bradyrhizobium japonicum SEMIA 5079, the most globally utilized, were isolated decades ago, underscoring the need for genetic enhancement. Recently, efforts have focused on selecting spontaneous mutations in genes associated with denitrification and oxidative stress. While this technology has shown promise in reducing nitrous oxide emissions and enhancing root colonization, selecting mutants remains costly and challenging without clear phenotypic markers. The CRISPR/Cas9 system offers a potential solution, although validation is limited to model strains such as Sinorhizobium meliloti 1021. Using the CRISPR/Cas9 system and three sgRNAs, we have edited the genes 16S, napA and glxA from strains E109 and SEMIA5079, generating mutants with streptomycin tolerance, reduced nitrate reductase activity, and increased catalase activity, respectively. Finally, we discuss how the CRISPR/Cas9 system can contribute to bridging the gap between crop and inoculant improvement, and its possible role in producing a new generation of climate-smart inoculants. Instituto de Biotecnología Fil: Serantes, Maria Laura. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Serantes, Maria Laura. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Stritzler, Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Stritzler, Margarita. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Brambilla, Silvina Maricel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Brambilla, Silvina Maricel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Soto, Gabriela Cinthia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Soto, Gabriela Cinthia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Ayub, Nicolás Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Ayub, Nicolás Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina 2024-08-22T10:19:47Z 2024-08-22T10:19:47Z 2024-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/19060 https://link.springer.com/article/10.1007/s11240-024-02764-y https://doi.org/10.1007/s11240-024-02764-y eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Springer Plant Cell, Tissue and Organ Culture (PCTOC) 157 : 35 (Published online: 22 April 2024)
spellingShingle Inoculation
Rhizobiaceae
Bacteria
Soybeans
Gene Editing
CRISPR
Inoculación
Soja
Edición de Genes
Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Interespaciadas
Inoculants
Inoculantes
Serantes, Maria Laura
Stritzler, Margarita
Brambilla, Silvina Maricel
Soto, Gabriela Cynthia
Ayub, Nicolás Daniel
Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability
title Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability
title_full Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability
title_fullStr Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability
title_full_unstemmed Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability
title_short Genome editing of soybean inoculant using CRISPR/Cas9 system: enhancing agricultural sustainability
title_sort genome editing of soybean inoculant using crispr cas9 system enhancing agricultural sustainability
topic Inoculation
Rhizobiaceae
Bacteria
Soybeans
Gene Editing
CRISPR
Inoculación
Soja
Edición de Genes
Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Interespaciadas
Inoculants
Inoculantes
url http://hdl.handle.net/20.500.12123/19060
https://link.springer.com/article/10.1007/s11240-024-02764-y
https://doi.org/10.1007/s11240-024-02764-y
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