Chronic NOD2 stimulation by MDP confers protection against parthanatos through M2b macrophage polarization in RAW264.7 cells

Innate immune cells show enhanced responsiveness to secondary challenges after an initial non-related stimulation (Trained Innate Immunity, TII). Acute NOD2 activation by Muramyl-Dipeptide (MDP) promotes TII inducing the secretion of pro-inflammatory mediators, while a sustained MDP-stimulation down...

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Bibliographic Details
Main Authors: Mansilla, Florencia Celeste, Miraglia, Maria Cruz, Maidana, Silvina Soledad, Randazzo, Cecilia Paola, Capozzo, Alejandra
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: Elsevier 2024
Subjects:
Online Access:http://hdl.handle.net/20.500.12123/19058
https://www.sciencedirect.com/science/article/pii/S0171298524000512
https://doi.org/10.1016/j.imbio.2024.152833

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