Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges
Macrocyclic lactones (MLs) are the cornerstone of parasite control in livestock due to their broad-spectrum activity against endo (nematodes) and ecto (lice, ticks, mites) parasites. These molecules, introduced into the veterinary pharmaceutical market 40 years ago, have substantially improved anima...
| Autores principales: | , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Elsevier
2024
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/19020 https://www.sciencedirect.com/science/article/pii/S221132072400040X https://doi.org/10.1016/j.ijpddr.2024.100559 |
| _version_ | 1855037958354108416 |
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| author | Lifschitz, Adrian Luis Nava, Santiago Miró, María Victoria Canton, Candela Alvarez, L. Lanusse, Carlos Edmundo |
| author_browse | Alvarez, L. Canton, Candela Lanusse, Carlos Edmundo Lifschitz, Adrian Luis Miró, María Victoria Nava, Santiago |
| author_facet | Lifschitz, Adrian Luis Nava, Santiago Miró, María Victoria Canton, Candela Alvarez, L. Lanusse, Carlos Edmundo |
| author_sort | Lifschitz, Adrian Luis |
| collection | INTA Digital |
| description | Macrocyclic lactones (MLs) are the cornerstone of parasite control in livestock due to their broad-spectrum activity against endo (nematodes) and ecto (lice, ticks, mites) parasites. These molecules, introduced into the veterinary pharmaceutical market 40 years ago, have substantially improved animal welfare and productivity by offering extended high efficacy, reducing treatment frequency, and displaying a favorable safety profile. However, their widespread and intensive use has led to a significant challenge nowadays: the development of parasite resistance. This review focuses on the critical link between drug pharmacokinetics (variation in concentration profiles and exposure over time) and pharmacodynamics (drug efficacy) and the ability of both avermectin and milbemycin MLs families to control livestock ectoparasites. This review discusses the integrated assessment of drug behavior in the host, its diffusion into target parasites, and the impact of different pharmaceutical formulations on enhancing drug delivery to infection sites. These are considered critical research/development areas to optimize the use of MLs, preventing treatment failures and finally extending the lifespan of these essential pharmaceutical ingredients. Finally, the importance of the rational use of MLs, guided by parasite epidemiology and pharmacological knowledge, is emphasized as a key strategy to preserve the antiparasitic efficacy of these still very useful molecules. |
| format | info:ar-repo/semantics/artículo |
| id | INTA19020 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA190202025-05-09T13:29:04Z Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges Lifschitz, Adrian Luis Nava, Santiago Miró, María Victoria Canton, Candela Alvarez, L. Lanusse, Carlos Edmundo Lactones Ectoparasites Parasite Control Drug Resistance Lactona Ectoparásitos Manejo de Parásitos Resistencia a Medicamentos Macrocyclic lactones (MLs) are the cornerstone of parasite control in livestock due to their broad-spectrum activity against endo (nematodes) and ecto (lice, ticks, mites) parasites. These molecules, introduced into the veterinary pharmaceutical market 40 years ago, have substantially improved animal welfare and productivity by offering extended high efficacy, reducing treatment frequency, and displaying a favorable safety profile. However, their widespread and intensive use has led to a significant challenge nowadays: the development of parasite resistance. This review focuses on the critical link between drug pharmacokinetics (variation in concentration profiles and exposure over time) and pharmacodynamics (drug efficacy) and the ability of both avermectin and milbemycin MLs families to control livestock ectoparasites. This review discusses the integrated assessment of drug behavior in the host, its diffusion into target parasites, and the impact of different pharmaceutical formulations on enhancing drug delivery to infection sites. These are considered critical research/development areas to optimize the use of MLs, preventing treatment failures and finally extending the lifespan of these essential pharmaceutical ingredients. Finally, the importance of the rational use of MLs, guided by parasite epidemiology and pharmacological knowledge, is emphasized as a key strategy to preserve the antiparasitic efficacy of these still very useful molecules. Agencia Nacional de Promoción Científica y Tecnológica (PICT 2020-0127), Argentina. Ministerio de Ciencia, Tecnología e Innovación (REDGARR CONVE-2023-100390265-APN-MCT), Argentina. EEA Rafaela Fil: Lifschitz, Adrian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina. Fil: Lifschitz, Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Miró, V. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina. Fil: Miró, V. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Canton, C. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina. Fil: Canton, C. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Alvarez, L. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina. Fil: Alvarez, L. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Lanusse, C. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina. Fil: Lanusse, C. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina 2024-08-21T10:20:52Z 2024-08-21T10:20:52Z 2024-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/19020 https://www.sciencedirect.com/science/article/pii/S221132072400040X 2211-3207 https://doi.org/10.1016/j.ijpddr.2024.100559 eng info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier International Journal for Parasitology: Drugs and Drug Resistance 26 : 100559 (December 2024) |
| spellingShingle | Lactones Ectoparasites Parasite Control Drug Resistance Lactona Ectoparásitos Manejo de Parásitos Resistencia a Medicamentos Lifschitz, Adrian Luis Nava, Santiago Miró, María Victoria Canton, Candela Alvarez, L. Lanusse, Carlos Edmundo Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges |
| title | Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges |
| title_full | Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges |
| title_fullStr | Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges |
| title_full_unstemmed | Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges |
| title_short | Macrocyclic lactones and ectoparasites control in livestock: efficacy, drug resistance and therapeutic challenges |
| title_sort | macrocyclic lactones and ectoparasites control in livestock efficacy drug resistance and therapeutic challenges |
| topic | Lactones Ectoparasites Parasite Control Drug Resistance Lactona Ectoparásitos Manejo de Parásitos Resistencia a Medicamentos |
| url | http://hdl.handle.net/20.500.12123/19020 https://www.sciencedirect.com/science/article/pii/S221132072400040X https://doi.org/10.1016/j.ijpddr.2024.100559 |
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