Evasion of maternal antibody protection by an IBDV Argentine variant
Infectious bursal disease (IBD) is a viral disease that affects the ability of chickens to produce humoral immune responses. One way to prevent the disease is the passage of maternally derived antibodies (MDA) from dams to offsprings via the yolk. Despite sanitary measures, which include immunizatio...
| Main Authors: | , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
Elsevier
2024
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/18428 https://www.sciencedirect.com/science/article/pii/S0032579124000105 https://doi.org/10.1016/j.psj.2024.103431 |
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| author | Jaton, Juan Marcelo Gomez, Evangelina Raquel Lucero, Maria Soledad Rizzi, Lucia Gravisaco, María José Pinto, Silvina Berinstein, Analia Chimeno Zoth, Silvina Andrea |
| author_browse | Berinstein, Analia Chimeno Zoth, Silvina Andrea Gomez, Evangelina Raquel Gravisaco, María José Jaton, Juan Marcelo Lucero, Maria Soledad Pinto, Silvina Rizzi, Lucia |
| author_facet | Jaton, Juan Marcelo Gomez, Evangelina Raquel Lucero, Maria Soledad Rizzi, Lucia Gravisaco, María José Pinto, Silvina Berinstein, Analia Chimeno Zoth, Silvina Andrea |
| author_sort | Jaton, Juan Marcelo |
| collection | INTA Digital |
| description | Infectious bursal disease (IBD) is a viral disease that affects the ability of chickens to produce humoral immune responses. One way to prevent the disease is the passage of maternally derived antibodies (MDA) from dams to offsprings via the yolk. Despite sanitary measures, which include immunization with genogroup 1 (G1) vaccines, infections with IBDV genogroup 4 (G4) in young animals have been detected. The aim of this study was to determine whether a local IBDV isolate belonging to G4 could evade the immunity generated by MDAs. Twelve-day-old animals positive for MDA, were inoculated with G1 or G4 isolates or phosphate buffered saline (PBS) as a control. After 1 wk, the animals were sacrificed and the following parameters were evaluated: bursa-body (BB) ratio, viral load, and histologic damage in the bursa of Fabricius. Results showed that G4-infected animals had significant differences in the BB ratio compared to the PBS group. In addition, viral load was significantly higher in the G4 group than in the G1 group. Histologic damage in the bursa of Fabricius was detected only in G4-infected MDA chickens. Our results suggest that infection with G4 local isolate can circumvent the immunity generated by MDA and, furthermore, that G4 isolate does not differ in its pathogenicity from G1 isolate, which underlines the need to include variant strains in vaccine formulations to reduce potential losses caused by these viruses. |
| format | Artículo |
| id | INTA18428 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA184282024-07-08T15:08:13Z Evasion of maternal antibody protection by an IBDV Argentine variant Jaton, Juan Marcelo Gomez, Evangelina Raquel Lucero, Maria Soledad Rizzi, Lucia Gravisaco, María José Pinto, Silvina Berinstein, Analia Chimeno Zoth, Silvina Andrea Infectious Bursal Disease Virus Gumboro Disease Genetic Isolation Poultry Antibodies Virus Bursitis Infecciosa Enfermedad de Gumboro Aislamiento Genético Argentina Aves de Corral Anticuerpo Maternal Antibody Anticuerpos Maternos Infectious bursal disease (IBD) is a viral disease that affects the ability of chickens to produce humoral immune responses. One way to prevent the disease is the passage of maternally derived antibodies (MDA) from dams to offsprings via the yolk. Despite sanitary measures, which include immunization with genogroup 1 (G1) vaccines, infections with IBDV genogroup 4 (G4) in young animals have been detected. The aim of this study was to determine whether a local IBDV isolate belonging to G4 could evade the immunity generated by MDAs. Twelve-day-old animals positive for MDA, were inoculated with G1 or G4 isolates or phosphate buffered saline (PBS) as a control. After 1 wk, the animals were sacrificed and the following parameters were evaluated: bursa-body (BB) ratio, viral load, and histologic damage in the bursa of Fabricius. Results showed that G4-infected animals had significant differences in the BB ratio compared to the PBS group. In addition, viral load was significantly higher in the G4 group than in the G1 group. Histologic damage in the bursa of Fabricius was detected only in G4-infected MDA chickens. Our results suggest that infection with G4 local isolate can circumvent the immunity generated by MDA and, furthermore, that G4 isolate does not differ in its pathogenicity from G1 isolate, which underlines the need to include variant strains in vaccine formulations to reduce potential losses caused by these viruses. Instituto de Biotecnología Fil: Jaton, Juan Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Jaton, Juan Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gomez, Evangelina Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Gomez, Evangelina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lucero, Maria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Lucero, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rizzi, Lucia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Rizzi, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gravisaco, María José. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Gravisaco, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pinto, Silvina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Patología; Argentina Fil: Berinstein, Analia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Berinstein, Analia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Chimeno Zoth, Silvina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Chimeno Zoth, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2024-07-08T14:34:16Z 2024-07-08T14:34:16Z 2024-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/18428 https://www.sciencedirect.com/science/article/pii/S0032579124000105 1525-3171 https://doi.org/10.1016/j.psj.2024.103431 eng info:eu-repograntAgreement/INTA/2019-PD-E5-I105-001, Patógenos animales: su interacción con el hospedador y el medio ambiente. Impacto en productividad, ecosistemas, sanidad animal y salud pública en el marco ?Una Salud? info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001, Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Poultry Science 103 (3) : 103431 (March 2024) |
| spellingShingle | Infectious Bursal Disease Virus Gumboro Disease Genetic Isolation Poultry Antibodies Virus Bursitis Infecciosa Enfermedad de Gumboro Aislamiento Genético Argentina Aves de Corral Anticuerpo Maternal Antibody Anticuerpos Maternos Jaton, Juan Marcelo Gomez, Evangelina Raquel Lucero, Maria Soledad Rizzi, Lucia Gravisaco, María José Pinto, Silvina Berinstein, Analia Chimeno Zoth, Silvina Andrea Evasion of maternal antibody protection by an IBDV Argentine variant |
| title | Evasion of maternal antibody protection by an IBDV Argentine variant |
| title_full | Evasion of maternal antibody protection by an IBDV Argentine variant |
| title_fullStr | Evasion of maternal antibody protection by an IBDV Argentine variant |
| title_full_unstemmed | Evasion of maternal antibody protection by an IBDV Argentine variant |
| title_short | Evasion of maternal antibody protection by an IBDV Argentine variant |
| title_sort | evasion of maternal antibody protection by an ibdv argentine variant |
| topic | Infectious Bursal Disease Virus Gumboro Disease Genetic Isolation Poultry Antibodies Virus Bursitis Infecciosa Enfermedad de Gumboro Aislamiento Genético Argentina Aves de Corral Anticuerpo Maternal Antibody Anticuerpos Maternos |
| url | http://hdl.handle.net/20.500.12123/18428 https://www.sciencedirect.com/science/article/pii/S0032579124000105 https://doi.org/10.1016/j.psj.2024.103431 |
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