Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination programs are effective strategies for controlling and preventing BoAHV-1 infectio...
| Autores principales: | , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2024
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/18294 https://www.mdpi.com/2076-393X/12/6/615 https://doi.org/10.3390/vaccines12060615 |
| _version_ | 1855037830197149696 |
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| author | Camargo, Luana Franklin, Yasmin Vieira da Silva, Gustavo Feliciano Resende Santos, Janaína Ferreira Parreño, Gladys Viviana Wigdorovitz, Andres Gomes, Viviani |
| author_browse | Camargo, Luana Franklin, Yasmin Vieira Gomes, Viviani Parreño, Gladys Viviana Santos, Janaína Ferreira Wigdorovitz, Andres da Silva, Gustavo Feliciano Resende |
| author_facet | Camargo, Luana Franklin, Yasmin Vieira da Silva, Gustavo Feliciano Resende Santos, Janaína Ferreira Parreño, Gladys Viviana Wigdorovitz, Andres Gomes, Viviani |
| author_sort | Camargo, Luana |
| collection | INTA Digital |
| description | Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination programs are effective strategies for controlling and preventing BoAHV-1 infection and transmission. We evaluated the serological immune response against BoAHV-1 induced by eight different formulations of commercial vaccines: three modified live vaccines and five killed vaccines containing BoAHV type 1 or types 1 and 5. In the first experiment, 50 BoAHV-1-seronegative guinea pigs were assigned to eight groups; each individual in the treatment groups received two doses (one-fifth of the bovine dose). The second experiment was conducted using 29 crossbred Holstein × Gir heifers in four groups of six to nine animals each. The serological immune response against BoAHV-1 was measured using virus neutralization and enzyme-linked immunosorbent assays to measure the total IgG against BoAHV. We evaluated the effects of the vaccine, time, and interaction of the vaccine and time on neutralizing antibodies against BoAHV-1. Killed vaccines produced low levels of antibodies against BoAHV-1, whereas modified live vaccines produced high levels of antibodies capable of providing neutralizing titers in the vaccinated animals, with the thermosensitive modified live vaccine showing the highest levels of antibodies. |
| format | info:ar-repo/semantics/artículo |
| id | INTA18294 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA182942024-06-28T11:02:24Z Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations Camargo, Luana Franklin, Yasmin Vieira da Silva, Gustavo Feliciano Resende Santos, Janaína Ferreira Parreño, Gladys Viviana Wigdorovitz, Andres Gomes, Viviani Vaccination Dairy Cattle Vaccines Antibodies Guinea Pigs Heifers Vacunación Ganado de Leche Vacuna Anticuerpos Cobaya Novilla Bovine alphaherpesvirus 1 Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination programs are effective strategies for controlling and preventing BoAHV-1 infection and transmission. We evaluated the serological immune response against BoAHV-1 induced by eight different formulations of commercial vaccines: three modified live vaccines and five killed vaccines containing BoAHV type 1 or types 1 and 5. In the first experiment, 50 BoAHV-1-seronegative guinea pigs were assigned to eight groups; each individual in the treatment groups received two doses (one-fifth of the bovine dose). The second experiment was conducted using 29 crossbred Holstein × Gir heifers in four groups of six to nine animals each. The serological immune response against BoAHV-1 was measured using virus neutralization and enzyme-linked immunosorbent assays to measure the total IgG against BoAHV. We evaluated the effects of the vaccine, time, and interaction of the vaccine and time on neutralizing antibodies against BoAHV-1. Killed vaccines produced low levels of antibodies against BoAHV-1, whereas modified live vaccines produced high levels of antibodies capable of providing neutralizing titers in the vaccinated animals, with the thermosensitive modified live vaccine showing the highest levels of antibodies. Instituto de Virología Fil: Camargo, Luana. Universidade de São Paulo. Department of Medical Clinic; Brasil Fil: Franklin, Yasmin Vieira. Universidade de São Paulo. Department of Medical Clinic; Brasil Fil: da Silva, Gustavo Feliciano Resende. Universidade Federal de Goiânia. Department of Animal Production; Brasil Fil: Santos, Janaína Ferreira. Universidade de São Paulo. Department of Medical Clinic; Brasil Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virologia e Innovaciones Tecnologicas (IVIT); Argentina Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas (IVIT); Argentina Fil: Gomes, Viviani. Universidade de São Paulo. Department of Medical Clinic; Brasil 2024-06-28T10:55:49Z 2024-06-28T10:55:49Z 2024-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/18294 https://www.mdpi.com/2076-393X/12/6/615 2076-393X https://doi.org/10.3390/vaccines12060615 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Vaccines 12 (6) : 615 (Junio 2024) |
| spellingShingle | Vaccination Dairy Cattle Vaccines Antibodies Guinea Pigs Heifers Vacunación Ganado de Leche Vacuna Anticuerpos Cobaya Novilla Bovine alphaherpesvirus 1 Camargo, Luana Franklin, Yasmin Vieira da Silva, Gustavo Feliciano Resende Santos, Janaína Ferreira Parreño, Gladys Viviana Wigdorovitz, Andres Gomes, Viviani Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations |
| title | Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations |
| title_full | Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations |
| title_fullStr | Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations |
| title_full_unstemmed | Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations |
| title_short | Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations |
| title_sort | serological responses of guinea pigs and heifers to eight different boahv 1 vaccine formulations |
| topic | Vaccination Dairy Cattle Vaccines Antibodies Guinea Pigs Heifers Vacunación Ganado de Leche Vacuna Anticuerpos Cobaya Novilla Bovine alphaherpesvirus 1 |
| url | http://hdl.handle.net/20.500.12123/18294 https://www.mdpi.com/2076-393X/12/6/615 https://doi.org/10.3390/vaccines12060615 |
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