Acute atrazine intoxication in heifers: Case report and toxicological studies
Atrazine is a triazine organochloride herbicide, frequently used in different agricultural activities. Rare acute intoxication with atrazine is reported in production animals, and its metabolism in mammals is unknown. We report a spontaneous case of atrazine acute intoxication in 16.1% animals of a...
| Autores principales: | , , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2024
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/18254 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3754 https://doi.org/10.1002/dta.3754 |
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| author | Marron, Yolanda De Geronimo, Eduardo Poo, Juan Ignacio Garcia, Juan Agustin Rustichelli Millán, Gina Britos, Gastón Lázaro, Fermín Canton, German Jose |
| author_browse | Britos, Gastón Canton, German Jose De Geronimo, Eduardo Garcia, Juan Agustin Lázaro, Fermín Marron, Yolanda Poo, Juan Ignacio Rustichelli Millán, Gina |
| author_facet | Marron, Yolanda De Geronimo, Eduardo Poo, Juan Ignacio Garcia, Juan Agustin Rustichelli Millán, Gina Britos, Gastón Lázaro, Fermín Canton, German Jose |
| author_sort | Marron, Yolanda |
| collection | INTA Digital |
| description | Atrazine is a triazine organochloride herbicide, frequently used in different agricultural activities. Rare acute intoxication with atrazine is reported in production animals, and its metabolism in mammals is unknown. We report a spontaneous case of atrazine acute intoxication in 16.1% animals of a 168-beef heifer herd exposed to the herbicide at a farm located in Buenos Aires province, Argentina. Affected heifers showed different neurological signs and died suddenly, similar to the previous natural atrazine intoxication report. During autopsy, no gross lesions were observed. Different body fluids and tissues samples were collected during postmortem examination. No relevant histopathological findings were observed. High levels of atrazine and its metabolites were detected in different fluids and tissues by ultra-liquid chromatography high performance coupled to triple quadrupole mass spectrometry. These findings suggest ruminal or hepatic metabolization of atrazine in the exposed cattle. This is the first report of quantification and distribution of atrazine and its metabolites in intoxicated mammals providing relevant information for diagnostic purposes. |
| format | info:ar-repo/semantics/artículo |
| id | INTA18254 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA182542024-06-25T11:19:42Z Acute atrazine intoxication in heifers: Case report and toxicological studies Marron, Yolanda De Geronimo, Eduardo Poo, Juan Ignacio Garcia, Juan Agustin Rustichelli Millán, Gina Britos, Gastón Lázaro, Fermín Canton, German Jose Herbicidas Metabolismo Envenenamiento Rumiante Atrazina Herbicides Metabolism Poisoing Ruminants Atrazine Heifers Cattle Novilla Ganado Bovino Atrazine is a triazine organochloride herbicide, frequently used in different agricultural activities. Rare acute intoxication with atrazine is reported in production animals, and its metabolism in mammals is unknown. We report a spontaneous case of atrazine acute intoxication in 16.1% animals of a 168-beef heifer herd exposed to the herbicide at a farm located in Buenos Aires province, Argentina. Affected heifers showed different neurological signs and died suddenly, similar to the previous natural atrazine intoxication report. During autopsy, no gross lesions were observed. Different body fluids and tissues samples were collected during postmortem examination. No relevant histopathological findings were observed. High levels of atrazine and its metabolites were detected in different fluids and tissues by ultra-liquid chromatography high performance coupled to triple quadrupole mass spectrometry. These findings suggest ruminal or hepatic metabolization of atrazine in the exposed cattle. This is the first report of quantification and distribution of atrazine and its metabolites in intoxicated mammals providing relevant information for diagnostic purposes. EEA Balcarce Fil: Marron, Yolanda. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: De Gerónimo, Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Poo, Juan Ignacio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: García, Juan Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Rustichelli Millán, Gina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Britos, Gastón. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Lázaro, Fermín. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina 2024-06-25T11:06:12Z 2024-06-25T11:06:12Z 2024-06-23 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/18254 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3754 1942-7611 (online) 1942-7603 (print) https://doi.org/10.1002/dta.3754 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Wiley Drug Testing and Analysis : 1-4 (23 June 2024) |
| spellingShingle | Herbicidas Metabolismo Envenenamiento Rumiante Atrazina Herbicides Metabolism Poisoing Ruminants Atrazine Heifers Cattle Novilla Ganado Bovino Marron, Yolanda De Geronimo, Eduardo Poo, Juan Ignacio Garcia, Juan Agustin Rustichelli Millán, Gina Britos, Gastón Lázaro, Fermín Canton, German Jose Acute atrazine intoxication in heifers: Case report and toxicological studies |
| title | Acute atrazine intoxication in heifers: Case report and toxicological studies |
| title_full | Acute atrazine intoxication in heifers: Case report and toxicological studies |
| title_fullStr | Acute atrazine intoxication in heifers: Case report and toxicological studies |
| title_full_unstemmed | Acute atrazine intoxication in heifers: Case report and toxicological studies |
| title_short | Acute atrazine intoxication in heifers: Case report and toxicological studies |
| title_sort | acute atrazine intoxication in heifers case report and toxicological studies |
| topic | Herbicidas Metabolismo Envenenamiento Rumiante Atrazina Herbicides Metabolism Poisoing Ruminants Atrazine Heifers Cattle Novilla Ganado Bovino |
| url | http://hdl.handle.net/20.500.12123/18254 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.3754 https://doi.org/10.1002/dta.3754 |
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