Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina
Infectious Bursal Disease is a highly contagious disease that affects young chickens and leads to significant economic losses. Its causal agent is a double-stranded RNA virus that, due to its high error rate during the replication process, gives rise to a constant generation of new virus variants. U...
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| Format: | Artículo |
| Language: | Inglés |
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Elsevier
2024
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| Online Access: | http://hdl.handle.net/20.500.12123/18215 https://www.sciencedirect.com/science/article/pii/S0032579124002025 https://doi.org/10.1016/j.psj.2024.103623 |
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| author | Jaton, Juan Marcelo Lozano Calderon, Laura Camila Gambini, Pablo Ponti, Marina Gomez, Evangelina Raquel Konig, Guido Alberto Chimeno Zoth, Silvina Andrea |
| author_browse | Chimeno Zoth, Silvina Andrea Gambini, Pablo Gomez, Evangelina Raquel Jaton, Juan Marcelo Konig, Guido Alberto Lozano Calderon, Laura Camila Ponti, Marina |
| author_facet | Jaton, Juan Marcelo Lozano Calderon, Laura Camila Gambini, Pablo Ponti, Marina Gomez, Evangelina Raquel Konig, Guido Alberto Chimeno Zoth, Silvina Andrea |
| author_sort | Jaton, Juan Marcelo |
| collection | INTA Digital |
| description | Infectious Bursal Disease is a highly contagious disease that affects young chickens and leads to significant economic losses. Its causal agent is a double-stranded RNA virus that, due to its high error rate during the replication process, gives rise to a constant generation of new virus variants. Until 2014, strains of Infectious Bursal Diseases Virus (IBDV) belonging to genogroup 4 predominated in Argentina, but there have been no reports since then regarding the circulating genogroups in poultry. In this study, 11 recent sequences of Argentine from the hypervariable region of VP2 protein (hvVP2) were analyzed to determine their genogroup, origin, evolution, and amino acid sequence. Samples from chickens showing signs of IBDV infection were collected, and the hvVP2 region was amplified using RT-PCR, followed by sequencing. The results indicated that the analyzed strains belong to genogroup 2, with an estimated evolutionary rate of 1.74 × 10−3 substitutions/site/year. It is speculated that the predominant group of sequences began to spread in Argentina around 2014 and had its origins in China. Another sample is related to strains from South Korea and is not closely linked to the main group. Furthermore, the predicted amino acid sequences show similarity to strains that can evade vaccine-induced immunity. These findings underscore the importance of active surveillance in poultry to mitigate losses caused by IBDV. |
| format | Artículo |
| id | INTA18215 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA182152024-06-19T13:53:50Z Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina Jaton, Juan Marcelo Lozano Calderon, Laura Camila Gambini, Pablo Ponti, Marina Gomez, Evangelina Raquel Konig, Guido Alberto Chimeno Zoth, Silvina Andrea Epidemiology Infectious Bursal Disease Virus Molecular Phylogenetics Phylogeography Epidemiología Virus Bursitis Infecciosa Filogenética Molecular Filogeografía Argentina Infectious Bursal Disease is a highly contagious disease that affects young chickens and leads to significant economic losses. Its causal agent is a double-stranded RNA virus that, due to its high error rate during the replication process, gives rise to a constant generation of new virus variants. Until 2014, strains of Infectious Bursal Diseases Virus (IBDV) belonging to genogroup 4 predominated in Argentina, but there have been no reports since then regarding the circulating genogroups in poultry. In this study, 11 recent sequences of Argentine from the hypervariable region of VP2 protein (hvVP2) were analyzed to determine their genogroup, origin, evolution, and amino acid sequence. Samples from chickens showing signs of IBDV infection were collected, and the hvVP2 region was amplified using RT-PCR, followed by sequencing. The results indicated that the analyzed strains belong to genogroup 2, with an estimated evolutionary rate of 1.74 × 10−3 substitutions/site/year. It is speculated that the predominant group of sequences began to spread in Argentina around 2014 and had its origins in China. Another sample is related to strains from South Korea and is not closely linked to the main group. Furthermore, the predicted amino acid sequences show similarity to strains that can evade vaccine-induced immunity. These findings underscore the importance of active surveillance in poultry to mitigate losses caused by IBDV. Instituto de Biotecnología Fil: Jaton, Juan Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Jaton, Juan Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lozano Calderon, Laura Camila. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; Argentina Fil: Lozano Calderon, Laura Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gambini, Pablo. HIPRA Argentina S.A.; Argentina Fil: Ponti, Marina. HIPRA Argentina S.A.; Argentina Fil: Gomez, Evangelina Raquel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Gomez, Evangelina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Epidemiología Molecular y Evolución Viral; Argentina Fil: Konig, Guido Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Chimeno Zoth, Silvina Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular. Laboratorio de Inmunología y Vacunas Aviares; Argentina Fil: Chimeno Zoth, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2024-06-19T13:37:50Z 2024-06-19T13:37:50Z 2024-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/18215 https://www.sciencedirect.com/science/article/pii/S0032579124002025 1525-3171 https://doi.org/10.1016/j.psj.2024.103623 eng info:eu-repograntAgreement/INTA/2023-PD-L01-I089, Microbiomas en ecosistemas agropecuarios: la conexión integradora del enfoque Una Salud info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Poultry Science 103 (6) : 103623 (June 2024) |
| spellingShingle | Epidemiology Infectious Bursal Disease Virus Molecular Phylogenetics Phylogeography Epidemiología Virus Bursitis Infecciosa Filogenética Molecular Filogeografía Argentina Jaton, Juan Marcelo Lozano Calderon, Laura Camila Gambini, Pablo Ponti, Marina Gomez, Evangelina Raquel Konig, Guido Alberto Chimeno Zoth, Silvina Andrea Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina |
| title | Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina |
| title_full | Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina |
| title_fullStr | Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina |
| title_full_unstemmed | Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina |
| title_short | Research Note : Characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in Argentina |
| title_sort | research note characterization and phylodynamic analysis of new infectious bursal disease virus variants circulating in argentina |
| topic | Epidemiology Infectious Bursal Disease Virus Molecular Phylogenetics Phylogeography Epidemiología Virus Bursitis Infecciosa Filogenética Molecular Filogeografía Argentina |
| url | http://hdl.handle.net/20.500.12123/18215 https://www.sciencedirect.com/science/article/pii/S0032579124002025 https://doi.org/10.1016/j.psj.2024.103623 |
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