The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle
Neospora caninum is one of the most frequently diagnosed abortifacient pathogens in cattle. There is abundant genomic information about the parasite itself, but very little is known about the genetic variability of resistance in the most common intermediate host. The aim of this review was to compil...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Wiley
2024
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| Online Access: | http://hdl.handle.net/20.500.12123/17818 https://onlinelibrary.wiley.com/doi/10.1111/age.13410 https://doi.org/10.1111/age.13410 |
| _version_ | 1855037742086356992 |
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| author | Dinon, María Anabella Fiorani, Franco Campero, Lucia Maria Moore, Prando Dadin Corva, Pablo |
| author_browse | Campero, Lucia Maria Corva, Pablo Dinon, María Anabella Fiorani, Franco Moore, Prando Dadin |
| author_facet | Dinon, María Anabella Fiorani, Franco Campero, Lucia Maria Moore, Prando Dadin Corva, Pablo |
| author_sort | Dinon, María Anabella |
| collection | INTA Digital |
| description | Neospora caninum is one of the most frequently diagnosed abortifacient pathogens in cattle. There is abundant genomic information about the parasite itself, but very little is known about the genetic variability of resistance in the most common intermediate host. The aim of this review was to compile all the available information about the genetic variability associated with the resistance to N. caninum both between and within cattle breeds. We systematically searched for published studies that investigated the influence of genetics of the host on the prevalence of N. caninum and risk of abortion. Beyond the potential confounding effects of feeding systems, management and animal density, some lines of evidence suggest that Holstein, the most popular breed for milk production, has a comparatively higher risk of abortion due to infections by N. caninum, whereas some beef breeds from Continental Europe seem to be more resistant. It is still not clear if different genetic mechanisms of resistance are involved in the two known routes of infection: postnatal ingestion of oocysts or transplacental transmission from the infected dam to the fetus. Genomic information associated with susceptibility to infection and risk of abortion in different cattle breeds is still scarce. The information reported here could be useful to identify new research alternatives and to define novel strategies to deal with this major problem of animal production. |
| format | info:ar-repo/semantics/artículo |
| id | INTA17818 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA178182024-05-21T11:33:52Z The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle Dinon, María Anabella Fiorani, Franco Campero, Lucia Maria Moore, Prando Dadin Corva, Pablo Ganado de Leche Ganado de Carne Neospora Caninum Genética Resistencia a la Enfermedad Dairy Cattle Beef Cattle Genetics Disease Resistance Genetic Variation Variación Genética Neospora caninum is one of the most frequently diagnosed abortifacient pathogens in cattle. There is abundant genomic information about the parasite itself, but very little is known about the genetic variability of resistance in the most common intermediate host. The aim of this review was to compile all the available information about the genetic variability associated with the resistance to N. caninum both between and within cattle breeds. We systematically searched for published studies that investigated the influence of genetics of the host on the prevalence of N. caninum and risk of abortion. Beyond the potential confounding effects of feeding systems, management and animal density, some lines of evidence suggest that Holstein, the most popular breed for milk production, has a comparatively higher risk of abortion due to infections by N. caninum, whereas some beef breeds from Continental Europe seem to be more resistant. It is still not clear if different genetic mechanisms of resistance are involved in the two known routes of infection: postnatal ingestion of oocysts or transplacental transmission from the infected dam to the fetus. Genomic information associated with susceptibility to infection and risk of abortion in different cattle breeds is still scarce. The information reported here could be useful to identify new research alternatives and to define novel strategies to deal with this major problem of animal production. EEA Balcarce Fil: Dinon, María Anabella. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina Fil: Fiorani, Franco. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina Fil: Campero, Lucía María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Moore, Dadin Prando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina Fil: Moore, Dadin Prando. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina Fil: Corva, Pablo Marcelo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina 2024-05-21T11:20:11Z 2024-05-21T11:20:11Z 2024-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/17818 https://onlinelibrary.wiley.com/doi/10.1111/age.13410 0268-9146 https://doi.org/10.1111/age.13410 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Wiley Animal Genetics 55 (3) : 304-318 (June 2024) |
| spellingShingle | Ganado de Leche Ganado de Carne Neospora Caninum Genética Resistencia a la Enfermedad Dairy Cattle Beef Cattle Genetics Disease Resistance Genetic Variation Variación Genética Dinon, María Anabella Fiorani, Franco Campero, Lucia Maria Moore, Prando Dadin Corva, Pablo The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle |
| title | The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle |
| title_full | The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle |
| title_fullStr | The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle |
| title_full_unstemmed | The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle |
| title_short | The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle |
| title_sort | role of genetic variability of the host on the resistance to neospora caninum infection in cattle |
| topic | Ganado de Leche Ganado de Carne Neospora Caninum Genética Resistencia a la Enfermedad Dairy Cattle Beef Cattle Genetics Disease Resistance Genetic Variation Variación Genética |
| url | http://hdl.handle.net/20.500.12123/17818 https://onlinelibrary.wiley.com/doi/10.1111/age.13410 https://doi.org/10.1111/age.13410 |
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