In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Taylor & Francis Group
2024
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| Online Access: | http://hdl.handle.net/20.500.12123/16818 https://www.tandfonline.com/doi/full/10.1080/19476337.2023.2298569 https://doi.org/10.1080/19476337.2023.2298569 |
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| author | Hugo, Ayelén A. Serradell, María De los Ángeles Peri, Pablo Luis Farina, Sebastián Gomez-Zavaglia, Andrea |
| author_browse | Farina, Sebastián Gomez-Zavaglia, Andrea Hugo, Ayelén A. Peri, Pablo Luis Serradell, María De los Ángeles |
| author_facet | Hugo, Ayelén A. Serradell, María De los Ángeles Peri, Pablo Luis Farina, Sebastián Gomez-Zavaglia, Andrea |
| author_sort | Hugo, Ayelén A. |
| collection | INTA Digital |
| description | Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves
infusion and suggest their contribution for modulating the intestinal oxidative stress. |
| format | info:ar-repo/semantics/artículo |
| id | INTA16818 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Taylor & Francis Group |
| publisherStr | Taylor & Francis Group |
| record_format | dspace |
| spelling | INTA168182024-02-28T12:21:14Z In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves Hugo, Ayelén A. Serradell, María De los Ángeles Peri, Pablo Luis Farina, Sebastián Gomez-Zavaglia, Andrea Nothofagus Bosques Primarios Uso Múltiple Hojas Infusión Propiedades Antioxidantes Toxicidad Ratones Polifenoles Flavonoides Ensayos de Toxicidad Histopatología Primary Forests Multiple Use Leaves Infusion Antioxidant Properties Toxicity Mice Polyphenols Flavonoids Toxicity Tests Histopathology Antioxidant Activity Animal Model Biological Samples Plasma Biochemistry Antioxidant Capacity Actividad Antioxidante Ñire Nothofagus antarctica Modelo Animal Muestras Biológicas Bioquímica Plasmática Capacidad Antioxidante Región Patagónica Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress. EEA Santa Cruz Fil: Hugo, Ayelén A. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina. Fil: Serradell, María De los Ángeles. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Microbiología; Argentina. Fil: Peri, Pablo Luis. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Santa Cruz; Argentina. Fil: Peri, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Peri, Pablo Luis. Universidad Nacional de la Patagonia Austral; Argentina. Fil: Farina, Sebastián. Gobierno de Tierra del Fuego, Antártida e Islas del Atlántico Sur. Ministerio de Producción y Ambiente. Secretaría de Desarrollo Productivo y PyME. Dirección General de Desarrollo Forestal; Argentina. Fil: Gomez-Zavaglia, Andrea. Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET La Plata); Argentina. 2024-02-28T11:49:16Z 2024-02-28T11:49:16Z 2024-01-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/16818 https://www.tandfonline.com/doi/full/10.1080/19476337.2023.2298569 Hugo A.A.; Serradell M.A.; Peri P.L.; Farina S.; Gómez-Zavaglia A. (2024) In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves. CyTA-Journal of Food 22(1): e2298569. https://doi.org/10.1080/19476337.2023.2298569 1947-6345 (Online) 1947-6337 (print) https://doi.org/10.1080/19476337.2023.2298569 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Taylor & Francis Group CyTA-Journal of Food 22 (1) : e2298569. (January 2024) |
| spellingShingle | Nothofagus Bosques Primarios Uso Múltiple Hojas Infusión Propiedades Antioxidantes Toxicidad Ratones Polifenoles Flavonoides Ensayos de Toxicidad Histopatología Primary Forests Multiple Use Leaves Infusion Antioxidant Properties Toxicity Mice Polyphenols Flavonoids Toxicity Tests Histopathology Antioxidant Activity Animal Model Biological Samples Plasma Biochemistry Antioxidant Capacity Actividad Antioxidante Ñire Nothofagus antarctica Modelo Animal Muestras Biológicas Bioquímica Plasmática Capacidad Antioxidante Región Patagónica Hugo, Ayelén A. Serradell, María De los Ángeles Peri, Pablo Luis Farina, Sebastián Gomez-Zavaglia, Andrea In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
| title | In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
| title_full | In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
| title_fullStr | In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
| title_full_unstemmed | In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
| title_short | In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
| title_sort | in vivo oral toxicity and antioxidant capacity of nothofagus antarctica g forst oerst nire leaves |
| topic | Nothofagus Bosques Primarios Uso Múltiple Hojas Infusión Propiedades Antioxidantes Toxicidad Ratones Polifenoles Flavonoides Ensayos de Toxicidad Histopatología Primary Forests Multiple Use Leaves Infusion Antioxidant Properties Toxicity Mice Polyphenols Flavonoids Toxicity Tests Histopathology Antioxidant Activity Animal Model Biological Samples Plasma Biochemistry Antioxidant Capacity Actividad Antioxidante Ñire Nothofagus antarctica Modelo Animal Muestras Biológicas Bioquímica Plasmática Capacidad Antioxidante Región Patagónica |
| url | http://hdl.handle.net/20.500.12123/16818 https://www.tandfonline.com/doi/full/10.1080/19476337.2023.2298569 https://doi.org/10.1080/19476337.2023.2298569 |
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