Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties
Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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MDPI
2024
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/16796 https://www.mdpi.com/1420-3049/29/4/814 https://doi.org/10.3390/molecules29040814 |
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| author | Borgo, Jimena Wagner, Mariel S. Laurella, Laura C. Elso, Orlando G. Selener, Mariana G. Clavin, María Bach, Hernán Gerónimo Catalan, César A.N. Bivona, Augusto E. Sepúlveda, Claudia S. Sülsen, Valeria P. |
| author_browse | Bach, Hernán Gerónimo Bivona, Augusto E. Borgo, Jimena Catalan, César A.N. Clavin, María Elso, Orlando G. Laurella, Laura C. Selener, Mariana G. Sepúlveda, Claudia S. Sülsen, Valeria P. Wagner, Mariel S. |
| author_facet | Borgo, Jimena Wagner, Mariel S. Laurella, Laura C. Elso, Orlando G. Selener, Mariana G. Clavin, María Bach, Hernán Gerónimo Catalan, César A.N. Bivona, Augusto E. Sepúlveda, Claudia S. Sülsen, Valeria P. |
| author_sort | Borgo, Jimena |
| collection | INTA Digital |
| description | Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared from six Asteraceae species, including Acmella bellidioides, Campuloclinium macrocephalum, Grindelia pulchella, Grindelia chiloensis, Helenium radiatum, and Viguiera tuberosa, along with pure phytochemicals isolated from Asteraceae: mikanolide (1), eupatoriopicrin (2), eupahakonenin B (3), minimolide (4), estafietin (5), 2-oxo-8-deoxyligustrin (6), santhemoidin C (7), euparin (8), jaceidin (9), nepetin (10), jaceosidin (11), eryodictiol (12), eupatorin (13), and 5-demethylsinensetin (14). Results showed that the dichloromethane extracts of C. macrocephalum and H. radiatum and the methanolic extracts prepared from C. macrocephalum and G. pulchella were highly active and selective against DENV-2, affording EC50 values of 0.11, 0.15, 1.80, and 3.85 µg/mL, respectively, and SIs of 171.0, 18.8, >17.36, and 64.9, respectively. From the pool of phytochemicals tested, compounds 6, 7, and 8 stand out as the most active (EC50 = 3.7, 3.1, and 6.8 µM, respectively; SI = 5.9, 6.7, and >73.4, respectively). These results demonstrate that Asteraceae species and their chemical constituents represent valuable sources of new antiviral molecules. |
| format | Artículo |
| id | INTA16796 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA167962024-02-26T12:57:00Z Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties Borgo, Jimena Wagner, Mariel S. Laurella, Laura C. Elso, Orlando G. Selener, Mariana G. Clavin, María Bach, Hernán Gerónimo Catalan, César A.N. Bivona, Augusto E. Sepúlveda, Claudia S. Sülsen, Valeria P. Asteraceae Extractos Vegetales Fitoquímicos Propiedades Antimicrobianas Plant Extracts Phytochemicals Antimicrobial Properties Propiedades Antivirales Antiviral Properties Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared from six Asteraceae species, including Acmella bellidioides, Campuloclinium macrocephalum, Grindelia pulchella, Grindelia chiloensis, Helenium radiatum, and Viguiera tuberosa, along with pure phytochemicals isolated from Asteraceae: mikanolide (1), eupatoriopicrin (2), eupahakonenin B (3), minimolide (4), estafietin (5), 2-oxo-8-deoxyligustrin (6), santhemoidin C (7), euparin (8), jaceidin (9), nepetin (10), jaceosidin (11), eryodictiol (12), eupatorin (13), and 5-demethylsinensetin (14). Results showed that the dichloromethane extracts of C. macrocephalum and H. radiatum and the methanolic extracts prepared from C. macrocephalum and G. pulchella were highly active and selective against DENV-2, affording EC50 values of 0.11, 0.15, 1.80, and 3.85 µg/mL, respectively, and SIs of 171.0, 18.8, >17.36, and 64.9, respectively. From the pool of phytochemicals tested, compounds 6, 7, and 8 stand out as the most active (EC50 = 3.7, 3.1, and 6.8 µM, respectively; SI = 5.9, 6.7, and >73.4, respectively). These results demonstrate that Asteraceae species and their chemical constituents represent valuable sources of new antiviral molecules. EEA AMBA Fil: Borgo, Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Borgo, Jimena. Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina Fil: Borgo, Jimena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Fil. Wagner, Mariel S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Estrategias Antivirales; Argentina Fil: Laurella, Laura C. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Laurella, Laura C. Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina Fil: Laurella, Laura C. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Fil: Elso, Orlando G. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Fil: Elso, Orlando G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR); Argentina Fil: Elso, Orlando G. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR); Argentina Fil: Selener, Mariana G. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Fil: Clavin, Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria AMBA; Argentina Fil: Catalán, César A. N. Universidad Nacional de Tucumán. Facultad de Bioquímica Química y Farmacia. Instituto de Química Orgánica; Argentina Fil: Bivona, Augusto E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni (IDEHU); Argentina Fil: Bivona, Augusto E. Universidad de Buenos Aires. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni (IDEHU); Argentina Fil: Bivona, Augusto E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina Fil: Bivona, Augusto E. Universidad de Buenos Aires. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina Fil: Sepúlveda, Claudia S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica; Argentina Fil: Sepúlveda, Claudia S. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química Biológica; Argentina Fil: Sülsen, Valeria P. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Sülsen, Valeria P. Universidad de Buenos Aires. Instituto de Química y Metabolismo del Fármaco (IQUIMEFA); Argentina Fil: Sülsen, Valeria P. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. 2024-02-26T12:54:39Z 2024-02-26T12:54:39Z 2024-02 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/16796 https://www.mdpi.com/1420-3049/29/4/814 1420-3049 https://doi.org/10.3390/molecules29040814 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Molecules 29 (4) : 814. (February 2024) |
| spellingShingle | Asteraceae Extractos Vegetales Fitoquímicos Propiedades Antimicrobianas Plant Extracts Phytochemicals Antimicrobial Properties Propiedades Antivirales Antiviral Properties Borgo, Jimena Wagner, Mariel S. Laurella, Laura C. Elso, Orlando G. Selener, Mariana G. Clavin, María Bach, Hernán Gerónimo Catalan, César A.N. Bivona, Augusto E. Sepúlveda, Claudia S. Sülsen, Valeria P. Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties |
| title | Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties |
| title_full | Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties |
| title_fullStr | Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties |
| title_full_unstemmed | Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties |
| title_short | Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties |
| title_sort | plant extracts and phytochemicals from the asteraceae family with antiviral properties |
| topic | Asteraceae Extractos Vegetales Fitoquímicos Propiedades Antimicrobianas Plant Extracts Phytochemicals Antimicrobial Properties Propiedades Antivirales Antiviral Properties |
| url | http://hdl.handle.net/20.500.12123/16796 https://www.mdpi.com/1420-3049/29/4/814 https://doi.org/10.3390/molecules29040814 |
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