Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are...
| Autores principales: | , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Wiley
2024
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/16601 https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14522 https://doi.org/10.1002/1873-3468.14522 |
| _version_ | 1855037512830943232 |
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| author | Toscani, Andrés Martin Aguilera, Pablo Nicolás Coluccio Leskow, Federico |
| author_browse | Aguilera, Pablo Nicolás Coluccio Leskow, Federico Toscani, Andrés Martin |
| author_facet | Toscani, Andrés Martin Aguilera, Pablo Nicolás Coluccio Leskow, Federico |
| author_sort | Toscani, Andrés Martin |
| collection | INTA Digital |
| description | The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway. |
| format | info:ar-repo/semantics/artículo |
| id | INTA16601 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA166012024-02-14T15:17:30Z Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells Toscani, Andrés Martin Aguilera, Pablo Nicolás Coluccio Leskow, Federico Mammary Glands Genetics Glándulas Mamarias Genética Epithelial Cells Discoidin Domain Receptor Células Epiteliales Receptor del Dominio Discoidina The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen receptor tyrosine kinases which, together with ErbB2, are involved in many physiological and pathological processes. Here, we investigated the interaction of ErbB2 and DDR1 receptors in breast cancer cells. In contrast to beta1-integrin, DDR1 colocalizes with ErbB2 in membrane clusters regardless of their expression levels. We demonstrated that this spatial coexistence is a consequence of the physical interaction between these receptors. In addition, these receptors are coexpressed in the normal mammary gland but not in breast tumor samples. Together, these results present DDR1 as a novel modulator of the ErbB2/ErbB3 signaling pathway. Instituto de Biotecnología Fil: Toscani, Andrés Martin. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN); Argentina Fil: Toscani, Andrés Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aguilera, Pablo Nicolás. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina Fil: Aguilera, Pablo Nicolás. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Aguilera, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Coluccio Leskow, Federico. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina 2024-02-14T15:04:08Z 2024-02-14T15:04:08Z 2022-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/16601 https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14522 1873-3468 https://doi.org/10.1002/1873-3468.14522 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Wiley FEBS Letters 596 (21) : 2795-2807 (November 2022) |
| spellingShingle | Mammary Glands Genetics Glándulas Mamarias Genética Epithelial Cells Discoidin Domain Receptor Células Epiteliales Receptor del Dominio Discoidina Toscani, Andrés Martin Aguilera, Pablo Nicolás Coluccio Leskow, Federico Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
| title | Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
| title_full | Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
| title_fullStr | Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
| title_full_unstemmed | Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
| title_short | Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells |
| title_sort | discoidin domain receptor 1 regulates erbb2 erbb3 signaling in mammary epithelial cells |
| topic | Mammary Glands Genetics Glándulas Mamarias Genética Epithelial Cells Discoidin Domain Receptor Células Epiteliales Receptor del Dominio Discoidina |
| url | http://hdl.handle.net/20.500.12123/16601 https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14522 https://doi.org/10.1002/1873-3468.14522 |
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