Overview of the role of Shiga toxins in porcine edema disease pathogenesis
Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the a...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Elsevier
2024
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/16529 https://www.sciencedirect.com/science/article/pii/S0041010118301612 https://doi.org/10.1016/j.toxicon.2018.04.019 |
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| author | Casanova, Natalia Andrea Redondo, Leandro Martin Dailoff, Gabriela Cecilia Arenas, David Fernandez Miyakawa, Mariano Enrique |
| author_browse | Arenas, David Casanova, Natalia Andrea Dailoff, Gabriela Cecilia Fernandez Miyakawa, Mariano Enrique Redondo, Leandro Martin |
| author_facet | Casanova, Natalia Andrea Redondo, Leandro Martin Dailoff, Gabriela Cecilia Arenas, David Fernandez Miyakawa, Mariano Enrique |
| author_sort | Casanova, Natalia Andrea |
| collection | INTA Digital |
| description | Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host. Porcine edema disease is a serious affection which can lead to dead causing great losses of weaned piglets. Stx2e is the most frequent Stx variant found in porcine feces and is considered the key virulence factor involved in the pathogenesis of porcine edema disease. Stx2e binds with higher affinity to Gb4 receptor than to Gb3 which could be due to amino acid changes in B subunit. Moreover, this subtype also binds to Forssman glycosphingolipids conferring upon Stx2e a unique promiscuous recognition feature. Manifestations of edema disease are caused by systemic effects of Stx2e with no significant morphologic changes in enterocytes. Endothelial cell necrosis in the brain is an early event in the pathogenesis of ED caused by Stx2e-producing STEC strains. Further studies are needed to generate techniques and tools which allow to understand the circulation and ecology of STEC strains in pigs even in resistant animals for diagnostic and epidemiological purposes. |
| format | Artículo |
| id | INTA16529 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA165292024-01-11T13:43:55Z Overview of the role of Shiga toxins in porcine edema disease pathogenesis Casanova, Natalia Andrea Redondo, Leandro Martin Dailoff, Gabriela Cecilia Arenas, David Fernandez Miyakawa, Mariano Enrique Oedema Pathogenesis Swine Edema Patogénesis Cerdo Shiga Toxin Toxina Shiga Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host. Porcine edema disease is a serious affection which can lead to dead causing great losses of weaned piglets. Stx2e is the most frequent Stx variant found in porcine feces and is considered the key virulence factor involved in the pathogenesis of porcine edema disease. Stx2e binds with higher affinity to Gb4 receptor than to Gb3 which could be due to amino acid changes in B subunit. Moreover, this subtype also binds to Forssman glycosphingolipids conferring upon Stx2e a unique promiscuous recognition feature. Manifestations of edema disease are caused by systemic effects of Stx2e with no significant morphologic changes in enterocytes. Endothelial cell necrosis in the brain is an early event in the pathogenesis of ED caused by Stx2e-producing STEC strains. Further studies are needed to generate techniques and tools which allow to understand the circulation and ecology of STEC strains in pigs even in resistant animals for diagnostic and epidemiological purposes. Instituto de Patobiología Fil: Casanova, Natalia Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Redondo, Leandro Martín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Redondo, Leandro Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Dailoff, Gabriela Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Dailoff, Gabriela Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Arenas, David. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Arenas, David. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica “Houssay”. Laboratorio de Neurofisiopatología; Argentina Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Fernandez Miyakawa, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2024-01-11T13:38:02Z 2024-01-11T13:38:02Z 2018-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/16529 https://www.sciencedirect.com/science/article/pii/S0041010118301612 0041-0101 https://doi.org/10.1016/j.toxicon.2018.04.019 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Toxicon 148 : 149-154 (June 2018) |
| spellingShingle | Oedema Pathogenesis Swine Edema Patogénesis Cerdo Shiga Toxin Toxina Shiga Casanova, Natalia Andrea Redondo, Leandro Martin Dailoff, Gabriela Cecilia Arenas, David Fernandez Miyakawa, Mariano Enrique Overview of the role of Shiga toxins in porcine edema disease pathogenesis |
| title | Overview of the role of Shiga toxins in porcine edema disease pathogenesis |
| title_full | Overview of the role of Shiga toxins in porcine edema disease pathogenesis |
| title_fullStr | Overview of the role of Shiga toxins in porcine edema disease pathogenesis |
| title_full_unstemmed | Overview of the role of Shiga toxins in porcine edema disease pathogenesis |
| title_short | Overview of the role of Shiga toxins in porcine edema disease pathogenesis |
| title_sort | overview of the role of shiga toxins in porcine edema disease pathogenesis |
| topic | Oedema Pathogenesis Swine Edema Patogénesis Cerdo Shiga Toxin Toxina Shiga |
| url | http://hdl.handle.net/20.500.12123/16529 https://www.sciencedirect.com/science/article/pii/S0041010118301612 https://doi.org/10.1016/j.toxicon.2018.04.019 |
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