A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity

Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health and economic burden and is without licensed vaccines or antiviral drugs. The GII.4 HuNoV causes most epidemics worldwide. This virus undergoes epochal evolution with periodic emergence of variants with new anti...

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Main Authors:	Salmen, Wilhelm, Hu, Liya, Bok, Marina, Chaimongkol, Natthawan, Ettayebi, Khalil, Sosnovtsev, Stanislav V., Soni, Kaundal, Ayyar, B. Vijayalakshmi, Shanker, Sreejesh, Neill, Frederick H., Sankaran, Banumathi, Atmar, Robert L., Estes, Mary K., Green, Kim Y., Parreño, Gladys Viviana, Prasad, B. V. Venkataram
Format:	info:ar-repo/semantics/artículo
Language:	Inglés
Published:	Nature Publishing Group 2024
Subjects:	Antigens Nanotechnology Antígenos Nanotecnología Noroviruses Capsid Plasticity Norovirus Plasticidad de la Cápside
Online Access:	http://hdl.handle.net/20.500.12123/16493 https://www.nature.com/articles/s41467-023-42146-0 https://doi.org/10.1038/s41467-023-42146-0