Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America
The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and...
| Main Authors: | , , , , , , , , , , |
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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MDPI
2023
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| Online Access: | http://hdl.handle.net/20.500.12123/16368 https://www.mdpi.com/1999-4915/14/10/2095 https://doi.org/10.3390/v14102095 |
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| author | Marandino, Ana Vagnozzi, Ariel Eduardo Tomás, Gonzalo Techera, Claudia Gerez Miranda, Rocio Del Carmen Hernández, Martín Williman, Joaquín Realpe, Mauricio Greif, Gonzalo Panzera, Yanina Pérez, Ruben |
| author_browse | Gerez Miranda, Rocio Del Carmen Greif, Gonzalo Hernández, Martín Marandino, Ana Panzera, Yanina Pérez, Ruben Realpe, Mauricio Techera, Claudia Tomás, Gonzalo Vagnozzi, Ariel Eduardo Williman, Joaquín |
| author_facet | Marandino, Ana Vagnozzi, Ariel Eduardo Tomás, Gonzalo Techera, Claudia Gerez Miranda, Rocio Del Carmen Hernández, Martín Williman, Joaquín Realpe, Mauricio Greif, Gonzalo Panzera, Yanina Pérez, Ruben |
| author_sort | Marandino, Ana |
| collection | INTA Digital |
| description | The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and the GI-16 is globally distributed. We obtained full-length IBV genomes from Argentine and Uruguayan farms using Illumina sequencing. Genomes of the GI-11 and GI-16 lineages from Argentina and Uruguay differ in part of the spike coding region. The remaining genome regions are similar to the Chinese and Italian strains of the GI-16 lineage that emerged in Asia or Europe in the 1970s. Our findings support that the indigenous GI-11 strains recombine extensively with the invasive GI-16 strains. During the recombination process, GI-11 acquired most of the sequences of the GI-16, retaining the original S1 sequence. GI-11 strains with recombinant genomes are circulating forms that underwent further local evolution. The current IBV scenario in South America includes the GI-16 lineage, recombinant GI-11 strains sharing high similarity with GI-16 outside S1, and Brazilian GI-11 strains with a divergent genomic background. There is also sporadic recombinant in the GI-11 and GI-16 lineages among vaccine and field strains. Our findings exemplified the ability of IBV to generate emergent lineage by using the S gene in different genomic backgrounds. This unique example of recombinational microevolution underscores the genomic plasticity of IBV in South America. |
| format | info:ar-repo/semantics/artículo |
| id | INTA16368 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA163682023-12-27T14:47:57Z Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America Marandino, Ana Vagnozzi, Ariel Eduardo Tomás, Gonzalo Techera, Claudia Gerez Miranda, Rocio Del Carmen Hernández, Martín Williman, Joaquín Realpe, Mauricio Greif, Gonzalo Panzera, Yanina Pérez, Ruben Bronchitis Lineage Recombination Mutation Avian Infectious Bronchitis Virus South America Bronquitis Linaje Recombinación Mutación Virus Bronquitis Infecciosa Aviar América del Sur The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and the GI-16 is globally distributed. We obtained full-length IBV genomes from Argentine and Uruguayan farms using Illumina sequencing. Genomes of the GI-11 and GI-16 lineages from Argentina and Uruguay differ in part of the spike coding region. The remaining genome regions are similar to the Chinese and Italian strains of the GI-16 lineage that emerged in Asia or Europe in the 1970s. Our findings support that the indigenous GI-11 strains recombine extensively with the invasive GI-16 strains. During the recombination process, GI-11 acquired most of the sequences of the GI-16, retaining the original S1 sequence. GI-11 strains with recombinant genomes are circulating forms that underwent further local evolution. The current IBV scenario in South America includes the GI-16 lineage, recombinant GI-11 strains sharing high similarity with GI-16 outside S1, and Brazilian GI-11 strains with a divergent genomic background. There is also sporadic recombinant in the GI-11 and GI-16 lineages among vaccine and field strains. Our findings exemplified the ability of IBV to generate emergent lineage by using the S gene in different genomic backgrounds. This unique example of recombinational microevolution underscores the genomic plasticity of IBV in South America. Instituto de Virología Fil: Marandino, Ana. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Vagnozzi, Ariel Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Tomás, Gonzalo. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Techera, Claudia. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Gerez Miranda, Rocio Del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Hernández, Martín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Williman, Joaquín. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Realpe, Mauricio. Universidad de Guadalajara. Centro Universitario de Ciencias Biológicas y Agropecuarias; México Fil: Greif, Gonzalo. Instituto Pasteur de Montevideo. Unidad de Biología Molecular; Uruguay Fil: Panzera, Yanina. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay Fil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias. Instituto de Biología. Sección Genética Evolutiva; Uruguay 2023-12-27T14:38:15Z 2023-12-27T14:38:15Z 2022-10 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/16368 https://www.mdpi.com/1999-4915/14/10/2095 1999-4915 https://doi.org/10.3390/v14102095 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 14 (10) : 2095 (Octubre 2022) |
| spellingShingle | Bronchitis Lineage Recombination Mutation Avian Infectious Bronchitis Virus South America Bronquitis Linaje Recombinación Mutación Virus Bronquitis Infecciosa Aviar América del Sur Marandino, Ana Vagnozzi, Ariel Eduardo Tomás, Gonzalo Techera, Claudia Gerez Miranda, Rocio Del Carmen Hernández, Martín Williman, Joaquín Realpe, Mauricio Greif, Gonzalo Panzera, Yanina Pérez, Ruben Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America |
| title | Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America |
| title_full | Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America |
| title_fullStr | Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America |
| title_full_unstemmed | Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America |
| title_short | Origin of new lineages by recombination and mutation in avian infectious bronchitis virus from South America |
| title_sort | origin of new lineages by recombination and mutation in avian infectious bronchitis virus from south america |
| topic | Bronchitis Lineage Recombination Mutation Avian Infectious Bronchitis Virus South America Bronquitis Linaje Recombinación Mutación Virus Bronquitis Infecciosa Aviar América del Sur |
| url | http://hdl.handle.net/20.500.12123/16368 https://www.mdpi.com/1999-4915/14/10/2095 https://doi.org/10.3390/v14102095 |
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