Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
Gastrointestinal nematode infections in sheep are a major concern among breeders due to the economic losses they cause in terms of a reduction in both productivity and viability of animals. The situation worsens in face of the emergence of anthelmintic-resistant parasites. In this context, breeding...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | info:ar-repo/semantics/documento de conferencia |
| Language: | Inglés |
| Published: |
FAO
2023
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/16120 |
| _version_ | 1855037429072789504 |
|---|---|
| author | Poli, Mario Andres Caffaro, María Eugenia Cetra, Bibiana Maria Pichler, Rudolf Raschia, Maria Agustina Medus, Pablo Daniel Maizon, Daniel Omar Garcia Podesta, Mario Donzelli, María Valeria Bonelli, Rita Periasamy, Kathiravan |
| author_browse | Bonelli, Rita Caffaro, María Eugenia Cetra, Bibiana Maria Donzelli, María Valeria Garcia Podesta, Mario Maizon, Daniel Omar Medus, Pablo Daniel Periasamy, Kathiravan Pichler, Rudolf Poli, Mario Andres Raschia, Maria Agustina |
| author_facet | Poli, Mario Andres Caffaro, María Eugenia Cetra, Bibiana Maria Pichler, Rudolf Raschia, Maria Agustina Medus, Pablo Daniel Maizon, Daniel Omar Garcia Podesta, Mario Donzelli, María Valeria Bonelli, Rita Periasamy, Kathiravan |
| author_sort | Poli, Mario Andres |
| collection | INTA Digital |
| description | Gastrointestinal nematode infections in sheep are a major concern among breeders due to the economic losses they cause in terms of a reduction in both productivity and viability of animals. The situation worsens in face of the emergence of anthelmintic-resistant parasites. In this context, breeding and management practices aimed at an integrated control of parasites, such as raising parasiteresistant sheep, are required. This study focused on the genetic variation underlying parasite resistance in sheep,
for potential use in breeding programmes. An artificial challenge with infectious H. contortus L3 was carried out in the northeast region of Argentina for more than 10 years in 1 072 Corriedale lambs with an average age of 5.6 months. Body weight, faecal egg count, packed cell volume, and FAMACHA© score were recorded at different time points post-challenge and their heritability and phenotypic and genetic correlations were estimated. Animals were genotyped on 173 single nucleotide polymorphisms
belonging to 77 candidate genes for immune response. The results indicate that there is sufficient genetic variability for the four traits studied, which presented moderate heritabilities (in the range 0.29 to 0.44) and increased along the challenge period, with the exception of the hematocrit, which decreased. Association analyses identified seven markers associated with estimated breeding values for faecal egg count, located in genes involved in different stages of the pathogen-host interaction process. The
information obtained supports the potential of markerassisted breeding schemes to enable profitable and
sustainable sheep production. |
| format | info:ar-repo/semantics/documento de conferencia |
| id | INTA16120 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | FAO |
| publisherStr | FAO |
| record_format | dspace |
| spelling | INTA161202023-12-05T10:35:31Z Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case Poli, Mario Andres Caffaro, María Eugenia Cetra, Bibiana Maria Pichler, Rudolf Raschia, Maria Agustina Medus, Pablo Daniel Maizon, Daniel Omar Garcia Podesta, Mario Donzelli, María Valeria Bonelli, Rita Periasamy, Kathiravan Nematodes Disease Resistance Resilience Candidate Genes Sheep Gastrointestinal Diseases Parasites Nematodos Resistencia a la Enfermedad Resiliencia Genes Candidatos Ovinos Enfermedades Gastrointestinales Parásitos Argentina Raza Corriedale Gastrointestinal nematode infections in sheep are a major concern among breeders due to the economic losses they cause in terms of a reduction in both productivity and viability of animals. The situation worsens in face of the emergence of anthelmintic-resistant parasites. In this context, breeding and management practices aimed at an integrated control of parasites, such as raising parasiteresistant sheep, are required. This study focused on the genetic variation underlying parasite resistance in sheep, for potential use in breeding programmes. An artificial challenge with infectious H. contortus L3 was carried out in the northeast region of Argentina for more than 10 years in 1 072 Corriedale lambs with an average age of 5.6 months. Body weight, faecal egg count, packed cell volume, and FAMACHA© score were recorded at different time points post-challenge and their heritability and phenotypic and genetic correlations were estimated. Animals were genotyped on 173 single nucleotide polymorphisms belonging to 77 candidate genes for immune response. The results indicate that there is sufficient genetic variability for the four traits studied, which presented moderate heritabilities (in the range 0.29 to 0.44) and increased along the challenge period, with the exception of the hematocrit, which decreased. Association analyses identified seven markers associated with estimated breeding values for faecal egg count, located in genes involved in different stages of the pathogen-host interaction process. The information obtained supports the potential of markerassisted breeding schemes to enable profitable and sustainable sheep production. Instituto de Genética Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; Argentina Fil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Cetra, Bibiana Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Medus, Pablo Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; Argentina Fil: Maizon, Daniel Omar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; Argentina Fil: Garcia Podesta, Mario. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; Austria Fil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Bonelli, Rita. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; Argentina Fil: Periasamy, Kathiravan. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; Austria 2023-12-05T10:26:57Z 2023-12-05T10:26:57Z 2023 info:ar-repo/semantics/documento de conferencia info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/16120 978-92-5-137052-0 eng info:eu-repograntAgreement/INTA/2019-PD-E5-I104-001, Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticas info:eu-repograntAgreement/INTA/2019-PE-E6-I114-001, Caracterización de la diversidad genética de plantas, animales y microorganismos mediante herramientas de genómica aplicada info:eu-repograntAgreement/INTA/2019-PE-E6-I145-001, Mejora genética objetiva para aumentar la eficiencia de los sistemas de producción animal info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf FAO International Symposium on Sustainable Animal Production and Health : Current status and way forward, Viena, 28 June to 2 July 2021 |
| spellingShingle | Nematodes Disease Resistance Resilience Candidate Genes Sheep Gastrointestinal Diseases Parasites Nematodos Resistencia a la Enfermedad Resiliencia Genes Candidatos Ovinos Enfermedades Gastrointestinales Parásitos Argentina Raza Corriedale Poli, Mario Andres Caffaro, María Eugenia Cetra, Bibiana Maria Pichler, Rudolf Raschia, Maria Agustina Medus, Pablo Daniel Maizon, Daniel Omar Garcia Podesta, Mario Donzelli, María Valeria Bonelli, Rita Periasamy, Kathiravan Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case |
| title | Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case |
| title_full | Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case |
| title_fullStr | Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case |
| title_full_unstemmed | Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case |
| title_short | Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case |
| title_sort | integrating technologies for the sustainable control of gastrointestinal parasites in sheep the argentinean case |
| topic | Nematodes Disease Resistance Resilience Candidate Genes Sheep Gastrointestinal Diseases Parasites Nematodos Resistencia a la Enfermedad Resiliencia Genes Candidatos Ovinos Enfermedades Gastrointestinales Parásitos Argentina Raza Corriedale |
| url | http://hdl.handle.net/20.500.12123/16120 |
| work_keys_str_mv | AT polimarioandres integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT caffaromariaeugenia integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT cetrabibianamaria integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT pichlerrudolf integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT raschiamariaagustina integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT meduspablodaniel integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT maizondanielomar integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT garciapodestamario integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT donzellimariavaleria integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT bonellirita integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase AT periasamykathiravan integratingtechnologiesforthesustainablecontrolofgastrointestinalparasitesinsheeptheargentineancase |