Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium
In the last decades, infections by several serovars of Salmonella have become relevant worldwide, not only due to their impact on veterinary health and animal production, but also because they may serve as a source of infection for the human population. Pigs can be infected by several Salmonella ser...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste
2023
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/16099 https://revistas.unne.edu.ar/index.php/vet/article/view/7048 https://doi.org/10.30972/vet.3427048 |
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| author | Joaquim, Patricia Estefania Balbiani, Facundo Delgado, Fernando Oscar Redondo, Leandro Martin Cappuccio, Javier Alejandro Chacana, Pablo |
| author_browse | Balbiani, Facundo Cappuccio, Javier Alejandro Chacana, Pablo Delgado, Fernando Oscar Joaquim, Patricia Estefania Redondo, Leandro Martin |
| author_facet | Joaquim, Patricia Estefania Balbiani, Facundo Delgado, Fernando Oscar Redondo, Leandro Martin Cappuccio, Javier Alejandro Chacana, Pablo |
| author_sort | Joaquim, Patricia Estefania |
| collection | INTA Digital |
| description | In the last decades, infections by several serovars of Salmonella have become relevant worldwide, not only due to their impact on veterinary health and animal production, but also because they may serve as a source of infection for the human population. Pigs can be infected by several Salmonella serovars, being S. Typhimurium one of the most frequently isolated worldwide. In this context, the evaluation of strategies to control Salmonella in farms demands the understanding of the pathogenesis of the microorganism. Thus, the objective of this work was to carry out an experimental infection in 50-day-old pigs using a field strain of S. Typhimurium to evaluate the excretion of the microorganism, organs colonization and the development of histological injuries over the 13-day trial period. Disease was successfully reproduced in eight animals, and two clinical patterns were identified. In four animals, a primarily enteric pattern was observed, where the infection was limited to the gastrointestinal tract, while in another four pigs, enteric and systemic infection with variable fecal excretion and invasion of internal organs was observed. These two infectious patterns were accompanied by changes in fecal consistency and reduced daily weight gain or weight loss in the animals. The observation of two different infectious patterns highlights the need to consider the complexity of the pathogenicity of Salmonella Typhimurium infection in pigs. |
| format | Artículo |
| id | INTA16099 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste |
| publisherStr | Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste |
| record_format | dspace |
| spelling | INTA160992023-12-01T18:36:23Z Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium Joaquim, Patricia Estefania Balbiani, Facundo Delgado, Fernando Oscar Redondo, Leandro Martin Cappuccio, Javier Alejandro Chacana, Pablo Salmonella typhimurium Cerdo Infección Experimental Análisis Bacteriológico Histopatología Swine Experimental Infection Bacteriological Analysis Histopathology Serological Analysis Análisis Serológico In the last decades, infections by several serovars of Salmonella have become relevant worldwide, not only due to their impact on veterinary health and animal production, but also because they may serve as a source of infection for the human population. Pigs can be infected by several Salmonella serovars, being S. Typhimurium one of the most frequently isolated worldwide. In this context, the evaluation of strategies to control Salmonella in farms demands the understanding of the pathogenesis of the microorganism. Thus, the objective of this work was to carry out an experimental infection in 50-day-old pigs using a field strain of S. Typhimurium to evaluate the excretion of the microorganism, organs colonization and the development of histological injuries over the 13-day trial period. Disease was successfully reproduced in eight animals, and two clinical patterns were identified. In four animals, a primarily enteric pattern was observed, where the infection was limited to the gastrointestinal tract, while in another four pigs, enteric and systemic infection with variable fecal excretion and invasion of internal organs was observed. These two infectious patterns were accompanied by changes in fecal consistency and reduced daily weight gain or weight loss in the animals. The observation of two different infectious patterns highlights the need to consider the complexity of the pathogenicity of Salmonella Typhimurium infection in pigs. En las últimas décadas las infecciones por diferentes serovariedades de Salmonella han adquirido importancia a nivel mundial, no solo por su impacto en la sanidad y en la producción de los animales, sino también porque estos constituyen una fuente de infección para los humanos. Los cerdos pueden estar infectados o ser portadores de distintas serovariedades con potencial zoonótico, siendo S. Typhimurium una de las más frecuentemente aisladas a nivel mundial. En este contexto, la evaluación de estrategias para el control de Salmonella en granjas exige el conocimiento de la patogenia del microorganismo. El objetivo de este trabajo fue realizar una infección experimental en cerdos de 50 días de edad utilizando una cepa de campo de S. Typhimurium para evaluar la excreción del microorganismo, la colonización de órganos y el desarrollo de lesiones histológicas durante los 13 días del ensayo. Se logró reproducir la enfermedad en ocho animales y se pudo identificar dos cuadros clínicos. En cuatro animales se observó un cuadro principalmente entérico, en el que la infección estuvo limitada al tracto gastrointestinal; mientras que en otros cuatro cerdos se observó infección entérica y sistémica con excreción fecal variable e invasión de órganos internos. Estos dos cuadros infecciosos estuvieron acompañados de cambios en la consistencia de la materia fecal y menor ganancia diaria de peso o adelgazamiento de los animales. La observación de dos cuadros infecciosos diferentes muestra la necesidad de considerar la complejidad de la patogenicidad de la infección por Salmonella Typhimurium en cerdos. Instituto de Patobiología Fil: Joaquim, Patricia Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Joaquim, Patricia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Balbiani, Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Balbiani, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Delgado, Fernando Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Redondo, Leandro Martin. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Redondo, Leandro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina Fil: Cappuccio, Javier Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Chacana, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Chacana, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2023-12-01T18:22:17Z 2023-12-01T18:22:17Z 2023-11 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/16099 https://revistas.unne.edu.ar/index.php/vet/article/view/7048 1669-6840 1668-4834 https://doi.org/10.30972/vet.3427048 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste Revista Veterinaria / Universidad Nacional del Nordeste 34 (2) : 81-90 (Noviembre 2023) |
| spellingShingle | Salmonella typhimurium Cerdo Infección Experimental Análisis Bacteriológico Histopatología Swine Experimental Infection Bacteriological Analysis Histopathology Serological Analysis Análisis Serológico Joaquim, Patricia Estefania Balbiani, Facundo Delgado, Fernando Oscar Redondo, Leandro Martin Cappuccio, Javier Alejandro Chacana, Pablo Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium |
| title | Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium |
| title_full | Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium |
| title_fullStr | Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium |
| title_full_unstemmed | Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium |
| title_short | Bacteriological, serological, and histopathological study of post-weaning piglets experimentally infected with Salmonella Typhimurium = Estudio bacteriológico, serológico e histopatológico de lechones destetados infectados experimentalmente con Salmonella Typhimurium |
| title_sort | bacteriological serological and histopathological study of post weaning piglets experimentally infected with salmonella typhimurium estudio bacteriologico serologico e histopatologico de lechones destetados infectados experimentalmente con salmonella typhimurium |
| topic | Salmonella typhimurium Cerdo Infección Experimental Análisis Bacteriológico Histopatología Swine Experimental Infection Bacteriological Analysis Histopathology Serological Analysis Análisis Serológico |
| url | http://hdl.handle.net/20.500.12123/16099 https://revistas.unne.edu.ar/index.php/vet/article/view/7048 https://doi.org/10.30972/vet.3427048 |
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