Characterization of lesions of nutritional congenital goitre in cattle
There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (...
| Main Authors: | , , , , , , , |
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Elsevier
2023
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/15310 https://www.sciencedirect.com/science/article/pii/S0021997523002591 https://doi.org/10.1016/j.jcpa.2023.08.002 |
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| author | Colque Caro, Luis Adrián Acuña, Francisco Aguirre Castro, Laura Sabrina Avellaneda Cáceres, Agustín Barbeito, Claudio Gustavo Signorini Porchiett, Marcelo Lisandro Moore, Prando Dadin Micheloud, Juan Francisco |
| author_browse | Acuña, Francisco Aguirre Castro, Laura Sabrina Avellaneda Cáceres, Agustín Barbeito, Claudio Gustavo Colque Caro, Luis Adrián Micheloud, Juan Francisco Moore, Prando Dadin Signorini Porchiett, Marcelo Lisandro |
| author_facet | Colque Caro, Luis Adrián Acuña, Francisco Aguirre Castro, Laura Sabrina Avellaneda Cáceres, Agustín Barbeito, Claudio Gustavo Signorini Porchiett, Marcelo Lisandro Moore, Prando Dadin Micheloud, Juan Francisco |
| author_sort | Colque Caro, Luis Adrián |
| collection | INTA Digital |
| description | There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (fetuses [3], stillbirths [3], neonates [4]) born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), mild goitre (G1), moderate goitre (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in the TGW:BW ratio among groups (P <0.05): 0.3 ± 0.1 in G0, 0.5 ± 0.3 in G1, 0.8 ± 0.3 in G2 and 1.3 ± 0.7 in G3. In G0, large homogeneous follicles with eosinophilic colloid were seen. In the groups with lesions (G1, G2 and G3), heterogeneity in follicle shape and size, height and area of thyroid follicular cells, height of thyroid follicular epithelium and PCNA immunolabelling were directly related to histopathological grade, with significant differences among groups (P <0.001), gradually increasing from G1 to G3 compared with G0. The TGW:BW ratio and histological grade were positively correlated (P = 0.008). |
| format | info:ar-repo/semantics/artículo |
| id | INTA15310 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA153102025-07-17T13:02:14Z Characterization of lesions of nutritional congenital goitre in cattle Colque Caro, Luis Adrián Acuña, Francisco Aguirre Castro, Laura Sabrina Avellaneda Cáceres, Agustín Barbeito, Claudio Gustavo Signorini Porchiett, Marcelo Lisandro Moore, Prando Dadin Micheloud, Juan Francisco Hyperplasia Hypertrophy Thyroid Gland Cattle Hiperplasia Hipertrofia Ganado Bovino Glándula Tiroide Morphometry Perinatal Deaths Thyroid Tiroides There are few studies that classify and characterize the morphometric and immunohistochemical features of goitre in bovine thyroid glands (TGs). We investigated 39 bovine TGs (fetuses [9], stillbirths [18], neonates [12]) born to dams with low T4 hormone levels and no iodine supplementation and 10 (fetuses [3], stillbirths [3], neonates [4]) born to dams with normal T4 levels and supplemented with iodine. Body weight (BW), TG weight (TGW), TGW:BW ratio and histological lesions were determined. The TGs were classified histopathologically as normal gland (G0), mild goitre (G1), moderate goitre (G2) or severe goitre (G3). Various morphological and morphometric parameters were calculated from microscopic images using image analysis software. Immunohistochemistry was performed to detect proliferating cell nuclear antigen (PCNA). There were significant differences in the TGW:BW ratio among groups (P <0.05): 0.3 ± 0.1 in G0, 0.5 ± 0.3 in G1, 0.8 ± 0.3 in G2 and 1.3 ± 0.7 in G3. In G0, large homogeneous follicles with eosinophilic colloid were seen. In the groups with lesions (G1, G2 and G3), heterogeneity in follicle shape and size, height and area of thyroid follicular cells, height of thyroid follicular epithelium and PCNA immunolabelling were directly related to histopathological grade, with significant differences among groups (P <0.001), gradually increasing from G1 to G3 compared with G0. The TGW:BW ratio and histological grade were positively correlated (P = 0.008). Instituto de Investigación Animal del Chaco Semiárido Fil: Colque Caro, Luis Adrián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina Fil: Colque Caro, Luis Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina Fil: Acuña, Francisco. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada; Argentina Fil: Acuña, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; Argentina Fil: Aguirre Castro, Laura Sabrina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina Fil: Aguirre Castro, Laura Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina Fil: Avellaneda Cáceres, Agustín. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina Fil: Avellaneda Cáceres, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina Fil: Barbeito, Claudio G.Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Experimental y Comparada. Laboratorio de Histología y Embriología Descriptiva; Argentina Fil: Barbeito, Claudio G. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT La Plata; Argentina Fil: Signorini Porchiett, Marcelo Lisandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Signorini Porchiett, Marcelo Lisandro.Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea; Argentina Fil: Moore, Prando Dadin. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Moore, Prando Dadin. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina Fil: Micheloud, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. CCT Salta - Jujuy; Argentina Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Agrarias y Veterinarias; Argentina 2023-09-26T10:48:02Z 2023-09-26T10:48:02Z 2023-08-18 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/15310 https://www.sciencedirect.com/science/article/pii/S0021997523002591 0021-9975 1532-3129 (online) https://doi.org/10.1016/j.jcpa.2023.08.002 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Journal of Comparative Pathology 206 : 1-8 (October 2023) |
| spellingShingle | Hyperplasia Hypertrophy Thyroid Gland Cattle Hiperplasia Hipertrofia Ganado Bovino Glándula Tiroide Morphometry Perinatal Deaths Thyroid Tiroides Colque Caro, Luis Adrián Acuña, Francisco Aguirre Castro, Laura Sabrina Avellaneda Cáceres, Agustín Barbeito, Claudio Gustavo Signorini Porchiett, Marcelo Lisandro Moore, Prando Dadin Micheloud, Juan Francisco Characterization of lesions of nutritional congenital goitre in cattle |
| title | Characterization of lesions of nutritional congenital goitre in cattle |
| title_full | Characterization of lesions of nutritional congenital goitre in cattle |
| title_fullStr | Characterization of lesions of nutritional congenital goitre in cattle |
| title_full_unstemmed | Characterization of lesions of nutritional congenital goitre in cattle |
| title_short | Characterization of lesions of nutritional congenital goitre in cattle |
| title_sort | characterization of lesions of nutritional congenital goitre in cattle |
| topic | Hyperplasia Hypertrophy Thyroid Gland Cattle Hiperplasia Hipertrofia Ganado Bovino Glándula Tiroide Morphometry Perinatal Deaths Thyroid Tiroides |
| url | http://hdl.handle.net/20.500.12123/15310 https://www.sciencedirect.com/science/article/pii/S0021997523002591 https://doi.org/10.1016/j.jcpa.2023.08.002 |
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