Degrade to survive : the intricate world of piroplasmid proteases
Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, h...
| Main Authors: | , , , , , |
|---|---|
| Format: | Artículo |
| Language: | Inglés |
| Published: |
Elsevier
2023
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/15219 https://www.sciencedirect.com/science/article/pii/S1471492223001186 https://doi.org/10.1016/j.pt.2023.04.010 |
| _version_ | 1855485519206547456 |
|---|---|
| author | Florin-Christensen, Mónica Sojka, Daniel Ganzinelli, Sabrina Belen Snebergerová, Pavla Suarez, Carlos Esteban Schnittger, Leonhard |
| author_browse | Florin-Christensen, Mónica Ganzinelli, Sabrina Belen Schnittger, Leonhard Snebergerová, Pavla Sojka, Daniel Suarez, Carlos Esteban |
| author_facet | Florin-Christensen, Mónica Sojka, Daniel Ganzinelli, Sabrina Belen Snebergerová, Pavla Suarez, Carlos Esteban Schnittger, Leonhard |
| author_sort | Florin-Christensen, Mónica |
| collection | INTA Digital |
| description | Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens. |
| format | Artículo |
| id | INTA15219 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA152192023-09-15T10:26:44Z Degrade to survive : the intricate world of piroplasmid proteases Florin-Christensen, Mónica Sojka, Daniel Ganzinelli, Sabrina Belen Snebergerová, Pavla Suarez, Carlos Esteban Schnittger, Leonhard Babesia Theileria Peptidases Vaccines Peptidasas Vacuna Piroplasmids Degradome Piroplásmidos Degradoma Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens. Instituto de Patobiología Fil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Florin-Christensen, Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Sojka, Daniel. Academy of Sciences of the Czech Republic. Institute of Parasitology; República Checa Fil: Ganzinelli Sabrina Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Ganzinelli Sabrina Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Snebergerová, Pavla. Academy of Sciences of the Czech Republic. Institute of Parasitology; República Checa Fil: Snebergerová, Pavla. University of South Bohemia. Faculty of Science; República Checa Fil: Suarez, Carlos Esteban. United States Department of Agricultural-Agricultural Research Service. Animal Disease Research Unit; Estados Unidos Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2023-09-15T10:19:06Z 2023-09-15T10:19:06Z 2023-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/15219 https://www.sciencedirect.com/science/article/pii/S1471492223001186 1471-5007 https://doi.org/10.1016/j.pt.2023.04.010 eng info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001, Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública info:eu-repograntAgreement/INTA/2019-PD-E5-I105-001, Patógenos animales: su interacción con el hospedador y el medio ambiente. Impacto en productividad, ecosistemas, sanidad animal y salud pública en el marco ?Una Salud? info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Trends in Parasitology 39 (7) : 532-546 (July 2023) |
| spellingShingle | Babesia Theileria Peptidases Vaccines Peptidasas Vacuna Piroplasmids Degradome Piroplásmidos Degradoma Florin-Christensen, Mónica Sojka, Daniel Ganzinelli, Sabrina Belen Snebergerová, Pavla Suarez, Carlos Esteban Schnittger, Leonhard Degrade to survive : the intricate world of piroplasmid proteases |
| title | Degrade to survive : the intricate world of piroplasmid proteases |
| title_full | Degrade to survive : the intricate world of piroplasmid proteases |
| title_fullStr | Degrade to survive : the intricate world of piroplasmid proteases |
| title_full_unstemmed | Degrade to survive : the intricate world of piroplasmid proteases |
| title_short | Degrade to survive : the intricate world of piroplasmid proteases |
| title_sort | degrade to survive the intricate world of piroplasmid proteases |
| topic | Babesia Theileria Peptidases Vaccines Peptidasas Vacuna Piroplasmids Degradome Piroplásmidos Degradoma |
| url | http://hdl.handle.net/20.500.12123/15219 https://www.sciencedirect.com/science/article/pii/S1471492223001186 https://doi.org/10.1016/j.pt.2023.04.010 |
| work_keys_str_mv | AT florinchristensenmonica degradetosurvivetheintricateworldofpiroplasmidproteases AT sojkadaniel degradetosurvivetheintricateworldofpiroplasmidproteases AT ganzinellisabrinabelen degradetosurvivetheintricateworldofpiroplasmidproteases AT snebergerovapavla degradetosurvivetheintricateworldofpiroplasmidproteases AT suarezcarlosesteban degradetosurvivetheintricateworldofpiroplasmidproteases AT schnittgerleonhard degradetosurvivetheintricateworldofpiroplasmidproteases |