Combined live oral priming and intramuscular boosting regimen with Rotarix® and a nanoparticle-based trivalent rotavirus vaccine evaluated in gnotobiotic pig models of G4P[6] and G1P[8] human rotavirus infection

Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income countries where vaccine efficacy is the lowest due to chronic malnutrition, gut...

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Main Authors:	Hensley, Casey, Nyblade, Charlotte, Zhou, Peng, Parreño, Gladys Viviana, Ramesh, Ashwin, Frazier, Annie, Frazier, Maggie, Garrison, Sarah, Fantasia-Davis, Ariana, Cai, Ruiqing, Huang, Peng-Wei, Xia, Ming, Tan, Ming, Yuan, Lijuan
Format:	info:ar-repo/semantics/artículo
Language:	Inglés
Published:	MDPI 2023
Subjects:	Rotavirus Nanoparticles Gnotobiotic Animals Swine Vaccines Nanopartículas Animales Notobióticos Cerdo Vacuna Human Rotavirus Infection Infección por Rotavirus Humano
Online Access:	http://hdl.handle.net/20.500.12123/15201 https://www.mdpi.com/2076-393X/11/5/927 https://doi.org/10.3390/vaccines11050927