Genetic resistance to gastrointestinal parasites in sheep
Gastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally based on the use of anthelmintic drugs. However, continuous, extensive, a...
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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CAB International
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/15198 https://www.cabidigitallibrary.org/doi/10.1079/cabireviews.2023.0019 https://doi.org/10.1079/cabireviews.2023.0019 |
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| author | Poli, Mario Andres Donzelli, María Valeria Caffaro, María Eugenia Raschia, Maria Agustina Papaleo Mazzucco, Juliana Rossi, Ursula Amaranta |
| author_browse | Caffaro, María Eugenia Donzelli, María Valeria Papaleo Mazzucco, Juliana Poli, Mario Andres Raschia, Maria Agustina Rossi, Ursula Amaranta |
| author_facet | Poli, Mario Andres Donzelli, María Valeria Caffaro, María Eugenia Raschia, Maria Agustina Papaleo Mazzucco, Juliana Rossi, Ursula Amaranta |
| author_sort | Poli, Mario Andres |
| collection | INTA Digital |
| description | Gastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally based on the use of anthelmintic drugs. However, continuous, extensive, and indiscriminate use of these drugs has led to the emergence and spread of strains of parasites resistant to the major chemical compounds used. This situation has led to considering alternative strategies for worm control. One of them is the selection of individuals for greater resistance to GINs. A number of phenotypic traits have been reported in the bibliography, including parasitological, biochemical, hematological, and immunological traits, but fecal egg count (FEC) is considered the primary and most practical measure of resistance. Genomic studies have reported polymorphisms associated with GIN resistance traits on almost all sheep chromosomes. Among other loci, FEC has been associated with the major histocompatibility complex (MHC) through quantitative trait loci (QTL) analysis and genome-wide association studies (GWAS). This review covers the principal aspects reported in the literature on several parameters considered to evaluate the resistance status of sheep to nematodes, mainly Haemonchus contortus, the correlation between resistance markers with economically important production traits, and the main genomic regions identified as relevant in determining the phenotype for resistance or susceptibility to GINs. |
| format | info:ar-repo/semantics/artículo |
| id | INTA15198 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | CAB International |
| publisherStr | CAB International |
| record_format | dspace |
| spelling | INTA151982023-09-13T13:11:39Z Genetic resistance to gastrointestinal parasites in sheep Poli, Mario Andres Donzelli, María Valeria Caffaro, María Eugenia Raschia, Maria Agustina Papaleo Mazzucco, Juliana Rossi, Ursula Amaranta Nematodes Resistencia Genética Genes Candidatos Sistema mhc Respuesta Inmunológica Ovinos Enfermedades Gastrointestinales Genetic Resistance Candidate Genes Major Histocompatibility Complex Immune Response Sheep Gastrointestinal Diseases Gastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally based on the use of anthelmintic drugs. However, continuous, extensive, and indiscriminate use of these drugs has led to the emergence and spread of strains of parasites resistant to the major chemical compounds used. This situation has led to considering alternative strategies for worm control. One of them is the selection of individuals for greater resistance to GINs. A number of phenotypic traits have been reported in the bibliography, including parasitological, biochemical, hematological, and immunological traits, but fecal egg count (FEC) is considered the primary and most practical measure of resistance. Genomic studies have reported polymorphisms associated with GIN resistance traits on almost all sheep chromosomes. Among other loci, FEC has been associated with the major histocompatibility complex (MHC) through quantitative trait loci (QTL) analysis and genome-wide association studies (GWAS). This review covers the principal aspects reported in the literature on several parameters considered to evaluate the resistance status of sheep to nematodes, mainly Haemonchus contortus, the correlation between resistance markers with economically important production traits, and the main genomic regions identified as relevant in determining the phenotype for resistance or susceptibility to GINs. Instituto de Genética Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; Argentina Fil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Donzelli, María Valeria. Universidad Nacional de Lomas de Zamora. Facultad de Ciencias Agrarias; Argentina Fil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina Fil: Raschia, Maria Agustina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina Fil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina 2023-09-13T13:02:56Z 2023-09-13T13:02:56Z 2023-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/15198 https://www.cabidigitallibrary.org/doi/10.1079/cabireviews.2023.0019 1749-8848 https://doi.org/10.1079/cabireviews.2023.0019 eng info:eu-repograntAgreement/INTA/2019-PD-E5-I104-001, Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticas info:eu-repograntAgreement/INTA/2019-PE-E6-I114-001, Caracterización de la diversidad genética de plantas, animales y microorganismos mediante herramientas de genómica aplicada. info:eu-repograntAgreement/INTA/2019-PE-E6-I145-001, Mejora genética objetiva para aumentar la eficiencia de los sistemas de producción animal. info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf CAB International CABI Reviews 18 : 1 (Junio 2023) |
| spellingShingle | Nematodes Resistencia Genética Genes Candidatos Sistema mhc Respuesta Inmunológica Ovinos Enfermedades Gastrointestinales Genetic Resistance Candidate Genes Major Histocompatibility Complex Immune Response Sheep Gastrointestinal Diseases Poli, Mario Andres Donzelli, María Valeria Caffaro, María Eugenia Raschia, Maria Agustina Papaleo Mazzucco, Juliana Rossi, Ursula Amaranta Genetic resistance to gastrointestinal parasites in sheep |
| title | Genetic resistance to gastrointestinal parasites in sheep |
| title_full | Genetic resistance to gastrointestinal parasites in sheep |
| title_fullStr | Genetic resistance to gastrointestinal parasites in sheep |
| title_full_unstemmed | Genetic resistance to gastrointestinal parasites in sheep |
| title_short | Genetic resistance to gastrointestinal parasites in sheep |
| title_sort | genetic resistance to gastrointestinal parasites in sheep |
| topic | Nematodes Resistencia Genética Genes Candidatos Sistema mhc Respuesta Inmunológica Ovinos Enfermedades Gastrointestinales Genetic Resistance Candidate Genes Major Histocompatibility Complex Immune Response Sheep Gastrointestinal Diseases |
| url | http://hdl.handle.net/20.500.12123/15198 https://www.cabidigitallibrary.org/doi/10.1079/cabireviews.2023.0019 https://doi.org/10.1079/cabireviews.2023.0019 |
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