Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina
An outbreak of α-mannosidosis in a bovine herd from Buenos Aires province is reported. Postmortem examination, histology, lectin histochemistry and electron microscopy were performed on five calves born with nervous signs. Hair samples from dams and calves were genetically analysed. The α-mannosidas...
| Autores principales: | , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/15008 https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vrc2.687 https://doi.org/10.1002/vrc2.687 |
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| author | Morris, Winston Eduardo Delgado, Fernando Oscar Micheloud, Juan Francisco Garro, Carlos Javier Olguin Perglione, Cecilia Ebinger, Marem Gimeno, Eduardo Juan Garbaccio, Sergio Gabriel Vilte, Daniel Alejandro |
| author_browse | Delgado, Fernando Oscar Ebinger, Marem Garbaccio, Sergio Gabriel Garro, Carlos Javier Gimeno, Eduardo Juan Micheloud, Juan Francisco Morris, Winston Eduardo Olguin Perglione, Cecilia Vilte, Daniel Alejandro |
| author_facet | Morris, Winston Eduardo Delgado, Fernando Oscar Micheloud, Juan Francisco Garro, Carlos Javier Olguin Perglione, Cecilia Ebinger, Marem Gimeno, Eduardo Juan Garbaccio, Sergio Gabriel Vilte, Daniel Alejandro |
| author_sort | Morris, Winston Eduardo |
| collection | INTA Digital |
| description | An outbreak of α-mannosidosis in a bovine herd from Buenos Aires province is reported. Postmortem examination, histology, lectin histochemistry and electron microscopy were performed on five calves born with nervous signs. Hair samples from dams and calves were genetically analysed. The α-mannosidase gene including exon 7 was amplified and sequenced. At postmortem examination, no gross changes were evident. Histologically, cytoplasmic neuronal vacuolation in the brain and cerebellum of the five calves, staining moderately to intensively, with lectin histochemistry was evident. Ultrastructurally, vacuoles containing finely granulated material in the cytoplasm of neurons, myelin degeneration and axonal swelling were seen in the brain. Genetic analysis revealed a heterozygous carrier state for 961T→C transition in the exon 7 of α-mannosidosis gene of four cows, and a recessive homozygous state for 961T→C transition in the same genes in the calves analysed. This highlights the importance of identifying and removing animals carrying the α-mannosidosis mutated gene. |
| format | Artículo |
| id | INTA15008 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA150082023-08-24T17:19:07Z Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina Morris, Winston Eduardo Delgado, Fernando Oscar Micheloud, Juan Francisco Garro, Carlos Javier Olguin Perglione, Cecilia Ebinger, Marem Gimeno, Eduardo Juan Garbaccio, Sergio Gabriel Vilte, Daniel Alejandro Ganado Bovino Razas (animales) Enfermedades de los Animales Argentina Cattle Breeds (animals) Animal Diseases Raza Aberdeen Angus An outbreak of α-mannosidosis in a bovine herd from Buenos Aires province is reported. Postmortem examination, histology, lectin histochemistry and electron microscopy were performed on five calves born with nervous signs. Hair samples from dams and calves were genetically analysed. The α-mannosidase gene including exon 7 was amplified and sequenced. At postmortem examination, no gross changes were evident. Histologically, cytoplasmic neuronal vacuolation in the brain and cerebellum of the five calves, staining moderately to intensively, with lectin histochemistry was evident. Ultrastructurally, vacuoles containing finely granulated material in the cytoplasm of neurons, myelin degeneration and axonal swelling were seen in the brain. Genetic analysis revealed a heterozygous carrier state for 961T→C transition in the exon 7 of α-mannosidosis gene of four cows, and a recessive homozygous state for 961T→C transition in the same genes in the calves analysed. This highlights the importance of identifying and removing animals carrying the α-mannosidosis mutated gene. EEA Mercedes Fil: Morris, Winston Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Mercedes; Argentina Fil: Delgado, Fernando Oscar. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Salta; Argentina. Fil: Garro, Carlos Javier. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Olguin Perglione, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina Fil: Ebinger, Maren. Actividad privada; Argentina Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata; Argentina Fil: Garbaccio, Sergio Gabriel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina Fil: Vilte, Daniel Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina 2023-08-24T17:11:55Z 2023-08-24T17:11:55Z 2023-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/15008 https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vrc2.687 2052-6121 https://doi.org/10.1002/vrc2.687 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Argentina .......... (nation) (World, South America) 7006477 Wiley Vet Record Case Reports : e687 (2023) |
| spellingShingle | Ganado Bovino Razas (animales) Enfermedades de los Animales Argentina Cattle Breeds (animals) Animal Diseases Raza Aberdeen Angus Morris, Winston Eduardo Delgado, Fernando Oscar Micheloud, Juan Francisco Garro, Carlos Javier Olguin Perglione, Cecilia Ebinger, Marem Gimeno, Eduardo Juan Garbaccio, Sergio Gabriel Vilte, Daniel Alejandro Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina |
| title | Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina |
| title_full | Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina |
| title_fullStr | Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina |
| title_full_unstemmed | Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina |
| title_short | Bovine autosomal recessive alpha-mannosidosis in an Aberdeen Angus herd from Argentina |
| title_sort | bovine autosomal recessive alpha mannosidosis in an aberdeen angus herd from argentina |
| topic | Ganado Bovino Razas (animales) Enfermedades de los Animales Argentina Cattle Breeds (animals) Animal Diseases Raza Aberdeen Angus |
| url | http://hdl.handle.net/20.500.12123/15008 https://bvajournals.onlinelibrary.wiley.com/doi/10.1002/vrc2.687 https://doi.org/10.1002/vrc2.687 |
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