Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis
Abuse and misuse of antimicrobial agents has accelerated the spread of antimicrobial-resistant bacteria. The association between antimicrobial-resistant infections in humans and antimicrobial use in agriculture is complex, but well-documented. This study provides a systematic review and meta-analysi...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Elsevier
2023
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| Online Access: | http://hdl.handle.net/20.500.12123/14893 https://www.sciencedirect.com/science/article/pii/S032575412200058X https://doi.org/10.1016/j.ram.2022.07.001 |
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| author | Prack McCormick, Barbara Quiroga, María P. Alvarez, Veronica E. Centrón, Daniela Tittonell, Pablo Adrian |
| author_browse | Alvarez, Veronica E. Centrón, Daniela Prack McCormick, Barbara Quiroga, María P. Tittonell, Pablo Adrian |
| author_facet | Prack McCormick, Barbara Quiroga, María P. Alvarez, Veronica E. Centrón, Daniela Tittonell, Pablo Adrian |
| author_sort | Prack McCormick, Barbara |
| collection | INTA Digital |
| description | Abuse and misuse of antimicrobial agents has accelerated the spread of antimicrobial-resistant bacteria. The association between antimicrobial-resistant infections in humans and antimicrobial use in agriculture is complex, but well-documented. This study provides a systematic review and meta-analysis of the dissemination of antimicrobial resistance (AMR) to antimicrobials defined as critically important by the WHO, in swine, chicken, and cattle from intensive and extensive production systems in Argentina. We conducted searches in electronic databases (MEDLINE-PubMed, Web of Science, SciELO, the National System of Digital Repositories from Argentina) as well as in the gray literature. Inclusion criteria were epidemiological studies on AMR in the main food-transmitted bacteria, Salmonella spp., Campylobacter spp., Escherichia coli and Enterococcus spp., and mastitis-causing bacteria, isolated from swine, chicken, dairy and beef cattle from Argentina. This study gives evidence for supporting the hypothesis that AMR of common food-transmitted bacteria in Argentina is reaching alarming levels. Meta-analyses followed by subgroup analyses confirmed the association between the prevalence of AMR and (a) animal species (p<0.01) for streptomycin, ampicillin and tetracycline or (b) the animal production system (p<0.05) for streptomycin, cefotaxime, nalidixic acid, ampicillin and tetracycline. Moreover, swine (0.47 [0.29; 0.66]) and intensive production (0.62 [0.34; 0.83]) showed the highest pooled prevalence of multidrug resistance while dairy (0.056 [0.003; 0.524]) and extensive production (0.107 [0.043; 0.240]) showed the lowest. A research gap regarding beef-cattle from feedlot was identified. Finally, there is an urgent need for political measures meant to coordinate and harmonize AMR surveillance and regulate antimicrobial use in animal production. |
| format | info:ar-repo/semantics/artículo |
| id | INTA14893 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA148932023-08-09T15:47:58Z Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis Prack McCormick, Barbara Quiroga, María P. Alvarez, Veronica E. Centrón, Daniela Tittonell, Pablo Adrian Resistencia a Medicamentos Antimicrobianos Sistemas de Explotación Ganadería Ganado Drug Resistance Antimicrobials Farming Systems Animal Husbandry Livestock Abuse and misuse of antimicrobial agents has accelerated the spread of antimicrobial-resistant bacteria. The association between antimicrobial-resistant infections in humans and antimicrobial use in agriculture is complex, but well-documented. This study provides a systematic review and meta-analysis of the dissemination of antimicrobial resistance (AMR) to antimicrobials defined as critically important by the WHO, in swine, chicken, and cattle from intensive and extensive production systems in Argentina. We conducted searches in electronic databases (MEDLINE-PubMed, Web of Science, SciELO, the National System of Digital Repositories from Argentina) as well as in the gray literature. Inclusion criteria were epidemiological studies on AMR in the main food-transmitted bacteria, Salmonella spp., Campylobacter spp., Escherichia coli and Enterococcus spp., and mastitis-causing bacteria, isolated from swine, chicken, dairy and beef cattle from Argentina. This study gives evidence for supporting the hypothesis that AMR of common food-transmitted bacteria in Argentina is reaching alarming levels. Meta-analyses followed by subgroup analyses confirmed the association between the prevalence of AMR and (a) animal species (p<0.01) for streptomycin, ampicillin and tetracycline or (b) the animal production system (p<0.05) for streptomycin, cefotaxime, nalidixic acid, ampicillin and tetracycline. Moreover, swine (0.47 [0.29; 0.66]) and intensive production (0.62 [0.34; 0.83]) showed the highest pooled prevalence of multidrug resistance while dairy (0.056 [0.003; 0.524]) and extensive production (0.107 [0.043; 0.240]) showed the lowest. A research gap regarding beef-cattle from feedlot was identified. Finally, there is an urgent need for political measures meant to coordinate and harmonize AMR surveillance and regulate antimicrobial use in animal production. El abuso y mal uso de los antimicrobianos aceleró la propagación de bacterias resistentes. La asociación entre las infecciones que presentan resistencia a antimicrobianos (RAM) en humanos y el uso de antimicrobianos en la producción agropecuaria es compleja, pero está bien documentada. Proporcionamos una revisión sistemática y metaanálisis sobre la diseminación de la resistencia a antimicrobianos designados como críticamente importantes por la Organización Mundial de la Salud (OMS) en cerdos, aves y bovinos de producción intensiva y extensiva en Argentina. Se buscó información en bases de datos electrónicas (Medline-PubMed, Web of Science, SciELO, Sistema Nacional de Repositorios Digitales de Argentina) y en la literatura gris. Se incluyeron estudios epidemiológicos sobre la RAM en las principales bacterias transmitidas por los alimentos – Salmonella spp., Campylobacter spp., Escherichia coli y Enterococcus spp. – y bacterias causantes de mastitis aisladas de cerdos, pollos y bovinos. Los resultados de este estudio apoyan la hipótesis de que la RAM de las bacterias transmitidas por los alimentos alcanza niveles alarmantes. Los metaanálisis seguidos de análisis por subgrupos mostraron asociación entre la RAM y (a) el animal (p < 0,01) para estreptomicina, ampicilina y tetraciclina o (b) el sistema productivo (p < 0,05) para estreptomicina, cefotaxima, ampicilina, ácido nalidíxico y tetraciclina. La mayor prevalencia conjunta de multirresistencia se detectó en cerdos (0,47 [0,29; 0,66]) y producción intensiva (0,62 [0,34; 0,83]), mientras que la menor correspondió a bovinos de leche (0,056 [0,003; 0,524]) y producción extensiva (0,107 [0,043; 0,240]). Se observó un vacío de información respecto de los bovinos de feedlot. Es urgente adoptar medidas políticas para coordinar y armonizar la vigilancia de la RAM y regular el uso de antimicrobianos en animales. EEA Bariloche Fil: Prack McCormick, Barbara. Universidad Nacional de Lomas de Zamora; Argentina Fil: Quiroga, Maria P. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica. Laboratorio de Investigaciones en Mecanismos de Resistencia a Antibióticos; Argentina. Fil: Quiroga, Maria P. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Microbiología y Parasitología Médica. Laboratorio de Investigaciones en Mecanismos de Resistencia a Antibióticos; Argentina. Fil: Alvarez, Veronica E. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica. Laboratorio de Investigaciones en Mecanismos de Resistencia a Antibióticos; Argentina. Fil: Alvarez, Veronica E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Microbiología y Parasitología Médica. Laboratorio de Investigaciones en Mecanismos de Resistencia a Antibióticos; Argentina. Fil: Tittonell, Pablo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina Fil: Tittonell, Pablo Adrian. Groningen University. Institute of Evolutionary Life Science; Países Bajos. 2023-08-09T15:26:45Z 2023-08-09T15:26:45Z 2023-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/20.500.12123/14893 https://www.sciencedirect.com/science/article/pii/S032575412200058X 0325-7541 0325-1713 https://doi.org/10.1016/j.ram.2022.07.001 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Revista Argentina de Microbiología 55 (1) : 25-42. (January–March 2023) |
| spellingShingle | Resistencia a Medicamentos Antimicrobianos Sistemas de Explotación Ganadería Ganado Drug Resistance Antimicrobials Farming Systems Animal Husbandry Livestock Prack McCormick, Barbara Quiroga, María P. Alvarez, Veronica E. Centrón, Daniela Tittonell, Pablo Adrian Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis |
| title | Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis |
| title_full | Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis |
| title_fullStr | Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis |
| title_full_unstemmed | Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis |
| title_short | Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis |
| title_sort | antimicrobial resistance dissemination associated with intensive animal production practices in argentina a systematic review and meta analysis |
| topic | Resistencia a Medicamentos Antimicrobianos Sistemas de Explotación Ganadería Ganado Drug Resistance Antimicrobials Farming Systems Animal Husbandry Livestock |
| url | http://hdl.handle.net/20.500.12123/14893 https://www.sciencedirect.com/science/article/pii/S032575412200058X https://doi.org/10.1016/j.ram.2022.07.001 |
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