Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations
Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for...
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Facultad de Ciencias Veterinarias, Universidad Austral de Chile
2023
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/14799 http://revistas.uach.cl/index.php/australjvs/article/view/2961 https://doi.org/10.4067/S0719-81322018000200101 |
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| author | Auad, Jordana Cerutti, Julieta Cooper, Laura Gabriela Camussone, Cecilia Lozano, Natalia A. Crespo, Francisco M. Lozano, Alejandro |
| author_browse | Auad, Jordana Camussone, Cecilia Cerutti, Julieta Cooper, Laura Gabriela Crespo, Francisco M. Lozano, Alejandro Lozano, Natalia A. |
| author_facet | Auad, Jordana Cerutti, Julieta Cooper, Laura Gabriela Camussone, Cecilia Lozano, Natalia A. Crespo, Francisco M. Lozano, Alejandro |
| author_sort | Auad, Jordana |
| collection | INTA Digital |
| description | Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected. |
| format | info:ar-repo/semantics/artículo |
| id | INTA14799 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Facultad de Ciencias Veterinarias, Universidad Austral de Chile |
| publisherStr | Facultad de Ciencias Veterinarias, Universidad Austral de Chile |
| record_format | dspace |
| spelling | INTA147992023-07-21T14:23:58Z Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations Auad, Jordana Cerutti, Julieta Cooper, Laura Gabriela Camussone, Cecilia Lozano, Natalia A. Crespo, Francisco M. Lozano, Alejandro Corynebacterium pseudotuberculosis Goats Immune Response Pregnancy Bacterins Immunoglobulins Caseous Lymphadenitis Caprinos Respuesta Inmunológica Gestación Bacterinas Inmunoglobulina Linfoadenitis Caseosa Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected. EEA Rafaela Fil: Auad, Jordana. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina Fil: Cerutti, Julieta. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina Fil: Cooper, Laura Gabriela. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina Fil: Camussone, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina Fil: Camussone, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Lozano, Natalia A. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; Argentina Fil: Crespo, Francisco M.. Establecimiento Los Talas. Potrero de Garay, Córdoba; Argentina Fil: Lozano, Alejandro. Universidad Católica de Córdoba. Hospital Veterinario. Laboratorio de Inmunología; Argentina Fil: Lozano, Alejandro. Universidad Católica de Córdoba. Facultad de Medicina. Cátedra de Inmunología; Argentina 2023-07-21T14:18:43Z 2023-07-21T14:18:43Z 2018 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/14799 http://revistas.uach.cl/index.php/australjvs/article/view/2961 0719-8000 0719-8132 https://doi.org/10.4067/S0719-81322018000200101 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Facultad de Ciencias Veterinarias, Universidad Austral de Chile Austral Journal of Veterinary Sciences 50 (2) : 101–105. (2018) |
| spellingShingle | Corynebacterium pseudotuberculosis Goats Immune Response Pregnancy Bacterins Immunoglobulins Caseous Lymphadenitis Caprinos Respuesta Inmunológica Gestación Bacterinas Inmunoglobulina Linfoadenitis Caseosa Auad, Jordana Cerutti, Julieta Cooper, Laura Gabriela Camussone, Cecilia Lozano, Natalia A. Crespo, Francisco M. Lozano, Alejandro Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations |
| title | Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations |
| title_full | Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations |
| title_fullStr | Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations |
| title_full_unstemmed | Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations |
| title_short | Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations |
| title_sort | humoral immune response of pregnant goats to two corynebacterium pseudotuberculosis bacterin formulations |
| topic | Corynebacterium pseudotuberculosis Goats Immune Response Pregnancy Bacterins Immunoglobulins Caseous Lymphadenitis Caprinos Respuesta Inmunológica Gestación Bacterinas Inmunoglobulina Linfoadenitis Caseosa |
| url | http://hdl.handle.net/20.500.12123/14799 http://revistas.uach.cl/index.php/australjvs/article/view/2961 https://doi.org/10.4067/S0719-81322018000200101 |
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