The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
The placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may affect foetal nutrition, viability and lamb birth weight. Reproductive diseases...
| Autores principales: | , , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/14679 https://www.sciencedirect.com/science/article/pii/S0921448823001256 https://doi.org/10.1016/j.smallrumres.2023.107029 |
| _version_ | 1855037161027403776 |
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| author | Caspe, Sergio Gaston Palarea-Albaladejo, Javier Livingstone, Morag Wattegedera, Sean Ranjan Milne, Elspeth Sargison, Neil Donald Longbottom, David |
| author_browse | Caspe, Sergio Gaston Livingstone, Morag Longbottom, David Milne, Elspeth Palarea-Albaladejo, Javier Sargison, Neil Donald Wattegedera, Sean Ranjan |
| author_facet | Caspe, Sergio Gaston Palarea-Albaladejo, Javier Livingstone, Morag Wattegedera, Sean Ranjan Milne, Elspeth Sargison, Neil Donald Longbottom, David |
| author_sort | Caspe, Sergio Gaston |
| collection | INTA Digital |
| description | The placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may affect foetal nutrition, viability and lamb birth weight. Reproductive diseases, such as ovine enzootic abortion (OEA), impact on foetal viability due to the reduction in the functional area for maternofoetal exchange. This study aimed to consider the impact of pathological features of OEA placental lesions on lamb birth weight and indirectly on foetal viability. To investigate the relationship between birth weight and various OEA-related parameters, data from 562 lambs/foetuses from animals experimentally challenged with Chlamydia abortus strain S26/3 and from uninfected animals were analysed. The parameters investigated included the number of foetuses/lambs delivered (single/multiple), foetus/lamb sex, length of gestation, the proportion of placentas affected by lesions (percentage of gross placental pathology), foetal viability (live/aborted) and the number of C. abortus organisms shed in post-parturition vaginal excretions. The results suggest that the length of gestation and the proportion of placentas affected by lesions are the main contributors to birth weight variability, whereas the other factors, including foetal viability (live or aborted outcomes), were found to be less relevant co-variables. The study determined the strongest positive and negative correlations between birth weight were with the length of gestation and the extent of placental pathology, respectively. These results may indicate that economic losses associated with OEA infections result not only from aborted foetuses but also from the surviving lambs that are born weaker and consequently are more susceptible to diseases. |
| format | info:ar-repo/semantics/artículo |
| id | INTA14679 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA146792023-07-03T11:20:22Z The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus Caspe, Sergio Gaston Palarea-Albaladejo, Javier Livingstone, Morag Wattegedera, Sean Ranjan Milne, Elspeth Sargison, Neil Donald Longbottom, David Chlamydophila abortus Ewes Birth Weight Placenta Animal Diseases Abortion Oveja Peso al Nacimiento Enfermedades de los Animales Aborto Chlamydia abortus The placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may affect foetal nutrition, viability and lamb birth weight. Reproductive diseases, such as ovine enzootic abortion (OEA), impact on foetal viability due to the reduction in the functional area for maternofoetal exchange. This study aimed to consider the impact of pathological features of OEA placental lesions on lamb birth weight and indirectly on foetal viability. To investigate the relationship between birth weight and various OEA-related parameters, data from 562 lambs/foetuses from animals experimentally challenged with Chlamydia abortus strain S26/3 and from uninfected animals were analysed. The parameters investigated included the number of foetuses/lambs delivered (single/multiple), foetus/lamb sex, length of gestation, the proportion of placentas affected by lesions (percentage of gross placental pathology), foetal viability (live/aborted) and the number of C. abortus organisms shed in post-parturition vaginal excretions. The results suggest that the length of gestation and the proportion of placentas affected by lesions are the main contributors to birth weight variability, whereas the other factors, including foetal viability (live or aborted outcomes), were found to be less relevant co-variables. The study determined the strongest positive and negative correlations between birth weight were with the length of gestation and the extent of placental pathology, respectively. These results may indicate that economic losses associated with OEA infections result not only from aborted foetuses but also from the surviving lambs that are born weaker and consequently are more susceptible to diseases. EEA Mercedes Fil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unido Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina Fil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido Fil: Palarea-Albaladejo, Javier. University of Girona. Deparment of Computer Sciences, Applied Mathematics and Statistics; España Fil: Livingstone, Morag. Moredun Research Institute; Reino Unido Fil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unido Fil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido Fil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido Fil: Longbottom, David. Moredun Research Institute; Reino Unido 2023-07-03T10:39:41Z 2023-07-03T10:39:41Z 2023-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/20.500.12123/14679 https://www.sciencedirect.com/science/article/pii/S0921448823001256 0921-4488 1879-0941 https://doi.org/10.1016/j.smallrumres.2023.107029 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Small Ruminant Research : 107029 (Available online 28 June 2023) |
| spellingShingle | Chlamydophila abortus Ewes Birth Weight Placenta Animal Diseases Abortion Oveja Peso al Nacimiento Enfermedades de los Animales Aborto Chlamydia abortus Caspe, Sergio Gaston Palarea-Albaladejo, Javier Livingstone, Morag Wattegedera, Sean Ranjan Milne, Elspeth Sargison, Neil Donald Longbottom, David The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus |
| title | The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus |
| title_full | The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus |
| title_fullStr | The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus |
| title_full_unstemmed | The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus |
| title_short | The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus |
| title_sort | extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild type strain of chlamydia abortus |
| topic | Chlamydophila abortus Ewes Birth Weight Placenta Animal Diseases Abortion Oveja Peso al Nacimiento Enfermedades de los Animales Aborto Chlamydia abortus |
| url | http://hdl.handle.net/20.500.12123/14679 https://www.sciencedirect.com/science/article/pii/S0921448823001256 https://doi.org/10.1016/j.smallrumres.2023.107029 |
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